{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:14:18Z","timestamp":1787238858503,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI143439"],"award-info":[{"award-number":["R01 AI143439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Doxycycline postexposure prophylaxis (doxy-PEP) reduces the risk of bacterial sexually transmitted infections among men who have sex with men and transgender women. In the United States, doxy-PEP is in an early stage of integration into clinical practice, and national guidelines for its use were recently released. The goal of this manuscript is to provide practical guidance for clinicians who are considering or currently prescribing doxy-PEP. We address 5 clinical questions using post hoc analyses of data from the DoxyPEP randomized controlled trial and discuss the potential implications and limitations of each question with the goal of informing clinical practice and implementation of doxy-PEP programs. The questions address patient eligibility criteria for doxy-PEP, the expected benefit and associated doxy-PEP doses for the average patient, the initial number of doses prescribed, and laboratory monitoring of persons taking doxy-PEP.<\/jats:p>","DOI":"10.1093\/cid\/ciae527","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T16:21:50Z","timestamp":1730218910000},"page":"177-184","source":"Crossref","is-referenced-by-count":8,"title":["Evidence-Informed Provision of Doxycycline Postexposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-9428","authenticated-orcid":false,"given":"Julia C","family":"Dombrowski","sequence":"first","affiliation":[{"name":"Department of Medicine , University of Washington, Seattle, Washington, USA"},{"name":"Department of Epidemiology, University of Washington, Seattle, Washington ,","place":["USA"]},{"name":"HIV\/STI\/HCV Program, Public Health\u2013Seattle & King County , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Donnell","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutch Cancer Center , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-8654","authenticated-orcid":false,"given":"Cole","family":"Grabow","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-1074","authenticated-orcid":false,"given":"Stephanie E","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California ,","place":["USA"]},{"name":"Population Health Division, San Francisco Department of Public Health, San Francicso, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-754X","authenticated-orcid":false,"given":"Chase A","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Medicine , University of Washington, Seattle, Washington, USA"},{"name":"HIV\/STI\/HCV Program, Public Health\u2013Seattle & King County , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-1339","authenticated-orcid":false,"given":"Clare E","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-0712","authenticated-orcid":false,"given":"Susan P","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California ,","place":["USA"]},{"name":"Population Health Division, San Francisco Department of Public Health, San Francicso, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Celum","sequence":"additional","affiliation":[{"name":"Department of Medicine , University of Washington, Seattle, Washington, USA"},{"name":"Department of Epidemiology, University of Washington, Seattle, Washington ,","place":["USA"]},{"name":"Department of Global Health, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0911-1578","authenticated-orcid":false,"given":"Anne F","family":"Luetkemeyer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California 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