{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:13:38Z","timestamp":1790874818762,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24 AI 108516"],"award-info":[{"award-number":["K24 AI 108516"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK 109823"],"award-info":[{"award-number":["R01 DK 109823"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK125246"],"award-info":[{"award-number":["R01 DK125246"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K12 HL 143961"],"award-info":[{"award-number":["K12 HL 143961"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Integrase strand transfer inhibitors (INSTIs) and the menopausal transition have been associated with body composition changes in women with human immunodeficiency virus (WWH), but their interaction is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From 2006 to 2019, 1131 virally-suppressed WWH (419 who switched to INSTI [INSTI+]; 712 who did not switch [INSTI\u2013]) and 887 women without HIV (WWOH) from the Women's Interagency HIV Study were included. Mixed-effects models were used to evaluate change in waist circumference (WC) and body mass index (BMI) by menopausal phase defined using anti-M\u00fcllerian hormone, a biomarker of ovarian reserve.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During premenopause, WWH had increases in WC (INSTI+: 0.01\u2005cm per 6 months [95% confidence interval {CI}: \u2212.29 to .32] and INSTI\u2212: 0.22\u2005cm per 6 months [95% CI: \u2212.01 to .44]) that were not statistically significantly different from WWOH; there was also little difference by INSTI status. In late perimenopause, INSTI+ had faster increases in WC (0.37\u2005cm per 6 months [95% CI: .15\u2013.60]) while INSTI\u2212 had smaller increases (0.14\u2005cm per 6 months [95% CI: \u2212.06 to .34]) compared to WWOH. In menopause, INSTI+ had faster increases, peaking at 43 months then declining, while INSTI\u2212 had smaller increases (0.14\u2005cm per 6 months [95% CI: \u2212.02 to .30]). Compared to INSTI\u2212, in late perimenopause, INSTI+ had 0.26\u2005cm per 6 months (95% CI: .02\u2013.50) faster linear increases in WC and in menopause, INSTI+ was associated with faster increases, peaking at 41 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Switching to an INSTI-based regimen during late perimenopause and menopause is associated with faster increases in WC when compared to women who did not switch. Menopausal status should be considered when switching to an INSTI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciae540","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T18:04:11Z","timestamp":1730743451000},"page":"1125-1132","source":"Crossref","is-referenced-by-count":10,"title":["Switch to Integrase Strand Transfer Inhibitors During the Menopausal Transition Is Associated With Accelerated Body Composition Change in Women With HIV"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-1879","authenticated-orcid":false,"given":"Rebecca A","family":"Abelman","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, California ,","place":["USA"]},{"name":"Medical Service, San Francisco Veteran Affairs Health Care System , California, 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California, San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alcaide","sequence":"additional","affiliation":[{"name":"Department of Medicine, Miller School of Medicine, University of Miami , Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine , Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9515-2857","authenticated-orcid":false,"given":"Michelle","family":"Floris-Moore","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina School of Medicine , Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Topper","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M","family":"Weber","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine , Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seble G","family":"Kassaye","sequence":"additional","affiliation":[{"name":"Department of Medicine, Georgetown University Medical Center , Washington D.C., USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-8560","authenticated-orcid":false,"given":"Deborah","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Department of Neurology, State University 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