{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:03:39Z","timestamp":1781291019686,"version":"3.54.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The risk and severity of congenital toxoplasmosis were estimated using data from 2455 consecutive mother\u2013child pairs. Clinical signs at 3 years were halved in the 177 children born since 2009 compared with 1996\u20132008 (odds ratio = .49; 95% CI: .28\u2013.85). Materno-fetal transmission rates remained stable from 1992 to 2021.<\/jats:p>","DOI":"10.1093\/cid\/ciae634","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:01:58Z","timestamp":1734634918000},"page":"648-650","source":"Crossref","is-referenced-by-count":4,"title":["Congenital Toxoplasmosis: Fewer Clinical Signs at 3 Years of Age Over the Last 15 Years but Stable Risk of Materno-fetal Transmission"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8285-8550","authenticated-orcid":false,"given":"Martine","family":"Wallon","sequence":"first","affiliation":[{"name":"Service de Parasitologie et de Mycologie M\u00e9dicale, Institut des Agents Infectieux, Hospices Civils de Lyon , Lyon ,","place":["France"]},{"name":"Walking Team, Centre for Research in Neuroscience in Lyon , Bron ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-4899","authenticated-orcid":false,"given":"Elea","family":"Ksiazek","sequence":"additional","affiliation":[{"name":"CHU Dijon-Bourgogne, INSERM, Universit\u00e9 de Bourgogne, CIC1432, Module Epid\u00e9miologie Clinique , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1066-8191","authenticated-orcid":false,"given":"Antoine","family":"Journ\u00e9","sequence":"additional","affiliation":[{"name":"CHU Dijon-Bourgogne, INSERM, Universit\u00e9 de Bourgogne, CIC1432, Module Epid\u00e9miologie Clinique , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-1073","authenticated-orcid":false,"given":"Damien","family":"Dupont","sequence":"additional","affiliation":[{"name":"Service de Parasitologie et de Mycologie M\u00e9dicale, Institut des Agents Infectieux, Hospices Civils de Lyon , Lyon ,","place":["France"]},{"name":"Walking Team, Centre for Research in Neuroscience in Lyon , Bron ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5703-8403","authenticated-orcid":false,"given":"Jean","family":"Menotti","sequence":"additional","affiliation":[{"name":"Service de Parasitologie et de Mycologie M\u00e9dicale, Institut des Agents Infectieux, Hospices Civils de Lyon , Lyon ,","place":["France"]},{"name":"Universit\u00e9 Claude Bernard Lyon 1, Facult\u00e9 de M\u00e9decine Lyon-Sud Charles M\u00e9rieux, UR 3738\u2013CICLY\u2013Equipe Inflammation et Immunit\u00e9 de L\u2019\u00e9pith\u00e9lium Respiratoire , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Peyron","sequence":"additional","affiliation":[{"name":"Service de Parasitologie et de Mycologie M\u00e9dicale, Institut des Agents Infectieux, Hospices Civils de Lyon , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-5754","authenticated-orcid":false,"given":"Christine","family":"Binquet","sequence":"additional","affiliation":[{"name":"CHU Dijon-Bourgogne, INSERM, Universit\u00e9 de Bourgogne, CIC1432, Module Epid\u00e9miologie Clinique , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"2025100602575207700_ciae634-B1"},{"key":"2025100602575207700_ciae634-B2","doi-asserted-by":"crossref","first-page":"1900710","DOI":"10.2807\/1560-7917.ES.2021.26.5.1900710","article-title":"National perinatal survey demonstrates a decreasing seroprevalence of Toxoplasma gondii infection among pregnant women in France, 1995 to 2016: impact for screening policy","volume":"26","author":"Robinson","year":"2021","journal-title":"Euro Surveill"},{"key":"2025100602575207700_ciae634-B3","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3389\/fmicb.2018.02369","article-title":"Continuous decline of Toxoplasma gondii seroprevalence in hospital: a 1997\u20132014 longitudinal study in Paris, France","volume":"9","author":"Guigue","year":"2018","journal-title":"Front Microbiol"},{"key":"2025100602575207700_ciae634-B4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pt.2022.10.003","article-title":"Is the incidence of congenital toxoplasmosis declining?","volume":"39","author":"Milne","year":"2023","journal-title":"Trends Parasitol"},{"key":"2025100602575207700_ciae634-B5","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1017\/S0950268813002756","article-title":"Incidence and prevalence of Toxoplasma gondii infection in women in France, 1980\u20132020: model-based estimation","volume":"142","author":"Nogareda","year":"2014","journal-title":"Epidemiol Infect"},{"key":"2025100602575207700_ciae634-B6","author":"CNR Toxoplasmose"},{"key":"2025100602575207700_ciae634-B7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/cid\/cit032","article-title":"Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years","volume":"56","author":"Wallon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2025100602575207700_ciae634-B8","doi-asserted-by":"crossref","first-page":"386.e1","DOI":"10.1016\/j.ajog.2018.05.031","article-title":"Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial","volume":"219","author":"Mandelbrot","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2025100602575207700_ciae634-B9","first-page":"425","article-title":"Monotone regression splines in action","volume":"3","author":"Ramsay","year":"1988","journal-title":"Stat Sci"},{"key":"2025100602575207700_ciae634-B10","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00001648-199507000-00005","article-title":"Dose-response and trend analysis in epidemiology: alternatives to categorical analysis","volume":"6","author":"Greenland","year":"1995","journal-title":"Epidemiology"},{"key":"2025100602575207700_ciae634-B11","doi-asserted-by":"crossref","first-page":"E6956","DOI":"10.1073\/pnas.1722202115","article-title":"Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii","volume":"115","author":"Shwab","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025100602575207700_ciae634-B12","doi-asserted-by":"crossref","first-page":"e2023064114","DOI":"10.1542\/peds.2023-064114","article-title":"Long-term ocular outcomes in congenital toxoplasmosis treated perinatally","volume":"153","author":"Journ\u00e9","year":"2024","journal-title":"Pediatrics"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciae634\/61240009\/ciae634.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/81\/3\/648\/61240009\/ciae634.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/81\/3\/648\/61240009\/ciae634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:57:58Z","timestamp":1759733878000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/81\/3\/648\/7928948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,12,20]]},"published-print":{"date-parts":[[2025,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciae634","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9,15]]},"published":{"date-parts":[[2024,12,20]]}}}