{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:40:21Z","timestamp":1784299221700,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data regarding the effectiveness of vancomycin-resistant Enterococci (VRE)\u2013active prophylaxis for preventing early post\u2013liver transplantation (LT) VRE infections in VRE-colonized patients are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>131 pre-LT VRE-colonized patients who underwent LT were enrolled in a retrospective, observational, multicenter study. The incidence of early-onset VRE infections was compared between patients who received active prophylaxis for VRE and those who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-nine (52.7%) and 62 (47.3%) patients were enrolled in the VRE-active and non\u2013VRE-active prophylaxis group. Tigecycline was the most common drug prescribed as VRE-active for prophylaxis (55\/69; 79.7%). There was no significant difference in the number of patients who developed early-onset VRE infections in the VRE-active versus non\u2013VRE-active groups at 7 (0 [0.0%] vs 2 [3.2%]; P = .222), 14 (4 [5.7%] vs 4 [6.4%]; P = 1.000), and 30 (6 [8.7%] vs 8 [12.9%]; P = .621) days post-LT, respectively. Risk of early-onset VRE infection within 30 days was not lower in the VRE-active group (log-rank P = .16 with Kaplan-Meier analysis; odds ratio [OR]: .643; 95% CI: .210\u20131.969; P = .439 with univariate analysis). Conversely, early infections caused by any pathogen were significantly lower in the VRE-active prophylaxis group compared with the control group (11 [15.9%] vs 20 [32.2%]; P = .047). Tigecycline prophylaxis was associated with a lower risk of early-onset infections with multivariate analysis (OR: .106; 95% CI: .015\u2013.745; P = .024) and after adjusting for propensity score (adjusted OR: .146; 95% CI: .031\u2013.708; P = .017).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VRE-active prophylaxis at LT did not reduce the incidence of early post-LT VRE infections and should not be recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf121","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T16:24:40Z","timestamp":1741796680000},"page":"878-887","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Vancomycin-Resistant\n                    <i>Enterococci<\/i>\n                    (VRE)\u2013Active Perioperative Prophylaxis in Liver Transplant Patients Colonized by VRE"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1488-7680","authenticated-orcid":false,"given":"Giulia Jole","family":"Burastero","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedaliero-Universitaria of Modena , Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Q","family":"Wey","sequence":"additional","affiliation":[{"name":"Department of Infection, Royal Free London NHS Trust London , London ,","place":["United Kingdom"]},{"name":"Centre for Clinical Microbiology, Division of Infection and Immunity, UCL , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Guidetti","sequence":"additional","affiliation":[{"name":"FIM Department, University of Modena and Reggio Emilia , Modena 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