{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:05:59Z","timestamp":1782835559635,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030782","name":"Promex Stiftung fur die Forschung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030782","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["31CA30_196036"],"award-info":[{"award-number":["31CA30_196036"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33IC30_179636"],"award-info":[{"award-number":["33IC30_179636"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["314730_192616"],"award-info":[{"award-number":["314730_192616"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006387","name":"Leenaards Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Santos-Suarez Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While neutropenic enterocolitis (NEC) is a well-known life-threatening complication during intensive chemotherapy, its incidence, impact, and outcome on specific at-risk populations remain ill defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report 178 NEC episodes during 1963 myeloablative chemotherapy courses among 1259 adult patients with acute myeloid (AML) or lymphoblastic (ALL) leukemia or receiving autologous hematopoietic stem cell transplantation (auto-HCT) for lymphoma or multiple myeloma. Risk factors were assessed by multivariate logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most NEC cases (93.3%) occurred during AML induction (n = 92; 13.8% of chemotherapy course) and auto-HCT (n = 74; 9.5%). Independent risk factors for NEC during AML induction included high-dose corticosteroids (OR = 2.07; 95% CI: 1.29\u20133.30; P = .002), elevated circulating blasts at the time of diagnosis (&amp;gt;50\u2005Giga\/L; OR = 2.02; 95% CI: 1.15\u20133.56; P = .02), and use of azacitidine (OR = 2.45; 95% CI: 1.01\u20135.90; P = .05); purine-based regimens (eg, FLAG-Ida) were an independent protective factor (OR = .27; 95% CI: .15\u2013.47; P &amp;lt; .001). Independent risk factors after auto-HCT included BEAM (carmustine, etoposide, cytarabine, and melphalan) versus another conditioning protocol (OR = 3.28; 95% CI: 1.98\u20135.43; P &amp;lt; .001) and age (OR = 1.03\/year; 95% CI: 1.01\u20131.06; P = .007). For both AML induction and auto-HCT, NEC was associated with longer hospitalization (P = .03 and &amp;lt;.001), sepsis (quick SOFA \u22652; P = .03 and &amp;lt;.001), fungemia (P &amp;lt; .001 and P = .01), and intensive care admission (P = .03 and &amp;lt;.001, respectively). NEC was associated with increased in-hospital mortality during AML induction (6.5% vs 2.4%; P = .04) but not during auto-HCT (P = .3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of NEC depended on chemotherapeutic regimens, with higher occurrence during standard \u201c7 + 3\u201d AML induction and BEAM conditioning for auto-HCT. NEC was associated with longer hospitalization and increased morbidity, but 30-day mortality was lower than previously reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf134","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T16:47:03Z","timestamp":1742402823000},"page":"e296-e307","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-1977","authenticated-orcid":false,"given":"Anne-Sophie","family":"Brunel","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) , Lausanne ,","place":["Switzerland"]},{"name":"Infectious Diseases Service, University Hospital of Besan\u00e7on , Besan\u00e7on ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Seydoux","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siham","family":"Ahlyege","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Guillet","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7874-6337","authenticated-orcid":false,"given":"Katerina","family":"Mandralis","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-9201","authenticated-orcid":false,"given":"Mapi","family":"Fleury","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cairoli","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Blum","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-9421","authenticated-orcid":false,"given":"Olivier","family":"Spertini","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) , Lausanne ,","place":["Switzerland"]},{"name":"Department of Medicine, Ensemble Hospitalier de la C\u00f4te , Morges ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Gavillet","sequence":"additional","affiliation":[{"name":"Service and Central Laboratory of Hematology, Department of Oncology and Department of Laboratories and Pathology, Lausanne University Hospital (CHUV) and Lausanne University , Lausanne 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