{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:23:56Z","timestamp":1787682236177,"version":"build-2784847793"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022992","name":"MRC Clinical Trials Unit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00004\/03"],"award-info":[{"award-number":["MC_UU_00004\/03"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dolutegravir (DTG) is a preferred anchor antiretroviral therapy (ART) for children and adolescents with HIV (CAWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed the effectiveness and safety of DTG in CAWH aged 0\u201318 years at DTG start in routine care in Europe and Thailand, evaluating viral suppression (viral load [VL] &amp;lt;50 copies\/mL), cumulative incidence and associated factors of viral failure (VF; confirmed VL \u2265400 copies\/mL) and safety outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1230 CAWH on DTG, 49% were female. At DTG start, median (IQR) age was 14 (11\u201316) years, 10% were ART-naive, 49% ART-experienced\/suppressed (VL &amp;lt;200\u2005copies\/mL), 13% ART-experienced\/viremic (VL \u2265200\u2005copies\/mL), and 28% ART-experienced\/unknown VL. Median duration on DTG was 93 (49\u2013163) weeks. Virall suppression was 88%\u201391% throughout follow-up. Cumulative incidence (95% CI) of VF at weeks 96 and 144 was 4.3% (3.1%\u20136.1%) and 8.3% (6.2%\u201311.1%). Increased risk of VF was associated with female sex, ART-experienced\/viremic, advanced\/severe immunosuppression, previous treatment failure, and region (P &amp;lt; .05, adjusting for age, sex and ART\/VL status). The risk of VF was lower on DTG than CAWH on protease-inhibitor-based regimens (P &amp;lt; .001). Among 1146 with clinical data, 26 (2%) experienced 52 DTG-related adverse events, including 5 serious adverse events. Of 849 with laboratory data, 44 (5%) had 54 grade \u22653 events (&amp;lt;1 per 100 person-years). DTG discontinuation by weeks 96 and 144 was 5.0% (3.8%\u20136.7%) and 9.5% (7.5%\u201312.0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DTG was well tolerated, with \u223c90% virally suppressed &amp;lt;50\u2005copies\/mL. VF was low overall but was significantly higher in children\/adolescents ART-experienced and viraemic at DTG start, requiring close monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf191","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:34:22Z","timestamp":1744270462000},"page":"e115-e127","source":"Crossref","is-referenced-by-count":7,"title":["Viral Suppression, Viral Failure, and Safety Outcomes in Children and Adolescents With HIV on Dolutegravir in Europe and Thailand"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-8468","authenticated-orcid":false,"given":"Karen","family":"Scott","sequence":"first","affiliation":[{"name":"MRC Clinical Trials Unit at University College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"MRC Clinical 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