{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:28:28Z","timestamp":1791822508266,"version":"4.3.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI152772"],"award-info":[{"award-number":["R01AI152772"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32FP30_207285"],"award-info":[{"award-number":["32FP30_207285"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["324730_207957"],"award-info":[{"award-number":["324730_207957"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dolutegravir resistance is an increasing concern. An analysis of the DTG RESIST study found that among 227 integrase sequences from 7 African countries (all non-B subtypes), 59 (26.0%) had at least 1 major drug resistance mutation (primarily G118R and E138A\/K\/T), with 49 (21.6%) predicted to have high-level resistance to dolutegravir.<\/jats:p>","DOI":"10.1093\/cid\/ciaf204","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:43:19Z","timestamp":1744868599000},"page":"e128-e131","source":"Crossref","is-referenced-by-count":18,"title":["Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2049-3562","authenticated-orcid":false,"given":"Tom","family":"Loosli","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich , Zurich ,","place":["Switzerland"]},{"name":"Institute of Medical Virology, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-7746","authenticated-orcid":false,"given":"Carolyn","family":"Bolton Moore","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Research in Zambia , Lusaka ,","place":["Zambia"]},{"name":"Center for AIDS Research, School of Medicine, University of Alabama at Birmingham, Birmingham , Alabama ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Buzaalirwa","sequence":"additional","affiliation":[{"name":"AIDS Healthcare Foundation Uganda Cares , Masaka ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-1564","authenticated-orcid":false,"given":"Helen","family":"Byakwaga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-6463","authenticated-orcid":false,"given":"\u0130pek","family":"\u00c7elika\u011f","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-3523","authenticated-orcid":false,"given":"Cleophas","family":"Chimbetete","sequence":"additional","affiliation":[{"name":"Newlands Clinic , Harare ,","place":["Zimbabwe"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vanes","family":"Ebasone","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jamot, Yaound\u00e9 and Regional Hospital , Limb\u00e9 ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Giandhari","sequence":"additional","affiliation":[{"name":"KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal , Durban ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich , Zurich ,","place":["Switzerland"]},{"name":"Institute of Medical Virology, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-2487","authenticated-orcid":false,"given":"Jacqueline","family":"Huwa","sequence":"additional","affiliation":[{"name":"Lighthouse Trust , Lilongwe ,","place":["Malawi"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Kasozi","sequence":"additional","affiliation":[{"name":"Public Health Department, Regional Referral Hospital , Masaka ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolphe","family":"Mafoua","sequence":"additional","affiliation":[{"name":"Centre de Traitement Ambulatoire , Pointe Noire ,","place":["Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e8ne","family":"Messou","sequence":"additional","affiliation":[{"name":"Centre de Prise en Charge, de Recherche et de Formation , Abidjan ,","place":["C\u00f4te d\u2019Ivoire"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-6902","authenticated-orcid":false,"given":"Albert","family":"Minga","sequence":"additional","affiliation":[{"name":"Centre National de Transfusion Sanguine , Abidjan ,","place":["C\u00f4te d\u2019Ivoire"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Muula","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Research in Zambia , Lusaka ,","place":["Zambia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6694-2645","authenticated-orcid":false,"given":"Winnie","family":"Muyindike","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcel Christ Massamba","family":"Ndala","sequence":"additional","affiliation":[{"name":"Centre de Traitement Ambulatoire , Brazzaville ,","place":["Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamatha","family":"Sauermann","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-2239","authenticated-orcid":false,"given":"Aggrey","family":"Semeere","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Singh","sequence":"additional","affiliation":[{"name":"KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal , Durban ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-8348","authenticated-orcid":false,"given":"Roger D","family":"Kouyos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich , Zurich ,","place":["Switzerland"]},{"name":"Institute of Medical Virology, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-710X","authenticated-orcid":false,"given":"Richard","family":"Lessells","sequence":"additional","affiliation":[{"name":"KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal , Durban ,","place":["South Africa"]},{"name":"Centre for the AIDS Programme of Research in South Africa , Durban ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-5132","authenticated-orcid":false,"given":"Matthias","family":"Egger","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Bern , Bern ,","place":["Switzerland"]},{"name":"Centre for Infectious Disease Epidemiology and Research, Faculty of Health Sciences, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol , Bristol ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"2025110901590510800_ciaf204-B1","author":"World Health Organization"},{"key":"2025110901590510800_ciaf204-B2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/v16030399","article-title":"Prevalence of emergent dolutegravir resistance mutations in people living with HIV: a rapid scoping review","volume":"16","author":"Chu","year":"2024","journal-title":"Viruses"},{"key":"2025110901590510800_ciaf204-B3","doi-asserted-by":"crossref","first-page":"e733","DOI":"10.1016\/S2352-3018(23)00228-X","article-title":"HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis","volume":"10","author":"Loosli","year":"2023","journal-title":"Lancet HIV"},{"key":"2025110901590510800_ciaf204-B4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/infdis\/jiab382","article-title":"Monitoring emerging human immunodeficiency virus drug resistance in sub-Saharan Africa in the era of dolutegravir","volume":"225","author":"da Silva","year":"2022","journal-title":"J Infect Dis"},{"key":"2025110901590510800_ciaf204-B5","doi-asserted-by":"crossref","first-page":"ofac121","DOI":"10.1093\/ofid\/ofac121","article-title":"Detection of HIV virologic failure and switch to second-line therapy: a systematic review and meta-analysis of data from sub-Saharan Africa","volume":"9","author":"Bernab\u00e9","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2025110901590510800_ciaf204-B6","volume-title":"HIV drug resistance: brief report 2024","year":"2024"},{"key":"2025110901590510800_ciaf204-B7","doi-asserted-by":"crossref","first-page":"e085819","DOI":"10.1136\/bmjopen-2024-085819","article-title":"HIV-1 subtype-specific drug resistance on dolutegravir-based antiretroviral therapy: protocol for a multicentre study (DTG RESIST)","volume":"14","author":"Egger","year":"2024","journal-title":"BMJ Open"},{"key":"2025110901590510800_ciaf204-B8","doi-asserted-by":"crossref","first-page":"e035246","DOI":"10.1136\/bmjopen-2019-035246","article-title":"International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012\u20132019","volume":"10","author":"Chammartin","year":"2020","journal-title":"BMJ Open"},{"key":"2025110901590510800_ciaf204-B9","doi-asserted-by":"crossref","first-page":"e00136","DOI":"10.1128\/jcm.00136-24","article-title":"Performance of the Applied Biosystems HIV-1 genotyping kit with integrase","volume":"62","author":"Moore","year":"2024","journal-title":"J Clin Microbiol"},{"key":"2025110901590510800_ciaf204-B10","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1086\/503914","article-title":"Web resources for HIV type 1 genotypic-resistance test interpretation","volume":"42","author":"Liu","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2025110901590510800_ciaf204-B11","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1093\/nar\/gku739","article-title":"COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification","volume":"42","author":"Struck","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2025110901590510800_ciaf204-B12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.meegid.2013.04.032","article-title":"Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: performance evaluation of the new REGA version 3 and seven other tools","volume":"19","author":"Pineda-Pe\u00f1a","year":"2013","journal-title":"Infect Genet Evol"},{"key":"2025110901590510800_ciaf204-B13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/cid\/ciae261","article-title":"Virologic failure and drug resistance after programmatic switching to dolutegravir-based first-line antiretroviral therapy in Malawi and Zambia","volume":"80","author":"Skrivankova","year":"2025","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaf204\/63183634\/ciaf204.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/81\/4\/e128\/63183634\/ciaf204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/81\/4\/e128\/63183634\/ciaf204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:59:13Z","timestamp":1762671553000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/81\/4\/e128\/8131783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,5,20]]},"published-print":{"date-parts":[[2025,11,6]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaf204","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10,15]]},"published":{"date-parts":[[2025,5,20]]}}}