{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:38:25Z","timestamp":1791898705718,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite tuberculosis being a well-known concern in patients with advanced human immunodeficiency virus (HIV), the STATIS trial, which focused on its management, highlighted significant mortality rates. Histoplasmosis, a fungal disease endemic in sub-Saharan Africa, presents with similar clinical manifestations as tuberculosis. Therefore, it may be prevalent and potentially responsible for deaths in patients with advanced HIV in this region. We conducted an ancillary study of the ANRS STATIS trial to provide the first prevalence estimates of histoplasmosis among individuals with advanced HIV in C\u00f4te d'Ivoire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed urine samples from patients previously enrolled in the STATIS trial in C\u00f4te d\u2019Ivoire. These ambulatory patients with newly diagnosed HIV infection, CD4+ T-cell counts &amp;lt;100\/\u00b5L, and eligible for antiretroviral therapy (ART) were randomized to receive either systematic or test-guided tuberculosis treatment. We performed Histoplasma antigen enzyme immunoassay on their urine samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of Histoplasma antigenuria was 68\/280 (24.3%; 95% CI: 19.5%\u201329.8%), including 52\/280 (18.6%; 95% CI: 14.3%\u201323.7%) symptomatic patients. Of 22 tuberculosis cases documented at inclusion, 8 (36.4%) also had Histoplasma antigenuria. In patients who died within the 48-week follow-up, the prevalence of Histoplasma antigenuria was 15\/42 (35.7%% 95% CI: 22.0%\u201352.0%) compared with 22.3% (95% CI: 17.3%\u201328.2%) in those surviving. These survivors had a higher body mass index, CD4+ T-cell count, and hemoglobin and platelet count than those who died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of Histoplasma antigenuria was comparable to that of tuberculosis, and histoplasmosis was potentially responsible for preventable deaths. Prospective studies are needed to confirm these findings and promote screening strategies in sub-Saharan Africa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf237","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:47:08Z","timestamp":1747036028000},"page":"950-958","source":"Crossref","is-referenced-by-count":7,"title":["<i>Histoplasma<\/i>\n                    Antigenuria Prevalence in Patients With Advanced HIV Disease in C\u00f4te d\u2019Ivoire: A Prospective Trial Ancillary Study"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-9390","authenticated-orcid":false,"given":"Aude","family":"Sturny-Lecl\u00e8re","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group , Mycology Department, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-5145","authenticated-orcid":false,"given":"Ugo","family":"Fran\u00e7oise","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique Antilles Guyane INSERM CIC1424, Centre Hospitalier de Cayenne , Cayenne ,","place":["France"]},{"name":"Coordination R\u00e9gionale de Lutte Contre le VIH COREVIH Guyane, Centre Hospitalier de Cayenne , Cayenne ,","place":["France"]},{"name":"Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne , Cayenne ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-4266","authenticated-orcid":false,"given":"Anani D","family":"Badj\u00e9","sequence":"additional","affiliation":[{"name":"Programme ANRS Coop\u00e9ration C\u00f4te d\u2019Ivoire (PAC-CI)\/ANRS Research Site in C\u00f4te d'Ivoire , Abidjan , C\u00f4te d'Ivoire"},{"name":"INSERM U1219, University of Bordeaux, Institut de Recherche pour le D\u00e9veloppement (IRD) , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-2904","authenticated-orcid":false,"given":"Dea","family":"Garcia-Hermoso","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group , Mycology Department, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Aka","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Center on AIDS and Other Infectious Diseases (CeDReS) , Abidjan ,","place":["C\u00f4te 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,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-8060","authenticated-orcid":false,"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group , Mycology Department, Paris ,","place":["France"]},{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital Necker-Enfants Malades, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-3082","authenticated-orcid":false,"given":"Alexandre","family":"Alanio","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology Research Group , Mycology Department, Paris ,","place":["France"]},{"name":"Laboratoire de Parasitologie-Mycologie, H\u00f4pital Saint-Louis, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-4981","authenticated-orcid":false,"given":"Antoine A","family":"Adenis","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique Antilles Guyane INSERM CIC1424, Centre Hospitalier de Cayenne , Cayenne ,","place":["France"]},{"name":"Coordination R\u00e9gionale de Lutte Contre le VIH COREVIH Guyane, Centre Hospitalier de Cayenne , Cayenne ,","place":["France"]},{"name":"Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne , Cayenne 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