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These recommendations span treatment of asymptomatic Histoplasma pulmonary nodules (histoplasmomas), mild acute pulmonary histoplasmosis, and moderate acute pulmonary histoplasmosis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.<\/jats:p>","DOI":"10.1093\/cid\/ciaf256","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T10:54:27Z","timestamp":1752663267000},"page":"i27-i32","source":"Crossref","is-referenced-by-count":23,"title":["2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic\n                    <i>Histoplasma<\/i>\n                    Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People"],"prefix":"10.1093","volume":"81","author":[{"given":"Sandra R","family":"Arnold","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Le Bonheur Children's Hospital , Memphis, Tennessee ,","place":["USA"]},{"name":"University of Tennessee Health Science Center , Memphis, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7612-4710","authenticated-orcid":false,"given":"Andrej","family":"Spec","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Washington University in St Louis , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Baddley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland 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C","family":"Bahr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Kansas Medical Center , Kansas City, Kansas ,","place":["USA"]},{"name":"Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Bloch","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Duke University , Durham, North Carolina 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