{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:09:21Z","timestamp":1770700161165,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, a single hepatitis C virus (HCV) RNA at 2\u20136 months was sensitive and specific (86.7% and 95% confidence interval [CI], 62.1%\u201396.3% and 100% and 95% CI, 98.8%\u2013100%, respectively) in identifying perinatal transmission of HCV. No cases of perinatal infection requiring treatment were missed.<\/jats:p>","DOI":"10.1093\/cid\/ciaf266","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T07:49:06Z","timestamp":1750924146000},"page":"1102-1105","source":"Crossref","is-referenced-by-count":0,"title":["Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-656X","authenticated-orcid":false,"given":"Mona","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology of the Ohio State University , Columbus, Ohio ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-6712","authenticated-orcid":false,"given":"Grecio J","family":"Sandoval","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center , Washington, DC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-5302","authenticated-orcid":false,"given":"George R","family":"Saade","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenna L","family":"Hughes","sequence":"additional","affiliation":[{"name":"Brown University , Women and Infants Hospital of Rhode Island, Providence, Rhode Island ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca G","family":"Clifton","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center , Washington, DC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma M","family":"Reddy","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bartholomew","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology of the Ohio State University , Columbus, Ohio ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward K","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Case Western Reserve University , Cleveland, Ohio ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T N","family":"Tita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham , Birmingham, Alabama ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torri D","family":"Metz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah Health Sciences Center , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-1244","authenticated-orcid":false,"given":"Ronald J","family":"Wapner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gyneology, Columbia University , New York, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-4442","authenticated-orcid":false,"given":"Vishakha","family":"Sabharwal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyagriv N","family":"Simhan","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , Magee Womens Hospital, Pittsburgh, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-6993","authenticated-orcid":false,"given":"Geeta K","family":"Swamy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent D","family":"Heyborne","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine, Anschutz Medical Campus , Aurora, Colorado ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baha M","family":"Sibai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston\u2013Children's Memorial Hermann Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A","family":"Grobman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University , Chicago, Illinois ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser Y","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Stanford University , Stanford, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center , Dallas, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Parry","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A","family":"Macones","sequence":"additional","affiliation":[{"name":"Department of Womens Health, University of Texas at Austin , Austin, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"2026020907371240100_ciaf266-B1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/cld.978","article-title":"Hepatitis C virus elimination by 2030: conquering mount improbable","volume":"16","author":"Dhiman","year":"2021","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"2026020907371240100_ciaf266-B2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/AOG.0000000000005306","article-title":"Risk factors for perinatal transmission of hepatitis C virus","volume":"142","author":"Prasad","year":"2023","journal-title":"Obst Gynecol"},{"issue":"No. RR-2","key":"2026020907371240100_ciaf266-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6902a1","article-title":"CDC recommendations for hepatitis C screening among adults\u2014United States, 2020","volume":"69","author":"Schillie","year":"2020","journal-title":"MMWR Recomm Rep"},{"key":"2026020907371240100_ciaf266-B4","volume-title":"Red Book 2018 report of the Committee on Infections Diseases [hepatitis C]","author":"Kimberlin","year":"2018","edition":"31st ed"},{"key":"2026020907371240100_ciaf266-B5","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/MPG.0b013e318258328d","article-title":"North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. NASPGHAN practice guidelines: diagnosis and management of hepatitis C infection in infants, children, and adolescents","volume":"54","author":"Mack","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2026020907371240100_ciaf266-B6","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/cid\/ciw026","article-title":"Failure to test and identify perinatally infected children born to hepatitis C virus-infected women","volume":"62","author":"Kuncio","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2026020907371240100_ciaf266-B7","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.15585\/mmwr.mm6642a3","article-title":"Increased risk for mother-to-infant transmission of hepatitis C virus among Medicaid recipients\u2014 Wisconsin, 2011\u20132015","volume":"66","author":"Watts","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2026020907371240100_ciaf266-B8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jpeds.2012.05.002","article-title":"Expected and actual case ascertainment and treatment rates for children infected with hepatitis C in Florida and the United States: epidemiologic evidence from statewide and nationwide surveys","volume":"161","author":"Delgado-Borrego","year":"2012","journal-title":"J Pediatr"},{"key":"2026020907371240100_ciaf266-B9","doi-asserted-by":"crossref","first-page":"e20173273","DOI":"10.1542\/peds.2017-3273","article-title":"Hepatitis C virus screening among children exposed during pregnancy","volume":"141","author":"Chappell","year":"2018","journal-title":"Pediatrics"},{"key":"2026020907371240100_ciaf266-B10","doi-asserted-by":"crossref","first-page":"e20192482","DOI":"10.1542\/peds.2019-2482","article-title":"Hepatitis C testing among perinatally exposed infants","volume":"145","author":"Lopata","year":"2020","journal-title":"Pediatrics"},{"issue":"No. RR-4","key":"2026020907371240100_ciaf266-B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7204a1","article-title":"CDC recommendations for hepatitis C testing among perinatally exposed infants and children\u2014united States, 2023","volume":"72","author":"Panagiotakopoulos","year":"2023","journal-title":"MMWR Recom Rep"},{"key":"2026020907371240100_ciaf266-B12","doi-asserted-by":"crossref","first-page":"e20191275","DOI":"10.1542\/peds.2019-1275","article-title":"Well-child care adherence after intrauterine opioid exposure","volume":"145","author":"Goyal","year":"2020","journal-title":"Pediatrics"},{"key":"2026020907371240100_ciaf266-B13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/AOG.0000000000004760","article-title":"Medicaid Outcomes Distributed Research Network (MODRN). Postpartum follow-up care for pregnant persons with opioid use disorder and hepatitis C virus infection","volume":"139","author":"Jarlenski","year":"2022","journal-title":"Obstet Gynecol"},{"key":"2026020907371240100_ciaf266-B14","doi-asserted-by":"crossref","first-page":"e3340","DOI":"10.1093\/cid\/ciaa949","article-title":"Nucleic acid testing for diagnosis of perinatally acquired hepatitis C virus infection in early infancy","volume":"73","author":"Gowda","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2026020907371240100_ciaf266-B15","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1177\/0962280215592907","article-title":"Estimating negative likelihood ratio confidence when test sensitivity is 100%: a bootstrapping approach","volume":"26","author":"Marill","year":"2017","journal-title":"Stat Methods Med Res"},{"key":"2026020907371240100_ciaf266-B16","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1086\/497701","article-title":"Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy","volume":"192","author":"Mast","year":"2005","journal-title":"J Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaf266\/63738014\/ciaf266.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/81\/6\/1102\/63738014\/ciaf266.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/81\/6\/1102\/63738014\/ciaf266.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:37:22Z","timestamp":1770640642000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/81\/6\/1102\/8198398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,7,14]]},"published-print":{"date-parts":[[2026,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaf266","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12,15]]},"published":{"date-parts":[[2025,7,14]]}}}