{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:47:49Z","timestamp":1791650869342,"version":"4.3.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002738","name":"AP-HP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgound<\/jats:title>\n                    <jats:p>Invasive fungal diseases, among which includes invasive wound mucormycosis (IWM), are associated with poor outcomes in severely burned patients (SBPs). In recent years, quantitative real-time polymerase chain reaction (PCR) in serum to detect circulating Mucorales DNA (cmDNA) has shown promise for early diagnosis, reducing treatment duration and improving survival. Similarly, recent studies suggest that cmDNA detection enabled earlier diagnosis of IWM in SBPs. This retrospective study aimed to assess the impact of cmDNA-based diagnosis compared to conventional fungal culture on all-cause mortality at 30 and 100 days in SBPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed medical records of SBPs with proven or probable IWM over 2 periods, before and after the systematic implementation of cmDNA detection across 2 centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 37 IWM patients were included. No significant differences were observed in clinical characteristics, treatment regimens, or disease severity between both groups. Our findings indicate that systematic cmDNA detection allowed earlier diagnosis of IWM with a median of \u22128 days [\u221216; \u22124] than mycological culture. The 100-day mortality was reduced from 63.6% to 30.8% (P = .071), and significantly reduced when considering only patients with total body surface area (TBSA) \u2265 30% (P = .047), in the cmDNA group. This earlier detection was associated with early initiation of liposomal amphotericin B-based therapy combined with surgery and may have contributed to the improved outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>cmDNA screening in targeted high-risk SBPs allows for earlier initiation of specific treatment and appears to improve the prognosis of IWM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf423","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:30Z","timestamp":1753876290000},"page":"907-913","source":"Crossref","is-referenced-by-count":5,"title":["Weekly Screening of Circulating\n                    <i>Mucorales<\/i>\n                    DNA and Early Treatment in Severely Burned Patients Improves Survival: Real-Life Bi-center Experience in France"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-2706","authenticated-orcid":false,"given":"Emmanuel","family":"Faure","sequence":"first","affiliation":[{"name":"Service de Maladies Infectieuses, Centre Hospitalier Universitaire de Lille , Lille ,","place":["France"]},{"name":"CIIL\u2014Centre D\u2019Infection et D\u2019Immunit\u00e9 de Lille, U1019\u2014UMR 9017, Universit\u00e9 de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Cordier","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, Centre de Biologie Pathologie G\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Lille , Lille ,","place":["France"]},{"name":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, INSERM U1285, Universit\u00e9 de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Delacoste","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses, Centre Hospitalier Universitaire de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-5788","authenticated-orcid":false,"given":"Mathieu","family":"Jeanne","sequence":"additional","affiliation":[{"name":"CHU Lille, Anesthesia and Critical Care , Lille F-59000 ,","place":["France"]},{"name":"Universit\u00e9 de Lille , EA 7365 GRITA, Lille F-59000 ,","place":["France"]},{"name":"Inserm, CIC 1403 , Lille F-59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9988-4317","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"D\u00e9pret","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie et de Soins Intensifs et Unit\u00e9 des Br\u00fbl\u00e9s, H\u00f4pital Saint-Louis-Lariboisi\u00e8re, Universit\u00e9 Paris-Cit\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"UMR-S 942, Mascot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris 75010 ,","place":["France"]},{"name":"FHU PROMICE, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Hamane","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, H\u00f4pital Saint-Louis, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-7655","authenticated-orcid":false,"given":"Fanny","family":"Vuotto","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses, Centre Hospitalier Universitaire de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-9795","authenticated-orcid":false,"given":"Mahdi","family":"Ouafi","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, Centre de Biologie Pathologie G\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Cornu","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, Centre de Biologie Pathologie G\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Lille , Lille ,","place":["France"]},{"name":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, INSERM U1285, Universit\u00e9 de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-4889","authenticated-orcid":false,"given":"Emmanuel","family":"Dudoignon","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie et de Soins Intensifs et Unit\u00e9 des Br\u00fbl\u00e9s, H\u00f4pital Saint-Louis-Lariboisi\u00e8re, Universit\u00e9 Paris-Cit\u00e9, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"UMR-S 942, Mascot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris 75010 ,","place":["France"]},{"name":"FHU PROMICE, Assistance Publique-H\u00f4pitaux de Paris , Paris 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