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Neuroimaging revealed multifocal ring-enhancing lesions, raising the possibility of a broad differential diagnosis including leukemic infiltration and other CNS infections. Extensive evaluation including cultures and molecular assays were negative. Diagnosis was confirmed by a positive urine Histoplasma antigen and identification of fungus from brain tissue biopsy specimens. Targeted antifungal therapy led to complete clinical and radiological resolution, with sustained remission during 3 years of follow-up.<\/jats:p>","DOI":"10.1093\/cid\/ciaf441","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:52:53Z","timestamp":1755085973000},"page":"354-357","source":"Crossref","is-referenced-by-count":1,"title":["Intracranial Lesion in a Patient With Chronic Myeloid Leukemia"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1925-394X","authenticated-orcid":false,"given":"Mohammed Shakeel","family":"Sillat","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Christian Medical College , Vellore ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Chacko","sequence":"additional","affiliation":[{"name":"Department of Pathology, Christian Medical College , Vellore 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