{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:21:22Z","timestamp":1792736482343,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"Supplement_5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AI153546"],"award-info":[{"award-number":["K01AI153546"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54EB007958"],"award-info":[{"award-number":["U54EB007958"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The increasing rates of antimicrobial resistance (AMR) in Neisseria gonorrhoeae (NG) pose a challenge to the successful future treatment of gonorrhea. Although antimicrobial susceptibility testing (AST) is not routinely performed for NG, detection of antimicrobial susceptibility at the point-of-care (POC) could help guide treatment, including the re-use of previously-recommended treatment. We review the landscape of commercially-available tests and those under development for the rapid determination of AMR in NG. Additionally, we discuss the performance of new and novel nucleic acid-based phenotypic approaches for rapid characterization of AMR, which could potentially be implemented at the POC for resistance-guided therapy. Lastly, issues regarding the implementation of POC tests for resistance testing are discussed.<\/jats:p>","DOI":"10.1093\/cid\/ciaf517","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:15:48Z","timestamp":1758716148000},"page":"S243-S248","source":"Crossref","is-referenced-by-count":2,"title":["Current and Emerging Approaches and Technologies for Rapid Detection of\n                    <i>Neisseria gonorrhoeae<\/i>\n                    Antimicrobial Resistance"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-051X","authenticated-orcid":false,"given":"Johan H","family":"Melendez","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland \u00a0","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-5598","authenticated-orcid":false,"given":"Yukari C","family":"Manabe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland \u00a0","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026010808423997200_ciaf517-B1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41572-019-0128-6","article-title":"Gonorrhoea","volume":"5","author":"Unemo","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2026010808423997200_ciaf517-B2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3201\/eid3008.240139","article-title":"Surge in ceftriaxone-resistant Neisseria gonorrhoeae FC428-like strains, Asia-Pacific Region, 2015\u20132022","volume":"30","author":"Xiu","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"2026010808423997200_ciaf517-B3","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1093\/jac\/dkae369","article-title":"Ceftriaxone-resistant Neisseria gonorrhoeae detected in England, 2015\u201324: an observational analysis","volume":"79","author":"Fifer","year":"2024","journal-title":"J Antimicrob Chemother"},{"key":"2026010808423997200_ciaf517-B4","author":"World Health Organization"},{"key":"2026010808423997200_ciaf517-B5","volume-title":"Global action plan to control the spread of and impact of antimicrobial resistance in Neisseria gonorrhoeae","author":"WHO","year":"2012"},{"key":"2026010808423997200_ciaf517-B6","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1136\/sextrans-2016-053072","article-title":"Rapid accurate point-of-care tests combining diagnostics and antimicrobial resistance prediction for Neisseria gonorrhoeae and Mycoplasma genitalium","volume":"93","author":"Sadiq","year":"2017","journal-title":"Sex Transm Infect"},{"key":"2026010808423997200_ciaf517-B7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/14737159.2022.2015329","article-title":"Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects","volume":"22","author":"Golparian","year":"2022","journal-title":"Expert Rev Mol Diagn"},{"key":"2026010808423997200_ciaf517-B8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/OLQ.0000000000000591","article-title":"Wild-type gyrase a genotype of Neisseria gonorrhoeae predicts in vitro susceptibility to ciprofloxacin: a systematic review of the literature and meta-analysis","volume":"44","author":"Allan-Blitz","year":"2017","journal-title":"Sex Transm Dis"},{"key":"2026010808423997200_ciaf517-B9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1071\/SH18225","article-title":"Genotypic determinants of fluoroquinolone and macrolide 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