{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:51:46Z","timestamp":1789545106379,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GiveWell"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["093956\/Z\/10\/C"],"award-info":[{"award-number":["093956\/Z\/10\/C"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223253\/Z\/21\/Z"],"award-info":[{"award-number":["223253\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Infectious Diseases Research Collaboration"},{"name":"Malaria Consortium","award":["INV-043830"],"award-info":[{"award-number":["INV-043830"]}]},{"name":"Malaria Consortium","award":["INV-039889"],"award-info":[{"award-number":["INV-039889"]}]},{"DOI":"10.13039\/100021281","name":"Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Seasonal malaria chemoprevention (SMC) using monthly sulfadoxine-pyrimethamine-amodiaquine (SPAQ) is being deployed in East Africa, where antimalarial drug-resistance levels are high. Dihydroartemisinin-piperaquine (DP) is a potential alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective 28-day pharmacometric assessment of SMC was conducted in Karamoja, northern Uganda. In 2 villages children received SPAQ and in a third were randomized to DP versus no SMC. The primary outcome was malaria infection defined by capillary blood sample quantitative PCR (qPCR) positivity on day 28, or presentation with fever and slide or rapid test positivity after day 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline qPCR malaria parasitemia prevalence among 1250 enrolled children was 46% (575\/1250); Plasmodium falciparum 85%, other malarias (mainly Plasmodium ovale) 25%. Breakthrough parasitemias occurred in 7% (33\/496) of DP, 31% (158\/504) of SPAQ, and 39% (98\/250) of no drug recipients. Clinical malaria (all P falciparum) developed in 17% of no drug (42\/250; 1 severe), 8% of SPAQ (38\/504; 2 severe), and 2% of DP (13\/496) recipients. Adjusted protective efficacies against all malaria parasitemia, P falciparum parasitemia, and clinical malaria for SPAQ were 56% (95% CI, 35%\u201370%), 46% (11%\u201368%), and 60% (27%\u201378%) and for DP were 84% (77%\u201389%), 86% (75%\u201392%), and 86% (74%\u201392%), respectively. Some asymptomatic P falciparum infections were not cleared by SPAQ. All 260 P falciparum isolates genotyped were PfCRT K76 (haplotype CVMNK, marker of 4-aminoquinoline susceptibility); most were quintuple Pfdhfr\/dhps mutants (ie, relatively sulfadoxine-pyrimethamine resistant). The chemoprevention drug exposure\u2013response relationship was strong for desethylamodiaquine, but weak for sulfadoxine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SPAQ SMC had low clinical and parasitological chemopreventive efficacy in northern Uganda, whereas DP was effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trials Registration<\/jats:title>\n                    <jats:p>NCT05323721.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf615","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:02:39Z","timestamp":1762952559000},"source":"Crossref","is-referenced-by-count":4,"title":["Pharmacometric Evaluation of Sulfadoxine-Pyrimethamine-Amodiaquine and Dihydroartemisinin-Piperaquine Seasonal Malaria Chemoprevention in Northern Uganda"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-9384","authenticated-orcid":false,"given":"Craig","family":"Bonnington","sequence":"first","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Nuwa","sequence":"additional","affiliation":[{"name":"Malaria Consortium , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-7847","authenticated-orcid":false,"given":"Katherine","family":"Theiss-Nyland","sequence":"additional","affiliation":[{"name":"Malaria Consortium , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-9182","authenticated-orcid":false,"given":"Richard","family":"Kajubi","sequence":"additional","affiliation":[{"name":"Malaria Consortium , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R","family":"Kamya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-3845","authenticated-orcid":false,"given":"Joaniter","family":"Nankabirwa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ebong","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Nabakooza","sequence":"additional","affiliation":[{"name":"Ministry of Health , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Opigo","sequence":"additional","affiliation":[{"name":"Ministry of Health , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Salandindi","sequence":"additional","affiliation":[{"name":"Malaria Consortium , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Odongo","sequence":"additional","affiliation":[{"name":"Malaria Consortium , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-6024","authenticated-orcid":false,"given":"Chayanin","family":"Sararat","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-0325","authenticated-orcid":false,"given":"James A","family":"Watson","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , Oxford ,","place":["United Kingdom"]},{"name":"Infectious Diseases Data Observatory, Nuffield Department of Medicine, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokon","family":"Suwannasin","sequence":"additional","affiliation":[{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-5473","authenticated-orcid":false,"given":"Stephane","family":"Proux","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University , Mae Sot ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urairat","family":"Koesukwiwat","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-4030","authenticated-orcid":false,"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , Oxford ,","place":["United Kingdom"]},{"name":"Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Imwong","sequence":"additional","affiliation":[{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-4597","authenticated-orcid":false,"given":"James","family":"Tibenderana","sequence":"additional","affiliation":[{"name":"Malaria Consortium , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois H","family":"Nosten","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , Oxford ,","place":["United Kingdom"]},{"name":"Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University , Mae Sot ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1978","authenticated-orcid":false,"given":"Nicholas J","family":"White","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , Oxford ,","place":["United Kingdom"]},{"name":"Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2025120801063844300_ciaf615-B1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(20)32227-3","article-title":"Effectiveness of seasonal malaria chemoprevention at scale in West and Central Africa: an observational study","volume":"396","author":"ACCESS-SMC Partnership","year":"2020","journal-title":"Lancet"},{"key":"2025120801063844300_ciaf615-B2","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1016\/S2214-109X(20)30475-7","article-title":"Seasonal malaria chemoprevention in the Sahel subregion of Africa: a cost-effectiveness and cost-savings analysis","volume":"9","author":"Gilmartin","year":"2021","journal-title":"Lancet Glob Health"},{"key":"2025120801063844300_ciaf615-B3","doi-asserted-by":"crossref","first-page":"e1003727","DOI":"10.1371\/journal.pmed.1003727","article-title":"Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: case-control studies in 5 countries","volume":"18","author":"Cairns","year":"2021","journal-title":"PLoS Med"},{"key":"2025120801063844300_ciaf615-B4","author":"World Health Organization"},{"key":"2025120801063844300_ciaf615-B5","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ncomms1879","article-title":"Estimating the potential public health impact of seasonal malaria chemoprevention in African children","volume":"3","author":"Cairns","year":"2012","journal-title":"Nat Commun"},{"key":"2025120801063844300_ciaf615-B6","doi-asserted-by":"crossref","first-page":"e1000409","DOI":"10.1371\/journal.pmed.1000409","article-title":"Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in The Gambia: a randomised controlled trial","volume":"8","author":"Bojang","year":"2011","journal-title":"PLoS Med"},{"key":"2025120801063844300_ciaf615-B7","author":"World Health Organization","year":"2012"},{"key":"2025120801063844300_ciaf615-B8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s12936-022-04434-w","article-title":"Effectiveness of seasonal malaria chemoprevention in three regions of Togo: a population-based longitudinal study from 2013 to 2020","volume":"21","author":"Bakai","year":"2022","journal-title":"Malar J"},{"key":"2025120801063844300_ciaf615-B9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12936-022-04115-8","article-title":"Malaria chemoprevention and drug resistance: a review of the literature and policy implications","volume":"21","author":"Plowe","year":"2022","journal-title":"Malar J"},{"key":"2025120801063844300_ciaf615-B10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1473-3099(22)00593-X","article-title":"Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine-pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study","volume":"23","author":"Beshir","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"2025120801063844300_ciaf615-B11","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1371\/journal.pmed.0020003","article-title":"Intermittent presumptive treatment for malaria","volume":"2","author":"White","year":"2005","journal-title":"PLoS Med"},{"key":"2025120801063844300_ciaf615-B12","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/trstmh\/trad042","article-title":"A proposed method of grading malaria chemoprevention efficacy","volume":"117","author":"White","year":"2023","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2025120801063844300_ciaf615-B13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1056\/NEJMoa2211803","article-title":"Evolution of partial resistance to artemisinins in malaria parasites in Uganda","volume":"389","author":"Conrad","year":"2023","journal-title":"N Engl J Med"},{"key":"2025120801063844300_ciaf615-B14","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1186\/s12936-023-04488-4","article-title":"A non-randomized controlled trial to assess the protective effect of SMC in the context of high parasite resistance in Uganda","volume":"22","author":"Nuwa","year":"2023","journal-title":"Malar J"},{"key":"2025120801063844300_ciaf615-B15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1473-3099(24)00746-1","article-title":"Effectiveness of sulfadoxine-pyrimethamine plus amodiaquine and dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in Uganda: a three-arm, open-label, non-inferiority and superiority, cluster-randomised controlled trial","volume":"25","author":"Nuwa","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"2025120801063844300_ciaf615-B16","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1186\/1475-2875-8-200","article-title":"Population pharmacokinetics of artesunate and amodiaquine in African children","volume":"8","author":"Stepniewska","year":"2009","journal-title":"Malar J"},{"key":"2025120801063844300_ciaf615-B17","doi-asserted-by":"crossref","first-page":"e1002212","DOI":"10.1371\/journal.pmed.1002212","article-title":"Population pharmacokinetic properties of piperaquine in falciparum malaria: an individual participant data meta-analysis","volume":"14","author":"Hoglund","year":"2017","journal-title":"PLoS Med"},{"key":"2025120801063844300_ciaf615-B18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jmsacl.2023.12.004","article-title":"A high-throughput LC-MS\/MS assay for piperaquine from dried blood spots: improving malaria treatment in resource-limited settings","volume":"31","author":"Blessborn","year":"2023","journal-title":"J Mass Spectrom Adv Clin Lab"},{"key":"2025120801063844300_ciaf615-B19","doi-asserted-by":"crossref","first-page":"122887","DOI":"10.1016\/j.jchromb.2021.122887","article-title":"High-throughput quantitation method for amodiaquine and desethylamodiaquine in plasma using supported liquid extraction technology","volume":"1179","author":"Kaewkhao","year":"2021","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2025120801063844300_ciaf615-B20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev-micro-020518-115546","article-title":"Molecular mechanisms of drug resistance in Plasmodium falciparum malaria","volume":"74","author":"Wicht","year":"2020","journal-title":"Annu Rev Microbiol"},{"key":"2025120801063844300_ciaf615-B21","doi-asserted-by":"crossref","first-page":"e0010924","DOI":"10.1128\/cmr.00109-24","article-title":"Artemisinin-resistant malaria","volume":"37","author":"White","year":"2024","journal-title":"Clin Microbiol Rev"},{"key":"2025120801063844300_ciaf615-B22","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/cpt.1707","article-title":"Adherence and population pharmacokinetic properties of amodiaquine when used for seasonal malaria chemoprevention in African children","volume":"107","author":"Ding","year":"2020","journal-title":"Clin Pharmacol Ther"},{"key":"2025120801063844300_ciaf615-B23","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1186\/s12936-020-03553-6","article-title":"Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria","volume":"20","author":"Anyorigiya","year":"2021","journal-title":"Malar J"},{"key":"2025120801063844300_ciaf615-B24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0140-6736(86)92371-8","article-title":"Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria","volume":"1","author":"Hatton","year":"1986","journal-title":"Lancet"},{"key":"2025120801063844300_ciaf615-B25","author":"Infectious Diseases Data Observatory: Worldwide Antimalarial Resistance Network"},{"key":"2025120801063844300_ciaf615-B26","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S1097-2765(05)00077-8","article-title":"Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance","volume":"6","author":"Fidock","year":"2000","journal-title":"Mol Cell"},{"key":"2025120801063844300_ciaf615-B27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1074045","article-title":"Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by Pfcrt mutations","volume":"298","author":"Sidhu","year":"2002","journal-title":"Science"},{"key":"2025120801063844300_ciaf615-B28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jiph.2022.03.015","article-title":"Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: a systematic review","volume":"15","author":"Njiro","year":"2022","journal-title":"J Infect Public Health"},{"key":"2025120801063844300_ciaf615-B29","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1128\/AAC.05877-11","article-title":"Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria","volume":"56","author":"Lwin","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2025120801063844300_ciaf615-B30","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/jac\/dkac081","article-title":"Effect of dihydroartemisinin\/piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV","volume":"77","author":"Banda","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"2025120801063844300_ciaf615-B31","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S0140-6736(22)02535-1","article-title":"Effect of monthly intermittent preventive treatment with dihydroartemisinin-piperaquine with and without azithromycin versus monthly sulfadoxine-pyrimethamine on adverse pregnancy outcomes in Africa: a double-blind randomised, partly placebo-controlled trial","volume":"401","author":"Madanitsa","year":"2023","journal-title":"Lancet"},{"key":"2025120801063844300_ciaf615-B32","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/cid\/ciu150","article-title":"Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: randomized, placebo-controlled trial","volume":"58","author":"Nankabirwa","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2025120801063844300_ciaf615-B33","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1056\/NEJMoa2002820","article-title":"Malaria chemoprevention in the post-discharge management of severe anemia","volume":"383","author":"Kwambai","year":"2020","journal-title":"N Engl J Med"},{"key":"2025120801063844300_ciaf615-B34","author":"World Health Organization Global Malaria Program"},{"key":"2025120801063844300_ciaf615-B35","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1473-3099(24)00766-7","article-title":"Expanding seasonal malaria chemoprevention beyond the Sahel region","volume":"25","author":"ter Kuile","year":"2025","journal-title":"Lancet Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaf615\/65285708\/ciaf615.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaf615\/65285708\/ciaf615.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:06:49Z","timestamp":1765174009000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciaf615\/8322549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaf615","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"article-number":"ciaf615"}}