{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:06:34Z","timestamp":1779321994285,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"CIBER\u2014Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red","award":["CB21\/13\/00091"],"award-info":[{"award-number":["CB21\/13\/00091"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n and Uni\u00f3n Europea\u2014NextGenerationEU"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With antiretroviral therapy (ART), people with HIV (PWH) live longer and face age-related health challenges. The long-term evolution of non-AIDS comorbidities in this population remains unclear. We assessed temporal trends in incidence and age at onset of major age-related outcomes in PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a longitudinal study using CoRIS, a nationwide cohort of ART-naive PWH in Spain. Participants were grouped into 3 calendar periods (2006\u20132011, 2012\u20132017, and 2018\u20132023). The primary outcome was serious non-AIDS events (SNAEs), including major cardiovascular events, non-AIDS malignancies, and non-AIDS deaths. Secondary outcomes were hypertension, diabetes, dyslipidemia, heart failure, fracture, chronic kidney disease, dementia, and polypharmacy. Incidence was analyzed with Kaplan\u2013Meier and Cox models, age at onset with adjusted linear regression. Analyses were stratified by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 18 659 participants (55 133 person-years), 85% were male, median age 35 years. SNAE incidence declined (adjusted HR for 2018\u20132023 vs 2006\u20132011: 0.68, 95%CI .50\u2013.92), with delayed predicted age at first event (42.2 to 48.6 years, P &amp;lt; .001). Secondary comorbidity incidence was largely stable, while polypharmacy rose, especially in older adults and women. Women showed smaller reductions in SNAE incidence (from 9.3 to 6.5 per 1000 person-years vs 13.0 to 6.4 per 1000 person-years in men) and higher rates of hypertension and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Spain, serious age-related outcomes among PWH have declined with delayed onset, consistent with improvements in HIV management and prevention of comorbidities. However, persistent comorbidity burden and rising polypharmacy\u2014particularly among women\u2014highlight the need for targeted strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf622","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:01:48Z","timestamp":1762952508000},"page":"776-784","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Age-Related Health Outcomes in People with HIV in Spain, 2006\u20132023"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-3908","authenticated-orcid":false,"given":"Javier","family":"Mart\u00ednez-Sanz","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS , Madrid ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4896-6528","authenticated-orcid":false,"given":"Alejandro","family":"G. Garc\u00eda-Ruiz de Morales","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS , Madrid ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Medicine and Medical Specialties, University of Alcal\u00e1, Alcal\u00e1 de Henares , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-790X","authenticated-orcid":false,"given":"Juan","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Departamento de Medicina, Unidad de Enfermedades Infecciosas y Microbiolog\u00eda, Hospital Universitario Virgen de Valme, IBiS, Universidad de Sevilla , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8643-4250","authenticated-orcid":false,"given":"Antonio","family":"Rivero","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Infectious Diseases, Hospital Universitario Reina Sof\u00eda, Clinical Virology and Zoonoses Research Group, Universidad de C\u00f3rdoba, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) , C\u00f3rdoba ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Blanco Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic de Barcelona, IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xabier","family":"Camino Ortiz de Barr\u00f3n","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Hospital Universitario Donostia\/Donostia Unibertsitate Ospitalea , Gipuzkoa ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Calzado Isbert","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Parc Tauli Hospital Universitari, Institut d'Investigaci\u00f3 i Innovaci\u00f3 Parc Tauli (I3PT-CERCA) , Sabadell ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Novella Mena","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"S\u00e1nchez-Conde","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS , Madrid ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-1094","authenticated-orcid":false,"given":"Santiago","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS , Madrid ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Medicine and Medical Specialties, University of Alcal\u00e1, Alcal\u00e1 de Henares , Madrid 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