{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:58:12Z","timestamp":1773709092420,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI120938"],"award-info":[{"award-number":["R01AI120938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK131926"],"award-info":[{"award-number":["R01DK131926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI138897"],"award-info":[{"award-number":["U01AI138897"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI134591"],"award-info":[{"award-number":["U01AI134591"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI177211"],"award-info":[{"award-number":["U01AI177211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AI157893"],"award-info":[{"award-number":["K23AI157893"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney transplantation (KT) from donors with human immunodeficiency virus (HIV-1) to recipients with HIV (HIV D+\/R+) is noninferior to KT from donors without HIV (HIV D\u2212\/R+) with regard to safety. However, there may be differences in posttransplant infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a secondary analysis of the HOPE in Action KT Study (NCT02602262) comparing the time to first clinically relevant infection within 24 months posttransplantation in 99 HIV D+\/R+ versus 99 HIV D\u2212\/R+. Secondary outcomes included incidence rates, infection-related death, and timing of clinically relevant infection, each stratified by donor HIV status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cumulative incidence of a clinically relevant infection at 24 months posttransplantation was 73.8% (95% confidence interval [CI]: 63.1%\u201381.2%) for HIV D+\/R+ versus 64.7% (95% CI: 53.0%\u201373.4%) for HIV D\u2212\/R+. Comparing time to first clinically relevant infection in HIV D+\/R+ versus HIV D\u2212\/R+, the adjusted hazard ratio (aHR) was 1.44 (95% CI: 1.01\u20132.04) at 24 months posttransplantation; for infections associated with hospitalization, the aHR was not significantly higher (1.21 [95% CI: .78\u20131.86). There were no significant differences in the number of infections, death from infection, duration, or site of infection between HIV D+\/R+ versus HIV D\u2212\/R+, though viral infections were numerically more common in HIV D+\/R+ (40% vs 35%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although there was a statistically significant association between receipt of a kidney from a donor with HIV and time to first clinically relevant infection in the 24 months posttransplantation, there were no differences in infections associated with hospitalization. These data are overall reassuring as this emerging practice expands into clinical care.<\/jats:p>\n                    <jats:p>Clinical Trials Registration. NCT02602262.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf656","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:47:13Z","timestamp":1764679633000},"page":"e549-e557","source":"Crossref","is-referenced-by-count":0,"title":["Infections After Kidney Transplantation From Donors With HIV to Recipients With HIV"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4378-279X","authenticated-orcid":false,"given":"Elizabeth C","family":"Arant","sequence":"first","affiliation":[{"name":"Department of Medicine, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-9268","authenticated-orcid":false,"given":"Thibaut","family":"Davy-Mendez","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-5546","authenticated-orcid":false,"given":"Tao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moreno","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-3059","authenticated-orcid":false,"given":"Cynthia L","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi M","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai , New York, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Friedman-Moraco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Emory University , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-1880","authenticated-orcid":false,"given":"Alexander","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Medicine, Georgetown University , Washington District of Columbia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Stock","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California , San Francisco, San Francisco, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-905X","authenticated-orcid":false,"given":"Sapna A","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine, NYU Langone Transplant Institute , New York, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikha","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-5460","authenticated-orcid":false,"given":"Valentina","family":"Stosor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois 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Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-9338","authenticated-orcid":false,"given":"David","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Southwestern Medical Center , Dallas, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-6170","authenticated-orcid":false,"given":"Emily A","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Ranganna","sequence":"additional","affiliation":[{"name":"Department of Medicine, Drexel University College of Medicine , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwafisayo","family":"Adebiyi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University Health , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-7347","authenticated-orcid":false,"given":"Nahel","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A","family":"Castillo-Lugo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Methodist Health System Clinical Research Institute , Dallas, Texas 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,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"van Delden","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Unit, Service of Infectious Diseases, University Hospital Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-0943","authenticated-orcid":false,"given":"Oriol","family":"Manuel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lausanne University Hospital , Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-3191","authenticated-orcid":false,"given":"Nicolas J","family":"Mueller","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich , Zurich 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