{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:29:21Z","timestamp":1787840961905,"version":"build-2784847793"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["OE20-2001"],"award-info":[{"award-number":["OE20-2001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Enhancing Public Health Capabilities and Increasing Capacity National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Point-of-care tests (POCTs) for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae offer the potential for rapid diagnosis and treatment, improving patient outcomes and reducing disease transmission. We sought to compile evidence on the accuracy and clinical utility of molecular-based POCTs and near-POCTs for the detection of C. trachomatis and N. gonorrhoeae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic literature search of 5 electronic databases from January 2009 to January 2024 to understand the performance characteristics and implementation considerations associated with Food and Drug Administration\u2013cleared POCTs and near-POCTs. Results were described in a narrative format.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 3743 identified studies, 64 met our inclusion criteria. As of 2025, there are 4 Food and Drug Administration\u2013cleared POCTs\/near-POCTs for detecting C. trachomatis and N. gonorrhoeae, 3 of which are waived by the Clinical Laboratory Improvement Amendments and suitable for use during a patient visit. Evidence suggests that POCTs are most beneficial in symptomatic patients within acute care settings, where they can prevent loss to follow-up and reduce the need for empiric antibiotic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While some POCTs for C. trachomatis and N. gonorrhoeae have achieved regulatory clearance, challenges remain, including the need to expand specimen type clearance to include extragenital specimens, to further improve turnaround times, and to decrease cost for adoption. There is need to optimize the use of POCTs in acute care settings to manage sexually transmitted infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf699","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:56:00Z","timestamp":1766235360000},"page":"S43-S51","source":"Crossref","is-referenced-by-count":2,"title":["Point-of-care Tests for\n                    <i>Chlamydia trachomatis<\/i>\n                    and\n                    <i>Neisseria gonorrhoeae<\/i>\n                    : Review of the Literature"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-5598","authenticated-orcid":false,"given":"Yukari C","family":"Manabe","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-872X","authenticated-orcid":false,"given":"Amanda C","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Trow","sequence":"additional","affiliation":[{"name":"Association of Public Health Laboratories , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-8819","authenticated-orcid":false,"given":"Anthony","family":"Tran","sequence":"additional","affiliation":[{"name":"California Department of Public Health, Center for Laboratory Sciences , Richmond, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-8564","authenticated-orcid":false,"given":"Barbara","family":"Van Der Pol","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham Heersink School of Medicine , Birmingham, Alabama ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"2026041604061029100_ciaf699-B1","author":"Centers for Disease Control and Prevention"},{"key":"2026041604061029100_ciaf699-B2","author":"European Centre for Disease Prevention and Control"},{"key":"2026041604061029100_ciaf699-B3","doi-asserted-by":"crossref","first-page":"e235058-e","DOI":"10.1001\/jamahealthforum.2023.5058","article-title":"Changes in health care access and preventive health screenings by race and ethnicity","volume":"5","author":"Alba","year":"2024","journal-title":"JAMA Health Forum"},{"key":"2026041604061029100_ciaf699-B4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2021.14081","article-title":"Screening for chlamydia and gonorrhea: US preventive services task force recommendation statement","volume":"326","author":"Davidson","year":"2021","journal-title":"JAMA"},{"key":"2026041604061029100_ciaf699-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"2026041604061029100_ciaf699-B6","doi-asserted-by":"crossref","first-page":"e015349","DOI":"10.1136\/bmjgh-2024-015349","article-title":"At-home specimen self-collection as an additional testing strategy for chlamydia and gonorrhoea: a systematic literature review and meta-analysis","volume":"9","author":"Smith","year":"2024","journal-title":"BMJ Glob Health"},{"issue":"RR-15","key":"2026041604061029100_ciaf699-B7","first-page":"1","article-title":"Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections\u20132002","volume":"51","author":"Johnson","year":"2002","journal-title":"MMWR Recomm Rep"},{"key":"2026041604061029100_ciaf699-B8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1370\/afm.2942","article-title":"Vaginal swab vs urine for detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis: a meta-analysis","volume":"21","author":"Aaron","year":"2023","journal-title":"Ann Fam Med"},{"key":"2026041604061029100_ciaf699-B9","doi-asserted-by":"crossref","first-page":"e0132776","DOI":"10.1371\/journal.pone.0132776","article-title":"Self-collected versus clinician-collected sampling for chlamydia and gonorrhea screening: a systemic review and meta-analysis","volume":"10","author":"Lunny","year":"2015","journal-title":"PLoS One"},{"issue":"RR-02","key":"2026041604061029100_ciaf699-B10","first-page":"1","article-title":"Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae\u20132014","volume":"63","author":"Centers for Disease Control and Prevention","year":"2014","journal-title":"MMWR Recomm Rep"},{"key":"2026041604061029100_ciaf699-B11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clinbiochem.2021.11.003","article-title":"The impact of COVID-19 pandemic on technologic and process innovation in point-of-care diagnostics for sexually transmitted infections","volume":"117","author":"Manabe","year":"2021","journal-title":"Clin Biochem"},{"key":"2026041604061029100_ciaf699-B12","doi-asserted-by":"crossref","first-page":"2892734","DOI":"10.1155\/2020\/2892734","article-title":"Evaluation of the diagnostic efficacy of Xpert CT\/NG for Chlamydia trachomatis and Neisseria gonorrhoeae","volume":"2020","author":"Xie","year":"2020","journal-title":"Biomed Res Int"},{"key":"2026041604061029100_ciaf699-B13","first-page":"1021","article-title":"Validation of the GeneXpert\u00ae CT\/NG assay for use with male pharyngeal and rectal swabs","volume":"3","author":"Geiger","year":"2016","journal-title":"Austin J HIV AIDS Res"},{"key":"2026041604061029100_ciaf699-B14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12879-024-09042-4","article-title":"Clinic-based evaluation of the dual Xpert CT\/NG assay on the GeneXpert system for screening for extragenital chlamydial and gonococcal infections amongst men who have sex with men","volume":"24","author":"Cordioli","year":"2024","journal-title":"BMC Infect Dis"},{"key":"2026041604061029100_ciaf699-B15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/OLQ.0000000000001115","article-title":"Performance of 4 molecular assays for detection of chlamydia and gonorrhea in a sample of human immunodeficiency virus-positive men who have sex with men","volume":"47","author":"Footman","year":"2020","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1071\/SH19028","article-title":"Reduced sensitivity from pooled urine, pharyngeal and rectal specimens when using a molecular assay for the detection of chlamydia and gonorrhoea near the point of care","volume":"17","author":"Badman","year":"2020","journal-title":"Sex Health"},{"key":"2026041604061029100_ciaf699-B17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1586\/14737159.2014.871495","article-title":"Review of use of a new rapid real-time PCR, the cepheid GeneXpert\u00ae (Xpert) CT\/NG assay, for Chlamydia trachomatis and Neisseria gonorrhoeae: results for patients while in a clinical setting","volume":"14","author":"Gaydos","year":"2014","journal-title":"Expert Rev Mol Diagn"},{"key":"2026041604061029100_ciaf699-B18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/OLQ.0000000000000627","article-title":"Comparative evaluation of 2 nucleic acid amplification tests for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae at extragenital sites","volume":"44","author":"Bristow","year":"2017","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.diagmicrobio.2017.10.013","article-title":"Comparison of the cepheid GeneXpert CT\/NG assay to the Hologic Aptima Combo2 assay for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in self-collected rectal swabs","volume":"90","author":"Dize","year":"2018","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2026041604061029100_ciaf699-B20","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1128\/JCM.03461-12","article-title":"Performance of the cepheid CT\/NG Xpert rapid PCR test for detection of Chlamydia trachomatis and Neisseria gonorrhoeae","volume":"51","author":"Gaydos","year":"2013","journal-title":"J Clin Microbiol"},{"key":"2026041604061029100_ciaf699-B21","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1128\/JCM.00616-17","article-title":"Use of nucleic acid amplification testing for diagnosis of extragenital sexually transmitted infections","volume":"55","author":"Cosentino","year":"2017","journal-title":"J Clin Microbiol"},{"key":"2026041604061029100_ciaf699-B22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1071\/SH14158","article-title":"A field evaluation of a new molecular-based point-of-care test for chlamydia and gonorrhoea in remote Aboriginal health services in Australia","volume":"12","author":"Causer","year":"2015","journal-title":"Sex Health"},{"key":"2026041604061029100_ciaf699-B23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1136\/sextrans-2017-053443","article-title":"Molecular test for chlamydia and gonorrhoea used at point of care in remote primary healthcare settings: a diagnostic test evaluation","volume":"94","author":"Causer","year":"2018","journal-title":"Sex Transm Infect"},{"key":"2026041604061029100_ciaf699-B24","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3390\/pathogens12101268","article-title":"Pooled pharyngeal, rectal, and urine specimens for the point-of-care detection of Chlamydia trachomatis and Neisseria gonorrhoeae by lay providers in key population-led health services in Thailand","volume":"12","author":"Thammajaruk","year":"2023","journal-title":"Pathogens"},{"key":"2026041604061029100_ciaf699-B25","doi-asserted-by":"crossref","first-page":"e026888","DOI":"10.1136\/bmjopen-2018-026888","article-title":"Diagnostic accuracy of the Xpert CT\/NG and OSOM trichomonas rapid assays for point-of-care STI testing among young women in South Africa: a cross-sectional study","volume":"9","author":"Garrett","year":"2019","journal-title":"BMJ Open"},{"key":"2026041604061029100_ciaf699-B26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/sextrans-2017-053303","article-title":"Detection of Neisseria gonorrhoeae and Chlamydia trachomatis from pooled rectal, pharyngeal and urine specimens in men who have sex with men","volume":"94","author":"Speers","year":"2018","journal-title":"Sex Transm Infect"},{"key":"2026041604061029100_ciaf699-B27","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cmi.2018.08.001","article-title":"A diagnostic evaluation of a molecular assay used for testing and treating anorectal chlamydia and gonorrhoea infections at the point-of-care in Papua New Guinea","volume":"25","author":"Badman","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2026041604061029100_ciaf699-B28","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jemermed.2017.08.094","article-title":"Reliable rapid assay for gonorrhea and chlamydia in the emergency department","volume":"53","author":"Wilson","year":"2017","journal-title":"J Emerg Med"},{"key":"2026041604061029100_ciaf699-B29","doi-asserted-by":"crossref","first-page":"784610","DOI":"10.3389\/fcimb.2021.784610","article-title":"Clinical performance of the Xpert(\u00ae) CT\/NG test for detection of Chlamydia trachomatis and Neisseria gonorrhoeae: a multicenter evaluation in Chinese urban hospitals","volume":"11","author":"Han","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2026041604061029100_ciaf699-B30","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1473-3099(20)30734-9","article-title":"Performance of a single-use, rapid, point-of-care PCR device for the detection of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis: a cross-sectional study","volume":"21","author":"Morris","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"2026041604061029100_ciaf699-B31","doi-asserted-by":"crossref","first-page":"e204819","DOI":"10.1001\/jamanetworkopen.2020.4819","article-title":"Evaluation of the performance of a point-of-care test for chlamydia and gonorrhea","volume":"3","author":"Van Der Pol","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2026041604061029100_ciaf699-B32","first-page":"575","article-title":"Binx IO point-of-care test for Chlamydia trachomatis and Neisseria gonorrhoeae infections","volume":"106","author":"Clebak","year":"2022","journal-title":"Am Fam Physician"},{"key":"2026041604061029100_ciaf699-B33","doi-asserted-by":"crossref","first-page":"sextrans-2016","DOI":"10.1136\/sextrans-2016-052988","article-title":"Impact of deploying multiple point-of-care tests with a \u2018sample first\u2019 approach on a sexual health clinical care pathway: a service evaluation","volume":"93","author":"Harding-Esch","year":"2017","journal-title":"Sex Transm Infect"},{"key":"2026041604061029100_ciaf699-B34","doi-asserted-by":"crossref","first-page":"e0070625","DOI":"10.1128\/jcm.00706-25","article-title":"Sensitivity and specificity of the cobas liat CT\/NG\/MG nucleic acid test in a clinical laboratory setting and point-of-care location","volume":"63","author":"Van Der Pol","year":"2025","journal-title":"J Clin Microbiol"},{"key":"2026041604061029100_ciaf699-B35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.nurpra.2020.01.006","article-title":"Getting it right: the impact of point-of-care testing for gonorrhea and chlamydia in the urgent care setting","volume":"16","author":"Fisk","year":"2020","journal-title":"J Nurse Pract"},{"key":"2026041604061029100_ciaf699-B36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/OLQ.0000000000001586","article-title":"Clinical integration of a highly accurate polymerase chain reaction point-of-care test can inform immediate treatment decisions for chlamydia, gonorrhea, and trichomonas","volume":"49","author":"Dawkins","year":"2022","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B37","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/OLQ.0000000000000438","article-title":"A randomized controlled trial comparing the treatment of patients tested for chlamydia and gonorrhea after a rapid polymerase chain reaction test versus standard of care testing","volume":"43","author":"May","year":"2016","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B38","doi-asserted-by":"crossref","first-page":"ofaf749","DOI":"10.1093\/ofid\/ofaf749","article-title":"Real-world use of molecular point-of-care testing for Sexually Transmitted Infections (STIs) in the emergency department: why it matters for acute care management","volume":"13","author":"Dashler","year":"2025","journal-title":"Open Forum Infect Dis"},{"key":"2026041604061029100_ciaf699-B39","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/OLQ.0000000000000865","article-title":"Performance of the atlas genetics rapid test for Chlamydia trachomatis and women's attitudes toward point-of-care testing","volume":"45","author":"Widdice","year":"2018","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/OLQ.0000000000001083","article-title":"Patients are willing to wait for rapid sexually transmitted infection results in a university student health clinic","volume":"47","author":"Gettinger","year":"2020","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B41","doi-asserted-by":"crossref","first-page":"e91504","DOI":"10.1371\/journal.pone.0091504","article-title":"A laboratory-based evaluation of four rapid point-of-care tests for syphilis","volume":"9","author":"Causer","year":"2014","journal-title":"PLoS One"},{"key":"2026041604061029100_ciaf699-B42","doi-asserted-by":"crossref","first-page":"eabf6356","DOI":"10.1126\/scitranslmed.abf6356","article-title":"A portable magnetofluidic platform for detecting sexually transmitted infections and antimicrobial susceptibility","volume":"13","author":"Trick","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026041604061029100_ciaf699-B43","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/jac\/dkac242","article-title":"Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility","volume":"77","author":"Ayfan","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"2026041604061029100_ciaf699-B44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/JCM.01338-08","article-title":"Evaluation of the rapid BioStar optical immunoassay for detection of Chlamydia trachomatis in adolescent women","volume":"47","author":"Bandea","year":"2009","journal-title":"J Clin Microbiol"},{"key":"2026041604061029100_ciaf699-B45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1186\/s12879-016-1946-8","article-title":"Leucocyte esterase dip-stick test as a point-of-care diagnostic for urogenital chlamydia in male patients: a multi-center evaluation in two STI outpatient clinics in Paramaribo and Amsterdam","volume":"16","author":"Bartelsman","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2026041604061029100_ciaf699-B46","doi-asserted-by":"crossref","first-page":"949514","DOI":"10.3389\/fcimb.2022.949514","article-title":"Sensitive and visual identification of Chlamydia trachomatis using multiple cross displacement amplification integrated with a gold nanoparticle-based lateral flow biosensor for point-of-care use","volume":"12","author":"Chen","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2026041604061029100_ciaf699-B47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/OLQ.0000000000001913","article-title":"Development of a novel fluorescent-based lateral flow assay for the detection of Neisseria gonorrhoeae at the point of care","volume":"51","author":"Gleeson","year":"2024","journal-title":"Sex Transm Dis"},{"key":"2026041604061029100_ciaf699-B48","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(23)02240-7","article-title":"Novel lateral flow assay for point-of-care detection of Neisseria gonorrhoeae infection in syndromic management settings: a cross-sectional performance evaluation","volume":"403","author":"Peters","year":"2024","journal-title":"Lancet"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/82\/Supplement_1\/S43\/67091328\/ciaf699.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/82\/Supplement_1\/S43\/67091328\/ciaf699.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:06:27Z","timestamp":1776326787000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/82\/Supplement_1\/S43\/8496029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":48,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2026,2,24]]},"published-print":{"date-parts":[[2026,2,24]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaf699","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2,15]]},"published":{"date-parts":[[2026,2,15]]}}}