{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:50:10Z","timestamp":1786632610266,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We evaluated whether switching to bictegravir\/tenofovir alafenamide\/emtrictabine (BIC\/TAF\/FTC) or dolutegravir (DTG)\/tenofovir disoproxil fumarate (TDF)\/FTC in people with human immunodeficiency virus (PWH) with virological success increased risks of virological failure (VF), and if VF was driven by tenofovir resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysis embedded in the French national Dat\u2019AIDS cohort (NCT02898987) of all PWH followed after 1 January 2014, with no history of DTG and BIC exposure or resistance, and with a viral load &amp;lt;50\u2005copies\/mL for more than 12 months. Switchers changed their antiretroviral regimen to BIC\/TAF\/FTC or DTG + TDF\/FTC. VF defined as 1 value &amp;gt;200\u2005copies\/mL. Marginal structural models compared VF in switchers and nonswitchers, emulating a target trial. A multivariate Cox model assessed tenofovir resistance with VF in switchers only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a total of 9827 PWH, of whom 1393 (14.2%) switched to BIC\/TAF\/FTC or DTG + TDF\/FTC. We observed 75 (5.4%) VF in switchers and 523 (6.2%) in nonswitchers. After weighing, switching was associated with a nonsignificant risk of VF (hazard ratio [HR] 1.29; 95% CI: .97\u20131.7) (P = .08). Presence of possible resistance and resistance to tenofovir (ANRS resistance algorithm) was not associated with VF (HR 1.12; 95% CI: .82\u20131.5; P = .47) In switchers only, tenofovir resistance was not associated with VF (HR 1.04; 95% CI: .47\u20132.33), nor was M184V or M184I mutations (HR 0.98; 95% CI: .5\u20132.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a real-world setting, switching to BIC\/TAF\/FTC or DTG + TDF\/FTC in PWH with virological success was associated with a nonsignificant risk of VF, but M184V or M184I mutations and tenofovir resistance had no effect on VF. Most VF were blips or related to unmeasured adherence issues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaf726","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T12:50:15Z","timestamp":1766667015000},"page":"1007-1014","source":"Crossref","is-referenced-by-count":0,"title":["Switch to Bictegravir\/Tenofovir Alafenamide\/Emtrictabine or Dolutegravir + Tenofovir Disoproxil Fumarate\/Emtrictabine in Virologically Suppressed People With HIV: Outcomes in Real-world Setting With and Without Tenofovir Resistance"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-8444","authenticated-orcid":false,"given":"Alain","family":"Makinson","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, University Hospital Montpellier , Montpellier ,","place":["France"]},{"name":"Inserm U1175, TransVIHMI Unit, University of Montpellier , Montpellier 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