{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:20:48Z","timestamp":1788366048170,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacterial sexually transmitted infections, including syphilis, chlamydia, and gonorrhea, continue to rise in key populations despite prevention efforts. Doxycycline postexposure prophylaxis (doxy-PEP) has demonstrated efficacy in reducing syphilis and chlamydia in men who have sex with men and transgender women, with variable effects on gonorrhea depending on background levels of tetracycline resistance. However, some sexual health organizations recommend limiting widespread implementation because of antimicrobial resistance concerns. Given the demonstrated efficacy of doxy-PEP among men who have sex with men\/transgender women, implementation efforts should not be hindered by concerns related to antimicrobial resistance. Instead, efforts to reduce tetracycline use in animal feed are warranted, as are efforts to reduce overuse in other medical conditions. Doxy-PEP implementation should include efforts related to evaluation and monitoring of local antimicrobial resistance including Neisseria gonorrhoeae. This approach upholds the ethical principle of beneficence (providing efficacious care to patients) while addressing public health concerns related to antimicrobial resistance.<\/jats:p>","DOI":"10.1093\/cid\/ciag075","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:48:03Z","timestamp":1770382083000},"page":"285-288","source":"Crossref","is-referenced-by-count":1,"title":["Antimicrobial Resistance Concerns Should not Limit Doxycycline Postexposure Prophylaxis Implementation for Bacterial Sexually Transmitted Infection Prevention"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-1721","authenticated-orcid":false,"given":"Fady","family":"Mishriky","sequence":"first","affiliation":[{"name":"Open Door Health, Rhode Island Public Health Institute , Providence, Rhode Island ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A","family":"Chan","sequence":"additional","affiliation":[{"name":"Open Door Health, Rhode Island Public Health Institute , Providence, Rhode Island ,","place":["USA"]},{"name":"Brown University Department of Medicine, , Providence, Rhode Island ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"2026090211564290700_ciag075-B1","author":"World Health Organization"},{"key":"2026090211564290700_ciag075-B2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(17)30725-9","article-title":"Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial","volume":"18","author":"Molina","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2026090211564290700_ciag075-B3","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa2211934","article-title":"Postexposure doxycycline to prevent bacterial sexually transmitted infections","volume":"388","author":"Luetkemeyer","year":"2023","journal-title":"N Engl J Med"},{"key":"2026090211564290700_ciag075-B4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(25)00085-4","article-title":"Doxycycline to prevent bacterial sexually transmitted infections in the USA: final results from the DoxyPEP multicentre, open-label, randomised controlled trial and open-label extension","volume":"25","author":"Luetkemeyer","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"2026090211564290700_ciag075-B5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1473-3099(24)00236-6","article-title":"Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 \u00d7 2 factorial design","volume":"24","author":"Molina","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2026090211564290700_ciag075-B6","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1056\/NEJMoa2304007","article-title":"Doxycycline prophylaxis to prevent sexually transmitted infections in women","volume":"389","author":"Stewart","year":"2023","journal-title":"N Engl J Med"},{"key":"2026090211564290700_ciag075-B7","first-page":"1","article-title":"CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention, United States, 2024","volume":"73","author":"Bachmann","year":"2024","journal-title":"MMWR Recomm Rep Morb Mortal Wkly Rep Recomm Rep"},{"key":"2026090211564290700_ciag075-B8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1177\/09564624251352053","article-title":"British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025","volume":"36","author":"Saunders","year":"2025","journal-title":"Int J STD AIDS"},{"key":"2026090211564290700_ciag075-B9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5694\/mja2.52258","article-title":"Australian consensus statement on doxycycline post-exposure prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual and other men who have sex with men","volume":"220","author":"Cornelisse","year":"2024","journal-title":"Med J Aust"},{"key":"2026090211564290700_ciag075-B10","first-page":"466","article-title":"German STI Society (DSTIG). 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