{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:17:51Z","timestamp":1792513071681,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006292","name":"Infectious Diseases Society of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunocompromised individuals experience disproportionately severe outcomes from respiratory syncytial virus (RSV) infection, yet direct evidence to guide vaccination in this population remains limited. To support clinical and shared decision-making for the 2025\u20132026 respiratory virus season, the Infectious Diseases Society of America (IDSA) convened a multidisciplinary expert panel to develop rapid, evidence-based recommendations on RSV vaccination among immunocompromised adults and children. The panel conducted a systematic review of comparative effectiveness and harms data published between August 2024 and July 2025, supplemented by additional evidence from the Vaccine Integrity Project. Certainty of evidence and recommendation strength were assessed using the GRADE approach. Two test-negative case\u2013control studies in immunocompromised adults showed vaccination reduced RSV-associated hospitalization by 70% (95% CI: 66%\u201373%). Indirect evidence from older-adult populations demonstrated 81% effectiveness (95% CI: 52%\u201392%) against critical illness. Across three randomized trials, serious adverse events were comparable between vaccinated and unvaccinated groups. Guillain\u2013Barr\u00e9 syndrome was rare, with an estimated 11 excess cases per million doses. Given substantial reduction in severe disease and low likelihood of serious harm, the panel issued a strong recommendation for age-appropriate RSV vaccination in adults and adolescents with compromised immunity. For immunocompromised patients &amp;lt;18 years, shared decision-making is advised. Timing should be individualized by subgroups, considering treatment cycles, transplant status, and B-cell\u2013depleting therapies. Household members should remain up to date when eligible, and coadministration with influenza and coronavirus disease 2019 vaccines is acceptable. Research priorities include correlates of protection, durability of immunity, subgroup safety, and the role of booster doses.<\/jats:p>","DOI":"10.1093\/cid\/ciag117","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:55:37Z","timestamp":1772283337000},"page":"i123-i128","source":"Crossref","is-referenced-by-count":8,"title":["IDSA 2025 Guidelines on the Use of Vaccines for the Prevention of Seasonal RSV Infections in Immunocompromised Patients"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-0824","authenticated-orcid":false,"given":"Chen Sabrina","family":"Tan","sequence":"first","affiliation":[{"name":"University of Iowa Division of Infectious Diseases, Department of Medicine, Carver College of Medicine, , Iowa City, Iowa ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-1163","authenticated-orcid":false,"given":"Shweta","family":"Anjan","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine and Miami Transplant Institute Division of Infectious Diseases, , Miami, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella J","family":"Ariza-Heredia","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center Division of Internal Medicine, Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas, , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Magana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of General Internal Medicine and Infectious Diseases, The Ohio State University College of Medicine, Columbus, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D","family":"Minniear","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center Division of Pediatric Infectious Diseases, , Memphis, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Infectious Diseases Society of America Clinical Affairs and Practice Guidelines, , Arlington, Virginia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngve","family":"Falck-Ytter","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Faculty of Medicine, , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Baden","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School Division of Infectious Diseases, , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2026082412161625300_ciag117-B1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/vaccines11101611","article-title":"Vaccination recommendations in solid organ transplant adult candidates and recipients","volume":"11","author":"Vigan\u00f2","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"2026082412161625300_ciag117-B2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3390\/vaccines12121449","article-title":"Vaccination after haematopoietic stem cell transplant: a review of the literature and proposed vaccination protocol","volume":"12","author":"Silva-Pinto","year":"2024","journal-title":"Vaccines (Basel)"},{"key":"2026082412161625300_ciag117-B3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/acr.25045","article-title":"2022 American College of Rheumatology guideline for vaccinations in patients with rheumatic and musculoskeletal diseases","volume":"75","author":"Bass","year":"2023","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026082412161625300_ciag117-B4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/vaccines13030328","article-title":"Immunogenicity and safety of the bivalent respiratory syncytial virus prefusion F subunit vaccine in immunocompromised or renally impaired adults","volume":"13","author":"Almeida","year":"2025","journal-title":"Vaccines (Basel)"},{"key":"2026082412161625300_ciag117-B5","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1200\/JCO.24.00032","article-title":"Vaccination of adults with cancer: ASCO guideline","volume":"42","author":"Kamboj","year":"2024","journal-title":"J Clin Oncol"},{"key":"2026082412161625300_ciag117-B6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijid.2017.07.011","article-title":"Respiratory viruses in transplant recipients: more than just a cold. 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