{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:02:34Z","timestamp":1791396154596,"version":"4.3.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive meningococcal disease (IMD) is traditionally associated with younger populations, but its impact on older adults is rising. We aimed to describe the clinical characteristics and outcomes of critically ill older patients with IMD and identify risk factors for in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an ancillary analysis of the French nationwide multicenter RETRO-MENINGO cohort (2016\u20132024). All adults admitted to 102 ICUs with microbiologically confirmed IMD were included and stratified by age (\u226565 vs &amp;lt;65 years). The primary outcome was all-cause in-hospital mortality. Multivariable logistic regression identified factors independently associated with death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 654 patients, 114 (17%) were aged \u226565 years, of whom only 0.9% were reported as vaccinated. Compared to younger adults, older patients presented more frequently with hemodynamic failure and less often with classic purpura or meningeal symptoms. Serogroup W predominated in the older group, while serogroup B was more common in younger patients. Older adults required more organ support and had significantly higher in-hospital mortality (28.1%, n = 32\/114 vs 9.6%, n = 52\/540 P &amp;lt; .001). After adjustment, age \u2265 65 years remained independently associated with in-hospital mortality (aOR 2.99; 95% CI 1.57\u20135.72; P &amp;lt; .001), while administration of a third-generation cephalosporin before ICU admission was protective (aOR 0.45; 95% CI, .24\u2013.84; P = .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Critically ill older adults with IMD exhibit atypical clinical features, a high prevalence of serogroup W, and nearly triple the in-hospital mortality of younger patients. These findings emphasize the need for high clinical suspicion, rapid antibiotic therapy, and potential expansion of vaccination strategies to include older populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag133","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:34:12Z","timestamp":1771677252000},"page":"461-472","source":"Crossref","is-referenced-by-count":0,"title":["Invasive Meningococcal Disease in Adults Aged \u226565 Years Admitted to French Intensive Care Units: A Nationwide Comparison With Younger Adults"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-507X","authenticated-orcid":false,"given":"Damien","family":"Contou","sequence":"first","affiliation":[{"name":"R\u00e9animation polyvalente, Centre Hospitalier Victor Dupouy , Argenteuil , 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CHU de Bordeaux , Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Pirollet","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine intensive r\u00e9animation, CHU Michallon-Grenoble Alpes , La Tronche , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-9761","authenticated-orcid":false,"given":"Martin","family":"Cour","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine intensive r\u00e9animation, CHU Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamine","family":"Sarton","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation polyvalente, H\u00f4pital Purpan, CHU Toulouse , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gauvrit","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine intensive 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