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While control strategies have traditionally prioritized symptomatic cases, growing evidence highlights the substantial burden of asymptomatic or subclinical TB, microbiologically confirmed disease without classical symptoms, posing challenges for detection, treatment, and elimination efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a scoping review in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. We selected epidemiological studies, prevalence surveys, modeling analyses, and recent World Health Organization (WHO) guidance to summarize the current understanding of asymptomatic TB. We examined definitions, diagnostic approaches, transmission potential, natural history, and public health implications, with special focus on vulnerable populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence surveys reveal that up to 30%\u201350% of bacteriologically confirmed TB cases may be asymptomatic at diagnosis, many of whom remain undetected under symptom-based screening. A substantial fraction of these individuals is smear positive, underscoring their potential role in community transmission. Despite clinical silence, radiographic and molecular studies demonstrate ongoing lung pathology and immune activation, with 20%\u201330% progressing to symptomatic disease within 2 years. Diagnostic challenges include low bacillary burden and inability to expectorate sputum, though innovations, such as computer-aided radiography, sputum pooling, and host transcriptomic biomarkers, are advancing detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Asymptomatic TB represents a hidden but consequential component of the TB disease spectrum. Recognition and integration of this stage into TB control frameworks are essential for accurate burden estimation, timely treatment, and achievement of elimination targets. Future efforts must focus on scalable diagnostics, biomarker validation, and equitable screening strategies tailored to vulnerable populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag150","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:40:09Z","timestamp":1773924009000},"page":"S75-S84","source":"Crossref","is-referenced-by-count":7,"title":["Asymptomatic Tuberculosis Across the Disease Spectrum: A Scoping Review of Epidemiology, Diagnosis, and Public Health Implications"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-8328","authenticated-orcid":false,"given":"Beatriz Barreto","family":"Duarte","sequence":"first","affiliation":[{"name":"Institute for Research in Priority Populations (IRPP), Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative , Salvador ,","place":["Brazil"]},{"name":"Laboratory of Clinical and Translational Research, Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation , Salvador ,","place":["Brazil"]},{"name":"Instituto de Pesquisa Cl\u00ednica e Translacional, Medicina Zarns, Clariens Educa\u00e7\u00e3o , Salvador ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold","family":"Ellner","sequence":"additional","affiliation":[{"name":"South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine, Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia D","family":"Wright","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-1809","authenticated-orcid":false,"given":"Mark","family":"Hatherill","sequence":"additional","affiliation":[{"name":"South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine, Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-2718","authenticated-orcid":false,"given":"Amita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of International Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R","family":"Sterling","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajita","family":"Bhavaraju","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School , Global Tuberculosis Institute, Newark, New Jersey ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno B","family":"Andrade","sequence":"additional","affiliation":[{"name":"Institute for Research in Priority Populations (IRPP), Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative , Salvador ,","place":["Brazil"]},{"name":"Laboratory of Clinical and Translational Research, Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation , Salvador ,","place":["Brazil"]},{"name":"Instituto de Pesquisa Cl\u00ednica e Translacional, Medicina Zarns, Clariens Educa\u00e7\u00e3o , Salvador ,","place":["Brazil"]},{"name":"Division of Infectious Diseases, Department of Medicine, Johns Hopkins University , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of International Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"2026041316531316900_ciag150-B1"},{"key":"2026041316531316900_ciag150-B2","author":"Centers for Disease Control and Prevention."},{"key":"2026041316531316900_ciag150-B3"},{"key":"2026041316531316900_ciag150-B4","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/S0140-6736(25)00555-0","article-title":"Asymptomatic tuberculosis: undetected and underestimated, but not unimportant","volume":"405","author":"Dheda","year":"2025","journal-title":"Lancet"},{"key":"2026041316531316900_ciag150-B5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1164\/rccm.202006-2394PP","article-title":"The epidemiological importance of subclinical tuberculosis. 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