{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:07:28Z","timestamp":1779322048535,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"DOI":"10.1093\/cid\/ciag164","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:40:44Z","timestamp":1772800844000},"page":"e921-e922","source":"Crossref","is-referenced-by-count":0,"title":["Dolutegravir Appears to Lower Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) Proviral Load: The Emerging Rational Approach to Treatment of HTLV-1\u2013Associated Myelopathy"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-6548","authenticated-orcid":false,"given":"Eric A","family":"Meyerowitz","sequence":"first","affiliation":[{"name":"Montefiore Medical Center, Albert Einstein College of Medicine , Bronx, NewYork ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2026052019264848300_ciag164-B1","doi-asserted-by":"crossref","first-page":"15012","DOI":"10.1038\/nrdp.2015.12","article-title":"HTLV-1-associated myelopathy\/tropical spastic paraparesis","volume":"1","author":"Bangham","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2026052019264848300_ciag164-B2","first-page":"e910","article-title":"Dolutegravir Reduces Human T-Cell Lymphotropic Virus Type 1 Proviral Load and Improves Neurological Outcomes in a Phase 2 Controlled Trial","volume":"82","author":"Brites","year":"2026","journal-title":"Clin Infect Dis"},{"key":"2026052019264848300_ciag164-B3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/13550289809114225","article-title":"Analysis of HTLV-I proviral load in 202 HAM\/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM\/TSP","volume":"4","author":"Nagai","year":"1998","journal-title":"J Neurovirol"},{"key":"2026052019264848300_ciag164-B4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2007.09.006","article-title":"How does HTLV-I persist despite a strong cell-mediated immune response?","volume":"29","author":"Asquith","year":"2008","journal-title":"Trends Immunol"},{"key":"2026052019264848300_ciag164-B5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3390\/v2071427","article-title":"The HTLV-1 virological synapse","volume":"2","author":"Nejmeddine","year":"2010","journal-title":"Viruses"},{"key":"2026052019264848300_ciag164-B6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1212\/CPJ.0000000000000832","article-title":"Management of HAM\/TSP: systematic review and consensus-based recommendations 2019","volume":"11","author":"Araujo","year":"2021","journal-title":"Neurol Clin Pract"},{"key":"2026052019264848300_ciag164-B7","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1007\/s00415-024-12239-x","article-title":"Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy","volume":"271","author":"Sato","year":"2024","journal-title":"J Neurol"},{"key":"2026052019264848300_ciag164-B8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/pathogens9050342","article-title":"Antiretroviral therapy in HTLV-1 infection: an updated overview","volume":"9","author":"Marino-Merlo","year":"2020","journal-title":"Pathogens"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciag164\/67365210\/ciag164.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/82\/5\/e921\/67365210\/ciag164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/82\/5\/e921\/67365210\/ciag164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:26:55Z","timestamp":1779319615000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/82\/5\/e921\/8524572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3,9]]},"published-print":{"date-parts":[[2026,5,20]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciag164","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5,15]]},"published":{"date-parts":[[2026,3,9]]}}}