{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:13:31Z","timestamp":1790874811311,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068634"],"award-info":[{"award-number":["UM1AI068634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068636"],"award-info":[{"award-number":["UM1AI068636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI106701"],"award-info":[{"award-number":["UM1AI106701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69452"],"award-info":[{"award-number":["UM1AI69452"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69412"],"award-info":[{"award-number":["UM1AI69412"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69501"],"award-info":[{"award-number":["UM1AI69501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69423"],"award-info":[{"award-number":["UM1AI69423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69470"],"award-info":[{"award-number":["UM1AI69470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69432"],"award-info":[{"award-number":["UM1AI69432"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69465"],"award-info":[{"award-number":["UM1AI69465"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69419"],"award-info":[{"award-number":["UM1AI69419"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69471"],"award-info":[{"award-number":["UM1AI69471"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69494"],"award-info":[{"award-number":["UM1AI69494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69534"],"award-info":[{"award-number":["UM1AI69534"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69418"],"award-info":[{"award-number":["UM1AI69418"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69424"],"award-info":[{"award-number":["UM1AI69424"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69496"],"award-info":[{"award-number":["UM1AI69496"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69511"],"award-info":[{"award-number":["UM1AI69511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69481"],"award-info":[{"award-number":["UM1AI69481"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI69439"],"award-info":[{"award-number":["UM1AI69439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI154466"],"award-info":[{"award-number":["UM1AI154466"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI110527"],"award-info":[{"award-number":["P30AI110527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK020593"],"award-info":[{"award-number":["P30DK020593"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Integrase inhibitors (INSTI) and tenofovir alafenamide (TAF) have been associated with greater weight gain compared to nonnucleoside reverse transcriptase inhibitors (NNRTIs) and tenofovir disoproxil fumarate (TDF), but the effects of an antiretroviral regimen switch on weight are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 48-week, 3\u2013parallel group, open-label, multicenter, randomized controlled trial (NCT04636437) in people with HIV and obesity on an INSTI (bictegravir, dolutegravir, or raltegravir) with TAF\/emtricitabine (FTC) assessed whether switching to the NNRTI doravirine (DOR) with TAF\/FTC or TDF\/FTC results in weight loss or stabilization. Treatment effects were estimated using linear regression adjusted for sex, race, and entry weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 147 participants randomized, 145 initiated their assigned treatment. At entry, median age was 49 years; body mass index was 34.9 kg\/m2, and time on INSTI + TAF\/FTC was 3.4 years; 49% were female and 53% Black. After 48 weeks, the estimated mean change in weight was \u22120.47% (95% CI: \u22122.09, 1.14) for the DOR + TAF\/FTC arm, \u22122.73% (\u22124.22, \u22121.23) for DOR + TDF\/FTC, and \u22121.84% (\u22123.37, \u22120.30) for INSTI + TAF\/FTC. The estimated mean difference in weight change at 48 weeks for DOR versus INSTI (both with TAF\/FTC) was 1.36 percentage points (97.5% CI: \u22121.20, 3.92) and \u22120.89 percentage points (\u22123.34, 1.57) for DOR + TDF\/FTC versus INSTI + TAF\/FTC. There was no evidence of variation by sex or race, nor of treatment differences for changes in fasting lipids, insulin resistance, fat mass, or bone mineral density.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In people with HIV and obesity, switching from an INSTI + TAF\/FTC regimen to DOR\/FTC with either TAF or TDF did not produce clinically meaningful differences in weight change or metabolic health after 48 weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag196","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:08:01Z","timestamp":1773828481000},"page":"e81-e89","source":"Crossref","is-referenced-by-count":10,"title":["A 48-Week, Randomized Controlled Trial of Doravirine for Individuals With HIV and Obesity on Integrase Inhibitors and Tenofovir Alafenamide: The Do IT Study (ACTG A5391)"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-6942","authenticated-orcid":false,"given":"John R","family":"Koethe","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Division of Infectious Diseases, , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-5514","authenticated-orcid":false,"given":"Jordan E","family":"Lake","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston Division of Infectious Diseases, , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kantor","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health Center for Biostatistics in AIDS Research, , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7243-4703","authenticated-orcid":false,"given":"Laura","family":"Smeaton","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health Center for Biostatistics in AIDS Research, , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-6729","authenticated-orcid":false,"given":"Kristine","family":"Erlandson","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Division of Infectious Diseases, , Aurora, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Moran","sequence":"additional","affiliation":[{"name":"ACTG Network Coordinating Center , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-4734","authenticated-orcid":false,"given":"Pablo","family":"Belaunzaran-Zamudio","sequence":"additional","affiliation":[{"name":"Division of AIDS, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9645-1356","authenticated-orcid":false,"given":"Alan","family":"Landay","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch at Galveston Departments of Internal Medicine and Microbiology & Immunology, , Galveston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1190-461X","authenticated-orcid":false,"given":"Rafael E","family":"Campo","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc. Global Medical and Scientific Affairs, Merck Research Laboratories, , Rahway, New Jersey ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-0300","authenticated-orcid":false,"given":"Paula","family":"Debroy","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston Division of Infectious Diseases, , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8826-0453","authenticated-orcid":false,"given":"Jaclyn Ann","family":"Bennet","sequence":"additional","affiliation":[{"name":"Clinical HIV Research Unit, Internal Medicine Department, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"O'Halloran","sequence":"additional","affiliation":[{"name":"Center for Experimental Pathogen Host Research (CEPHR), University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-7960","authenticated-orcid":false,"given":"Win Min","family":"Han","sequence":"additional","affiliation":[{"name":"HIV-NAT, Thai Red Cross AIDS and Infectious Disease Research Centre , Bangkok ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladapo","family":"Alli","sequence":"additional","affiliation":[{"name":"Division of AIDS, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Leonard","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Division of Infectious Diseases, , Nashville, Tennessee ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-8912","authenticated-orcid":false,"given":"Roy M","family":"Gulick","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine Division of Infectious Diseases, , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"2026072309033324500_ciag196-B1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1089\/aid.2015.0147","article-title":"Rising obesity prevalence and weight gain among adults starting antiretroviral therapy in the United States and Canada","volume":"32","author":"Koethe","year":"2016","journal-title":"AIDS Res Hum Retroviruses"},{"key":"2026072309033324500_ciag196-B2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1186\/s12879-023-08736-5","article-title":"Prevalence of obesity, hypertension and diabetes among people living with HIV in South Africa: a systematic review and meta-analysis","volume":"23","author":"Gizamba","year":"2023","journal-title":"BMC Infect Dis"},{"key":"2026072309033324500_ciag196-B3","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cid\/cix998","article-title":"Multimorbidity among persons living with human immunodeficiency virus in the United States","volume":"66","author":"Wong","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B4","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1097\/QAD.0b013e32832bd7af","article-title":"HIV infection and the risk of diabetes mellitus","volume":"23","author":"Butt","year":"2009","journal-title":"AIDS"},{"key":"2026072309033324500_ciag196-B5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/QAI.0000000000001071","article-title":"Weight gain and incident diabetes among HIV-infected veterans initiating antiretroviral therapy compared with uninfected individuals","volume":"73","author":"Herrin","year":"2016","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026072309033324500_ciag196-B6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/QAD.0000000000000893","article-title":"The metabolic and cardiovascular consequences of obesity in persons with HIV on long-term antiretroviral therapy","volume":"30","author":"Koethe","year":"2016","journal-title":"AIDS"},{"key":"2026072309033324500_ciag196-B7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamainternmed.2013.3728","article-title":"HIV infection and the risk of acute myocardial infarction","volume":"173","author":"Freiberg","year":"2013","journal-title":"JAMA Intern Med"},{"key":"2026072309033324500_ciag196-B8","doi-asserted-by":"crossref","first-page":"e25484","DOI":"10.1002\/jia2.25484","article-title":"Weight gain among treatment-na\u00efve persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada","volume":"23","author":"Bourgi","year":"2020","journal-title":"J Int AIDS Soc"},{"key":"2026072309033324500_ciag196-B9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1902824","article-title":"Dolutegravir plus two different prodrugs of tenofovir to treat HIV","volume":"381","author":"Venter","year":"2019","journal-title":"New Engl J Med"},{"key":"2026072309033324500_ciag196-B10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/cid\/ciz999","article-title":"Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials","volume":"71","author":"Sax","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/QAD.0000000000002725","article-title":"Changes in weight and BMI with first-line doravirine-based therapy","volume":"35","author":"Orkin","year":"2021","journal-title":"AIDS"},{"key":"2026072309033324500_ciag196-B12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/hiv.70061","article-title":"Effectiveness of switching to doravirine-based antiretroviral therapy: a real-world study in Germany","volume":"26","author":"Wyen","year":"2025","journal-title":"HIV Med"},{"key":"2026072309033324500_ciag196-B13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12981-025-00761-5","article-title":"Weight loss with real-world doravirine use in the OPERA cohort: a US-based cohort study","volume":"22","author":"Mounzer","year":"2025","journal-title":"AIDS Res Ther"},{"key":"2026072309033324500_ciag196-B14","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/cid\/ciac949","article-title":"Weight and metabolic changes after switching from tenofovir alafenamide\/emtricitabine (FTC)+dolutegravir (DTG), tenofovir disoproxil fumarate (TDF)\/FTC + DTG, and TDF\/FTC\/efavirenz to TDF\/lamivudine\/DTG","volume":"76","author":"Bosch","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B15","first-page":"457","article-title":"2025 update of the drug resistance mutations in HIV-1","volume":"33","author":"Wensing","year":"2025","journal-title":"Top Antivir Med"},{"key":"2026072309033324500_ciag196-B16","author":"U.S. Department of Health and Human Services"},{"key":"2026072309033324500_ciag196-B17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cmet.2016.02.005","article-title":"Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity","volume":"23","author":"Magkos","year":"2016","journal-title":"Cell Metab"},{"key":"2026072309033324500_ciag196-B18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/cid\/ciae191","article-title":"Antiretrovirals and weight change: weighing the evidence","volume":"79","author":"Wohl","year":"2024","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/cid\/ciac130","article-title":"Efficacy and safety of switching to the 2-drug regimen dolutegravir\/lamivudine versus continuing a 3-or 4-drug regimen for maintaining virologic suppression in adults living with human immunodeficiency virus 1 (HIV-1): week 48 results from the phase 3, noninferiority SALSA randomized trial","volume":"76","author":"Llibre","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B20","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1093\/cid\/ciz1243","article-title":"Efficacy and safety of switching to dolutegravir\/lamivudine fixed-dose 2-drug regimen vs continuing a tenofovir alafenamide\u2013based 3-or 4-drug regimen for maintenance of virologic suppression in adults living with human immunodeficiency virus type 1: phase 3, randomized, noninferiority TANGO study","volume":"71","author":"Van Wyk","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B21","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1016\/S2352-3018(25)00105-5","article-title":"Maintenance therapy with dolutegravir and lamivudine versus bictegravir, emtricitabine, and tenofovir alafenamide in people with HIV (PASO-DOBLE): 48-week results from a randomised, multicentre, open-label, non-inferiority trial","volume":"12","author":"Ryan","year":"2025","journal-title":"The Lancet HIV"},{"key":"2026072309033324500_ciag196-B22","article-title":"Comparable inflammatory and metabolic outcomes after switching to bictegravir\/emtricitabine\/tenofovir alafenamide versus continuing dolutegravir\/lamivudine in virologically suppressed adults with HIV (INSTINCT\/GESIDA10918 study)","author":"Serrano-Villar","year":"2025","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B23","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/cid\/ciae449","article-title":"DEFINE: a prospective, randomized, phase 4 trial to assess a protease inhibitor-based regimen switch strategy to manage integrase inhibitor-related weight gain","volume":"80","author":"Anderson","year":"2025","journal-title":"Clin Infect Dis"},{"key":"2026072309033324500_ciag196-B24","doi-asserted-by":"crossref","first-page":"e220147","DOI":"10.2217\/cer-2022-0147","article-title":"Real-world weight changes in people with HIV-1 at risk of weight gain (female, Black or Hispanic) switching from integrase strand transfer inhibitors","volume":"12","author":"Donga","year":"2023","journal-title":"J Comp Eff Res"},{"key":"2026072309033324500_ciag196-B25","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1365-2125.2012.04440.x","article-title":"A phase 1 study to evaluate the effect of dolutegravir on renal function via measurement of iohexol and para-aminohippurate clearance in healthy subjects","volume":"75","author":"Koteff","year":"2013","journal-title":"Br J Clin Pharmacol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciag196\/67388222\/ciag196.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/83\/1\/e81\/67388222\/ciag196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/83\/1\/e81\/67388222\/ciag196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:03:42Z","timestamp":1784811822000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/83\/1\/e81\/8527356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,18]]},"published-print":{"date-parts":[[2026,7,23]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciag196","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7,15]]},"published":{"date-parts":[[2026,3,18]]}}}