{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:20:51Z","timestamp":1788366051449,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"DOI":"10.1093\/cid\/ciag226","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:27:45Z","timestamp":1775388465000},"page":"e455-e457","source":"Crossref","is-referenced-by-count":0,"title":["Understanding the Clinical Implications of the Barrier Against Resistance in Antiretroviral Treatment"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-6753","authenticated-orcid":false,"given":"Josep M","family":"Llibre","sequence":"first","affiliation":[{"name":"CIBER Epidemiology and Public Health (CIBERESP) , Barcelona ,","place":["Spain"]},{"name":"Centre of Epidemiological Studies of HIV\/AIDS and STI of Catalonia (CEEISCAT) , Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R","family":"Kuritzkes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-1970","authenticated-orcid":false,"given":"Raquel","family":"Martin-Iguacel","sequence":"additional","affiliation":[{"name":"Centre of Epidemiological Studies of HIV\/AIDS and STI of Catalonia (CEEISCAT) , Badalona, Spain"},{"name":"Department of Infectious Diseases, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-6668","authenticated-orcid":false,"given":"Diego","family":"Ripamonti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, ASST Papa Giovanni XXIII , Bergamo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-1808","authenticated-orcid":false,"given":"Ravindra K","family":"Gupta","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute , KwaZulu-Natal ,","place":["South Africa"]},{"name":"Department of Medicine, University of Cambridge , Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E","family":"Sax","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Schapiro","sequence":"additional","affiliation":[{"name":"National Hemophilia Center, Sheba Medical Center , Ramat Gan ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W","family":"Shafer","sequence":"additional","affiliation":[{"name":"Stanford University Medical School , Stanford, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-9128","authenticated-orcid":false,"given":"Thibault","family":"Mespl\u00e8de","sequence":"additional","affiliation":[{"name":"Viroscience Department, Erasmus University Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"2026090211581555400_ciag226-B1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/cid\/ciag225","article-title":"Resistance framing, temporal risk assumptions, and public health priorities in the long-acting antiretroviral era","volume":"83","author":"Buz\u00f3n-Mart\u00edn","year":"2026","journal-title":"Clin Infect Dis"},{"key":"2026090211581555400_ciag226-B2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/cid\/ciaf471","article-title":"Emergent human immunodeficiency virus type 1 (HIV-1) drug resistance in randomized trials of contemporary antiretroviral regimens","volume":"82","author":"Llibre","year":"2026","journal-title":"Clin Infect Dis"},{"key":"2026090211581555400_ciag226-B3","doi-asserted-by":"crossref","first-page":"e1008","DOI":"10.1093\/cid\/ciab086","article-title":"Participants on dolutegravir Resuppress Human Immunodeficiency Virus RNA after virologic failure: updated data from the ADVANCE trial","volume":"73","author":"Pepperell","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2026090211581555400_ciag226-B4","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s40121-025-01153-y","article-title":"Efficacy of bictegravir\/emtricitabine\/tenofovir alafenamide (B\/F\/TAF) after A viremic event: a pooled analysis of studies in people with HIV","volume":"14","author":"Pozniak","year":"2025","journal-title":"Infect Dis Ther"},{"key":"2026090211581555400_ciag226-B5","author":"U.S. Food & Drug Administration"},{"key":"2026090211581555400_ciag226-B6","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1128\/AAC.00691-12","article-title":"Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data","volume":"56","author":"Acosta","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2026090211581555400_ciag226-B7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/QAI.0000000000001306","article-title":"Antiviral activity, safety, and pharmacokinetics of bictegravir as 10-day monotherapy in HIV-1\u2013infected adults","volume":"75","author":"Gallant","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026090211581555400_ciag226-B8","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aea0947","article-title":"Lenacapavir treatment\u2013emergent HIV-1 capsid resistance mutations are frequently associated with replication defects","volume":"18","author":"Pennetzdorfer","year":"2026","journal-title":"Sci Transl Med"},{"key":"2026090211581555400_ciag226-B9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bpj.2024.11.1006","article-title":"Structural and mechanistic insights into cabotegravir (CAB) resistance in HIV-1 integrase","volume":"124","author":"Choudhuri","year":"2025","journal-title":"Biophys J"},{"key":"2026090211581555400_ciag226-B10","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/S2352-3018(24)00269-8","article-title":"Effectiveness of bi-monthly long-acting injectable cabotegravir and rilpivirine as maintenance treatment for HIV-1 in the Netherlands: results from the Dutch ATHENA national observational cohort","volume":"12","author":"Jonguen","year":"2025","journal-title":"Lancet HIV"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciag226\/67929511\/ciag226.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/83\/2\/e455\/67929511\/ciag226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/83\/2\/e455\/67929511\/ciag226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:58:24Z","timestamp":1788364704000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/83\/2\/e455\/8625788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,7]]},"published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciag226","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,15]]},"published":{"date-parts":[[2026,4,7]]}}}