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The composite incident hypertension outcome was defined as initiation of antihypertensive medication or \u22652 elevated blood pressures categorized as elevated (130\u2013139 and\/or 80\u201389 mmHg), mild (140\u2013159 and\/or 90\u201399 mmHg), moderate (\u2265160\u2013179 and\/or \u2265100\u2013109 mmHg), and severe (\u2265180 and\/or \u2265110 mmHg). Incident gestational hypertension was defined by initiation of antihypertensive medication or \u22652 blood pressures \u2265 140 and\/or \u226590 mmHg at \u226520 weeks GA with resolution by 12 weeks postpartum. Cox proportional hazard models were used for by-arm comparisons of the composite outcome and to look for the effect of weight change within arm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 626 women without baseline hypertension (median age 26.6 years), the composite incident outcome occurred in 49% (n = 308), predominantly due to the incident elevated category of elevated blood pressure, with no significant differences by arm, although hypertension was numerically more likely in the DTG arms. Each additional 5 kg of weight was associated with an 8%\u201317% higher hazard of the composite hypertension outcome. Twenty-seven participants (4.3%) had gestational hypertension with no apparent differences between arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data contribute information regarding the safety of DTG-based ART and TAF in pregnant and postpartum women and highlight the importance of monitoring weight and performing hypertension screening as part of maternal health care for young women with HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag245","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:49:46Z","timestamp":1775735386000},"page":"e331-e342","source":"Crossref","is-referenced-by-count":0,"title":["Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-4574","authenticated-orcid":false,"given":"Risa","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at the University of California , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Brummel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. 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