{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:06Z","timestamp":1792785846615,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24AI121296"],"award-info":[{"award-number":["K24AI121296"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI134637"],"award-info":[{"award-number":["R01AI134637"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI148342"],"award-info":[{"award-number":["R01AI148342"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01AI152999"],"award-info":[{"award-number":["P01AI152999"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI175699"],"award-info":[{"award-number":["1R01AI175699"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI185174"],"award-info":[{"award-number":["K23AI185174"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Houston Methodist Academic Institute","award":["#23550001"],"award-info":[{"award-number":["#23550001"]}],"id":[{"id":"https:\/\/ror.org\/027zt9171","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Candidemia is a common complication in hospitalized and critically ill patients. Nationwide US data on candidemia risk factors, species, antifungal resistance, and outcomes remain limited. Our objective was to describe candidemia trends from 2015 to 2024 and identify risk factors for Candida auris candidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study using the Epic Cosmos database. We analyzed trends in candidemia risk factors and outcomes. Thirty-day mortality was evaluated using multivariable logistic regression adjusted for age, Elixhauser comorbidity index, COVID-19\u2013related hospitalization, ICU-acquired candidemia, and calendar year. We compared characteristics of patients with C. auris vs. non-C. auris candidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 29 454 candidemia cases were identified among 27 926 unique patients; candidemia incidence increased over time (P = .02). Overall 30-day mortality was 31.5% and increased significantly over the study period (from 24.7% to 31.8%; P = .02). There were similar trends in in-hospital mortality (P = .01) and intensive care unit\u2013acquired candidemia (P = .03). The proportion of cases involving C. albicans decreased (P = .05) while C. auris cases increased (P = .008). Patients with C. auris candidemia were more likely to be Black, have renal failure, and have a higher social vulnerability index (P &amp;lt; .001 for all comparisons). Fluconazole resistance increased in C. parapsilosis (from 2.5% to 10.8%, P = .02) and C. tropicalis (from 6.2% to 18.1%, P = .03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Candidemia-associated 30-day mortality increased over the past decade, aligning with a trend toward older, more acutely ill patients developing candidemia. Candida auris candidemia was associated with Black race, higher social vulnerability, and renal failure. Overall, our findings highlight concerning nationwide US candidemia trends.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag312","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:45:54Z","timestamp":1778240754000},"page":"e505-e514","source":"Crossref","is-referenced-by-count":5,"title":["Changes in Epidemiology of Candidemia in the United States With a Focus on\n                    <i>Candida auris<\/i>"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-824X","authenticated-orcid":false,"given":"Mar\u00eda Alejandra","family":"P\u00e9rez","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7451-3103","authenticated-orcid":false,"given":"Khush A","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2644-4908","authenticated-orcid":false,"given":"Laila","family":"Rasmy","sequence":"additional","affiliation":[{"name":"McWilliams School of Biomedical Informatics, UTHealth at Houston , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisato","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences, University of Fukui , Fukui ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar A","family":"Arias","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , NewYork, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-1808","authenticated-orcid":false,"given":"Masayuki","family":"Nigo","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , NewYork, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-6046","authenticated-orcid":false,"given":"Max W","family":"Adelman","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , NewYork, New York ,","place":["USA"]},{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"2026100713442768800_ciag312-B1","doi-asserted-by":"crossref","first-page":"E449","DOI":"10.1093\/cid\/ciaa193","article-title":"Burden of candidemia in the United States, 2017","volume":"71","author":"Tsay","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2026100713442768800_ciag312-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7404a1","article-title":"Population-based active surveillance for culture-confirmed candidemia\u201410 sites, United States, 2017\u20132021","volume":"74","author":"Jenkins","year":"2025","journal-title":"MMWR Surveill Summ"},{"key":"2026100713442768800_ciag312-B3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmi.2019.04.024","article-title":"Morbidity and mortality of candidaemia in Europe: an epidemiologic meta-analysis","volume":"25","author":"Koehler","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2026100713442768800_ciag312-B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss6808a1","article-title":"Population-based active surveillance for culture-confirmed candidemia - 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