{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:41:59Z","timestamp":1788914519625,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021515","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021515","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Prudence Stanford"},{"name":"CMPP"},{"name":"Rebecca Lew"},{"name":"Eloquent"},{"name":"Envision Ignite"},{"name":"Envision Medical Communications"},{"name":"Envision Pharma Group"},{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Good Publication Practice"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extraintestinal pathogenic Escherichia coli (ExPEC) can colonize and infect body sites outside the intestines, which can lead to invasive E. coli disease potentially resulting in sepsis or death. We evaluated O-serotype distribution, antimicrobial resistance profiles, and sequence types (STs) of ExPEC bloodstream isolates collected during 17 global surveillance studies conducted from 2011 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>E. coli clinical blood isolates from an adult population were analyzed for O-serotype, ST, and multidrug resistance (MDR) using data obtained by agglutination, whole-genome sequencing, and determination of minimal inhibitory concentrations of antimicrobial drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Globally, 10 098 E. coli isolates were collected; 4925 (48.8%) from men and 5136 (50.9%) from women, median (range) age was 72 (18\u2013104) years. The most prevalent ExPEC O-serotypes were O25 (18.7%), O2 (8.2%), O6 (8.2%), and O1 (7.0%). Highest MDR rates were observed in India (83.3%), Mexico (76.6%), and China (69.4%); lowest rates were in Sweden (10.6%), New Zealand (11.6%), and the Netherlands (12.1%). Among MDR isolates (n = 3343), serotype O25 was the most prevalent in all countries (range: 11.3% China to 56.2% Mexico). We observed a resistance rate of 1.1% and 0.7% to last-resort carbapenem and colistin antibiotics, respectively, distributed over diverse STs and O-serotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, serotypes O25, O2, O6, and O1 were the most prevalent. MDR levels showed large regional variation. O25 was dominant within the subset of MDR isolates across all countries. O153-ST648, O101\/O162-ST744, O102-ST405, and O25-ST131 were associated with MDR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag453","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:48:08Z","timestamp":1785498488000},"source":"Crossref","is-referenced-by-count":1,"title":["Molecular Epidemiology and Drug Resistance of Extraintestinal Pathogenic\n                    <i>Escherichia coli<\/i>\n                    Bloodstream Isolates From Adults Worldwide (2011\u20132023)"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9789-5004","authenticated-orcid":false,"given":"Mark","family":"de Been","sequence":"first","affiliation":[{"name":"Janssen Vaccines & Prevention, Johnson & Johnson , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannisa","family":"Ritmahan","sequence":"additional","affiliation":[{"name":"Janssen Vaccines & Prevention, Johnson & 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