{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:37:07Z","timestamp":1792661827893,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/01333"],"award-info":[{"award-number":["PI23\/01333"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increasing heterogeneity among people with HIV requires evaluation of new follow-up strategies tailored to clinical\/social complexity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, single-center, randomized, noninferiority trial comparing semi-annual standard of care (SoC) with annual follow-upover 24 months in virologically suppressed people with HIV with low-complexity profile according to the GeSIDA HIV Patient Stratification System. The primary endpoint was noninferiority (prespecified lower margin: \u22124%) in virological control (viral load &amp;lt;50\u2005copies\/mL; FDA snapshot). Secondary outcomes included adherence, quality of life, satisfaction, and healthcare costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 394 eligible candidates, 71 declined participation (48% preferred SoC) and 321 were randomized (162 SoC, 159 Annual). Participants were predominantly male (89%), men who have sex with men (78%), Spanish (63%), with a median age of 45 years and 13 years of HIV follow-up, without baseline differences between groups. Overall, 283 (88%) completed the study; 25 switched to long-acting therapy and 10 were lost or transferred. Virological control was similar in SoC and annual arms: 86.42% vs 86.79% (intention to treat) and 98.29% vs 97.87% (per protocol), although noninferiority was not statistically demonstrated. The proportion of highly satisfied participants increased significantly from baseline to 24 months in the annual arm (P = .001). Reductions in HIV-related direct costs (\u221225.3%; P &amp;lt; .001) were greater in the Annual group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among people with HIV and low complexity, annual follow-up achieved virological outcomes clinically comparable to semi-annual care, despite not meeting the formal noninferiority threshold. Annual follow-up was associated with a significant increment in patient satisfaction and lower HIV-related direct costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag491","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:39:46Z","timestamp":1787053186000},"source":"Crossref","is-referenced-by-count":1,"title":["Annual vs Semi-Annual Follow-up in Low-Complexity, Virologically Suppressed People With HIV: A Randomized Interventional Trial"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-246X","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Chivite","sequence":"first","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Merino-Pe\u00f1as","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0894-3711","authenticated-orcid":false,"given":"Ana","family":"Gonz\u00e1lez-Cord\u00f3n","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-4101","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mart\u00ednez-Rebollar","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-4726","authenticated-orcid":false,"given":"Berta","family":"Torres","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-5206","authenticated-orcid":false,"given":"Lorena","family":"de la Mora","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-3457","authenticated-orcid":false,"given":"Alexy","family":"Inciarte","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-3186","authenticated-orcid":false,"given":"Alberto","family":"Foncillas","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-3766","authenticated-orcid":false,"given":"Julia","family":"Calvo","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-6686","authenticated-orcid":false,"given":"Juan","family":"Ambrosioni","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-9383","authenticated-orcid":false,"given":"Abiu","family":"Sempere","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-829X","authenticated-orcid":false,"given":"Leire","family":"Berrocal","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-2744","authenticated-orcid":false,"given":"Jos\u00e9 Lu\u00eds","family":"Blanco","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-7755","authenticated-orcid":false,"given":"Jos\u00e9 M","family":"Mir\u00f3","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Reial Academia de Medicina de Catalunya (RAMC) , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Llobet","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Fernandez","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-8846","authenticated-orcid":false,"given":"Esteban","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-141X","authenticated-orcid":false,"given":"Josep","family":"Mallolas","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2614-6545","authenticated-orcid":false,"given":"Elisa","family":"de Lazzari","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-6352","authenticated-orcid":false,"given":"Montserrat","family":"Laguno","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Cl\u00ednic Barcelona-Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"University of Barcelona Department of Medicine, Faculty of Medicine and Health Sciences, , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"2026102111380347900_ciag491-B1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(13)61809-7","article-title":"The end of AIDS: HIV infection as a chronic disease","volume":"382","author":"Deeks","year":"2013","journal-title":"Lancet"},{"key":"2026102111380347900_ciag491-B2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s11524-011-9552-y","article-title":"An epidemic in evolution: the need for new models of HIV care in the chronic disease era","volume":"88","author":"Chu","year":"2011","journal-title":"J Urban Health"},{"key":"2026102111380347900_ciag491-B3","author":"GeSIDA"},{"key":"2026102111380347900_ciag491-B4","volume-title":"EACS Guidelines version 13.0","author":"European AIDS Clinical Society (EACS)","year":"2025"},{"key":"2026102111380347900_ciag491-B5","volume-title":"Guidelines for the use of antiretroviral agents in adults and adolescents with HIV","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents","year":"2025"},{"key":"2026102111380347900_ciag491-B6","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1056\/NEJMcp1915826","article-title":"HIV infection\u2014screening, diagnosis, and treatment","volume":"384","author":"Saag","year":"2021","journal-title":"N Engl J Med"},{"key":"2026102111380347900_ciag491-B7","volume-title":"Policy brief on integrating and strengthening monitoring of differentiated ART service delivery","author":"World Health Organization","year":"2023"},{"key":"2026102111380347900_ciag491-B8","doi-asserted-by":"crossref","first-page":"22024","DOI":"10.7448\/IAS.20.5.22024","article-title":"Evidence for scale-up: the differentiated service delivery research agenda","volume":"20","author":"Grimsrud","year":"2017","journal-title":"J Int AIDS Soc"},{"key":"2026102111380347900_ciag491-B9","doi-asserted-by":"crossref","first-page":"e1305","DOI":"10.1016\/S2214-109X(20)30313-2","article-title":"Community-based antiretroviral therapy versus clinic-based care for HIV in sub-Saharan Africa (DO ART): a randomized trial","volume":"8","author":"Barnabas","year":"2020","journal-title":"Lancet Glob Health"},{"key":"2026102111380347900_ciag491-B10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/QAI.0000000000002333","article-title":"Six- versus three-monthly dispensing of antiretroviral treatment in stable HIV patients: a cluster-randomized trial","volume":"84","author":"Fatti","year":"2020","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026102111380347900_ciag491-B11","doi-asserted-by":"crossref","first-page":"e628","DOI":"10.1016\/S2214-109X(21)00039-5","article-title":"Extended refill intervals for antiretroviral therapy in Malawi (INTERVAL): a randomized trial","volume":"9","author":"Hoffman","year":"2021","journal-title":"Lancet Glob Health"},{"key":"2026102111380347900_ciag491-B12","doi-asserted-by":"crossref","first-page":"e25613","DOI":"10.1002\/jia2.25640","article-title":"Retention in care and viral suppression in differentiated service delivery models for HIV treatment","volume":"23","author":"Long","year":"2020","journal-title":"J Int AIDS Soc"},{"key":"2026102111380347900_ciag491-B13","first-page":"e0000166","article-title":"Economic evaluation of differentiated service delivery models for HIV treatment","volume":"2","author":"Rosen","year":"2022","journal-title":"PLOS Glob Public Health"},{"key":"2026102111380347900_ciag491-B14","volume-title":"Sistema de estratificaci\u00f3n de pacientes con VIH","author":"National Policy Project","year":"2020"},{"key":"2026102111380347900_ciag491-B15","volume-title":"HIV patient stratification system.","author":"Mora","year":"2020"},{"key":"2026102111380347900_ciag491-B16","volume-title":"Shared care of people living with HIV between primary and hospital care","author":"GeSIDA","year":"2022"},{"key":"2026102111380347900_ciag491-B17","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1046\/j.1525-1497.2000.03359.x","article-title":"The doctor-patient relationship and HIV-infected patients\u2019 satisfaction with primary care physicians","volume":"15","author":"Sullivan","year":"2000","journal-title":"J Gen Intern Med"},{"key":"2026102111380347900_ciag491-B18","first-page":"e081123","article-title":"CONSORT 2025 statement: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell","year":"2025","journal-title":"Lancet"},{"key":"2026102111380347900_ciag491-B19","volume-title":"EQ-5D-5L user guide","author":"EuroQol Foundation","year":"2019"},{"key":"2026102111380347900_ciag491-B20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/00002030-200203080-00012","article-title":"Validation of a simplified medication adherence questionnaire in a large cohort of HIV-infected patients: the GEEMA Study","volume":"16","author":"Knobel","year":"2002","journal-title":"AIDS"},{"key":"2026102111380347900_ciag491-B21","first-page":"46","article-title":"The one number you need to grow","volume":"81","author":"Reichheld","year":"2003","journal-title":"Harv Bus Rev"},{"key":"2026102111380347900_ciag491-B22","volume-title":"Human immunodeficiency virus-1 infection: developing antiretroviral drugs for treatment","author":"US Department of Health and Human Services, Food and Drug Administration","year":"2015"},{"key":"2026102111380347900_ciag491-B23","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap Consortium: building an international community of software partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"2026102111380347900_ciag491-B24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"2026102111380347900_ciag491-B25","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<873::AID-SIM779>3.0.CO;2-I","article-title":"Interval estimation for the difference between independent proportions: comparison of eleven methods","volume":"17","author":"Newcombe","year":"1998","journal-title":"Stat Med"},{"key":"2026102111380347900_ciag491-B26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41591-025-04041-7","article-title":"Cabotegravir and rilpivirine for treatment of HIV infection in Africa: week 96 results from the phase 3b randomized, open-label, noninferiority CARES trial","volume":"32","author":"Kityo","year":"2026","journal-title":"Nat Med"},{"key":"2026102111380347900_ciag491-B27","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0140-6736(23)01573-8","article-title":"Integrated management of HIV, diabetes, and hypertension in sub-Saharan Africa (INTE-AFRICA): a pragmatic cluster-randomised, controlled trial","volume":"402","author":"Kivuyo","year":"2023","journal-title":"Lancet"},{"key":"2026102111380347900_ciag491-B28","doi-asserted-by":"crossref","first-page":"103850","DOI":"10.1016\/j.eclinm.2026.103850","article-title":"Integrating clinical decision support and mobile health for differentiated HIV service delivery in Lesotho (VITAL): a cluster-randomised non-inferiority trial","volume":"94","author":"Tschumi","year":"2026","journal-title":"eClinicalMedicine"},{"key":"2026102111380347900_ciag491-B29","unstructured":"StataCorp\n          . Stata Statistical Software: Release 19. College Station, TX: StataCorp LLC; 2025."},{"key":"2026102111380347900_ciag491-B30","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"2026102111380347900_ciag491-B31","first-page":"339","article-title":"Concordance, validity and utility of the Andorran Triage Model (MAT)","volume":"15","author":"G\u00f3mez Jim\u00e9nez","year":"2003","journal-title":"Emergencias"},{"key":"2026102111380347900_ciag491-B32","first-page":"e580","article-title":"Impact of differentiated service delivery models on outcomes of HIV treatment and care: a systematic review","volume":"7","author":"Nichols","year":"2020","journal-title":"Lancet HIV"},{"key":"2026102111380347900_ciag491-B33","first-page":"e406","article-title":"Effect of community HIV care on HIV incidence, mortality, and population viral load (HPTN 071\/PopART)","volume":"9","author":"Limbada","year":"2022","journal-title":"Lancet HIV"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciag491\/70715581\/ciag491.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciag491\/70715581\/ciag491.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:38:12Z","timestamp":1792597092000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciag491\/8766647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1093\/cid\/ciag491","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"article-number":"ciag491"}}