{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:51:43Z","timestamp":1791604303733,"version":"4.3.4"},"reference-count":93,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients requiring long-term vascular access are at risk of experiencing recurrent or relapsing infections. Decisions to remove and replace these devices when infected depend on their clinical status, the pathogen involved, options for alternative access sites, the risk of mechanical complications or loss of access with attempted catheter replacement, and interruptions of care plans. This State-of-the-Art Review focuses on a team approach to the management of such complex patients. Management involves empiric and then directed systemic antimicrobial therapy, antimicrobial lock therapy, decisions regarding the use of antibiotic-impregnated catheters, and intentional preservation of central venous access for future device insertion. Meticulous documentation, a team approach to care including shared decision-making with the patient and family, optimization of available prophylactic medications and devices, and individualized adherence to evidence-based best practices and professional standards fill important gaps in care delivery and will improve the prevention and management of these infections in this vulnerable patient population.<\/jats:p>","DOI":"10.1093\/cid\/ciag559","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:54:20Z","timestamp":1789041260000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent and Relapsing Catheter-Related Bloodstream Infections in Patients Requiring Long-term Vascular Access"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8898-7406","authenticated-orcid":false,"given":"Leonard A","family":"Mermel","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Warren Alpert Medical School of Brown University , Providence, Rhode Island ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"Baskin","sequence":"additional","affiliation":[{"name":"Department of Radiology , Chicago Medical Center, Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Buetti","sequence":"additional","affiliation":[{"name":"Infection Control Program and World Health Organization Collaborating Centre, Faculty of Medicine, Geneva University Hospitals , Geneva ,","place":["Switzerland"]},{"name":"Infection, Antimicrobials, Modelling, Evolution, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Paris-Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-4275","authenticated-orcid":false,"given":"Kerry L","family":"LaPlante","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Rhode Island , Kingston, Rhode Island ,","place":["USA"]},{"name":"Infectious Diseases Research Program, Providence Veterans Affairs Medical Center , Providence, Rhode Island ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-3210","authenticated-orcid":false,"given":"Jonas","family":"Marschall","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Arizona College of Medicine \u2013 Phoenix , Phoenix, Arizona ,","place":["USA"]},{"name":"Banner University Medical Center \u2013 Phoenix, Banner Health , Phoenix, Arizona 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