{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:54:53Z","timestamp":1792616093934,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana, Spain","doi-asserted-by":"publisher","award":["CIPROM\/2024\/12"],"award-info":[{"award-number":["CIPROM\/2024\/12"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017642","name":"Spanish National Plan for Scientific and Technical Research and Innovation","doi-asserted-by":"publisher","award":["PI25\/01250"],"award-info":[{"award-number":["PI25\/01250"]}],"id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017642","name":"Spanish National Plan for Scientific and Technical Research and Innovation","doi-asserted-by":"publisher","award":["PI22\/01949"],"award-info":[{"award-number":["PI22\/01949"]}],"id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006301","name":"CIBER","doi-asserted-by":"publisher","award":["CB21\/13\/00011"],"award-info":[{"award-number":["CB21\/13\/00011"]}],"id":[{"id":"10.13039\/100006301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Uni\u00f3n Europea"},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer is an increasingly important cause of morbidity and mortality among people with human immunodeficiency virus (PWH), yet its impact on post-index-admission hospital trajectories remains poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide study using the mandatory Nationwide Hospital Discharge Database of the Spanish National Health System, including all adult hospital admissions from 1997 to 2023. We compared PWH and individuals without human immunodeficiency virus for trends in cancer-related hospitalizations, clinical characteristics, post-index-admission hospital trajectories, healthcare use, in-hospital mortality, and years of life lost (YLL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 115 171 334 admissions, 626 066 occurred in PWH. Cancer-related hospitalizations increased in both groups, but more steeply among PWH, reaching nearly 1 in 5 hospitalizations in 2020\u20132023. At first cancer admission, PWH were younger, had greater comorbidity, and more often had metastatic disease. Following cancer diagnosis, PWH had higher readmission risk, more frequent rehospitalizations, shorter time to readmission, longer cumulative stay, and higher hospitalization costs. A composite measure of complex hospital trajectory was more frequent among PWH (29.6% vs 18.0%; adjusted odds ratio [OR] 1.38, 95% CI 1.34\u20131.41). In-hospital mortality was higher (12.1% vs 8.9%; adjusted OR 1.83, 95% CI 1.79\u20131.87), and YLL were greater overall (35 vs 18 years) and across major cancer types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cancer has emerged as a major and growing driver of hospitalization among PWH, characterized by sustained excess hospital use, complex post-index-admission hospital trajectories, and substantially greater premature mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciag620","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:41:42Z","timestamp":1790682102000},"source":"Crossref","is-referenced-by-count":0,"title":["Excess Hospital Use and Years of Life Lost After Cancer Diagnosis Among People With HIV: A Nationwide Study in Spain"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9878-2458","authenticated-orcid":false,"given":"Mar","family":"Masi\u00e1","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"Universidad Miguel Hern\u00e1ndez de Elche Clinical Medicine Department, , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez-Ortiz de la Tabla","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario Infanta Leonor , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-3654","authenticated-orcid":false,"given":"Lidia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8022-364X","authenticated-orcid":false,"given":"Christian","family":"Ledesma","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"FISABIO, Hospital General Universitario de Elche , Elche ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-8504","authenticated-orcid":false,"given":"Marta","family":"Fern\u00e1ndez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Bello-Perez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"FISABIO, Hospital General Universitario de Elche , Elche ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-0935","authenticated-orcid":false,"given":"Paula","family":"Mascarell","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"Universidad Miguel Hern\u00e1ndez de Elche Clinical Medicine Department, , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-0030","authenticated-orcid":false,"given":"\u00c1ngela","family":"Botella","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5217-3726","authenticated-orcid":false,"given":"Javier","family":"Garc\u00eda-Abell\u00e1n","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"Universidad Miguel Hern\u00e1ndez de Elche Clinical Medicine Department, , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-7310","authenticated-orcid":false,"given":"Sergio","family":"Padilla","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"Universidad Miguel Hern\u00e1ndez de Elche Clinical Medicine Department, , Elche ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-6867","authenticated-orcid":false,"given":"F\u00e9lix","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche , Elche ,","place":["Spain"]},{"name":"Universidad Miguel Hern\u00e1ndez de Elche Clinical Medicine Department, , Elche 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