{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:59:33Z","timestamp":1791266373669,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,15]]},"DOI":"10.1093\/cid\/cir001","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T17:11:22Z","timestamp":1298481082000},"page":"695-706","source":"Crossref","is-referenced-by-count":85,"title":["Clinical Experience in Adults and Children Treated with Intravenous Peramivir for 2009 Influenza A (H1N1) Under an Emergency IND Program in the United States"],"prefix":"10.1093","volume":"52","author":[{"given":"Jaime E.","family":"Hernandez","sequence":"first","affiliation":[{"name":"ID Clinical Development, Clinical Pharmacology, and Clinical Development, BioCryst Pharmaceuticals, Durham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra","family":"Adiga","sequence":"additional","affiliation":[{"name":"Liberty Hospital, Liberty, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Good Samaritan Hospital, San Jose"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Bazan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Ohio State University Medical Center, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Summa Health System, Akron, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bradley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Rady Children's Hospital, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Dretler","sequence":"additional","affiliation":[{"name":"Dekalb Medical Center, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Ison","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Mangino","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Ohio State University Medical Center, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacene","family":"Maroushek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hennepin County Medical Center, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash K.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Wake Forest University Health Sciences, Winston-Salem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wald","sequence":"additional","affiliation":[{"name":"Department of Medicine, Epidemiology, and Laboratory Medicine, Division of Infectious Diseases, University of Washington Medical Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Ziebold","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, University of Iowa Children's Hospital, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Elder","sequence":"additional","affiliation":[{"name":"Pharpoint Research, Wilmington, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Hollister","sequence":"additional","affiliation":[{"name":"ID Clinical Development, Clinical Pharmacology, and Clinical Development, BioCryst Pharmaceuticals, Durham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Sheridan","sequence":"additional","affiliation":[{"name":"ID Clinical Development, Clinical Pharmacology, and Clinical Development, BioCryst Pharmaceuticals, Durham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the eIND Peramivir Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"key\n\t\t\t\t20180328171736_bib1","author":"Johnson","journal-title":"Determination that a public health emergency exists"},{"key":"key\n\t\t\t\t20180328171736_bib2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMra1000449","article-title":"Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection","volume":"362","author":"Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza","year":"2010","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328171736_bib3","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1056\/NEJMoa0906695","article-title":"Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009","volume":"361","author":"Jain","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328171736_bib4","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1001\/jama.2009.1536","article-title":"Critically ill patients with 2009 influenza A (H1N1) in Mexico","volume":"302","author":"Dominguez-Cherit","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180328171736_bib5","first-page":"749","article-title":"Intensive-care patients with severe novel influenza A (H1N1) virus infection. Michigan, June 2009","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key\n\t\t\t\t20180328171736_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0140-6736(09)61304-0","article-title":"H1N1 2009 influenza virus infection during pregnancy in the USA","volume":"374","author":"Jamieson","year":"2009","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328171736_bib7","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/jama.283.8.1016","article-title":"Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial","volume":"283","author":"Treanor","year":"2000","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180328171736_bib8","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1128\/AAC.00474-10","article-title":"Efficacy and safety of intravenous peramivir for the treatment of seasonal influenza","volume":"54","author":"Kohno","year":"2010","journal-title":"Antimicrob Agents Chermother"},{"key":"key\n\t\t\t\t20180328171736_bib9","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1086\/523584","article-title":"Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada","volume":"45","author":"McGeer","year":"2007","journal-title":"Clin Inf Dis"},{"key":"key\n\t\t\t\t20180328171736_bib10","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/thx.2009.130799","article-title":"Outcomes of adults hospitalized with severe influenza","volume":"65","author":"Lee","year":"2010","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20180328171736_bib11","author":"Centers for Disease Control and Prevention","journal-title":"Updated interim recommendations for the use of antiviral medications in the treatment and prevention of influenza for the 2009-2010 season"},{"key":"key\n\t\t\t\t20180328171736_bib12","article-title":"Antiviral treatment for patients hospitalized with 2009 pandemic influenza A (H1N1)","volume":"361","author":"Uyeki","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328171736_bib13","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1128\/AAC.45.4.1162-1167.2001","article-title":"Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir","volume":"45","author":"Bantia","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328171736_bib14","article-title":"Emergency use authorization of peramivir IV fact sheet for health care providers","author":"Centers for Disease Control and Prevention"},{"key":"key\n\t\t\t\t20180328171736_bib15","first-page":"A29","article-title":"A single intramuscular injection of peramivir demonstrates anti-influenza activity against recently isolated pandemic flu virus H1N1 (A\/CA\/04\/2009)","volume":"86","author":"Bantia","year":"2010","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20180328171736_bib16","article-title":"Therapeutic effect of peramivir (S-021812, BCX-1812) after single intravenous treatment of mice infected with influenza A and B viruses [abstract V-1065]","volume-title":"Program and abstracts of the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco)","author":"Yoshida","year":"2009"},{"issue":"suppl 1","key":"key\n\t\t\t\t20180328171736_bib17","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1016\/j.ijid.2010.02.1678","article-title":"Intravenous peramivir for treatment of influenza A and B infection in high-risk patients","volume":"14","author":"Kohno","year":"2010","journal-title":"Int J Infect Dis"},{"key":"key\n\t\t\t\t20180328171736_bib18","article-title":"Single-intravenous peramivir vs. oral oseltamivir to treat acute, uncomplicated influenza in the outpatient setting: a Phase III randomized, double-blind trial [abstract V-537a]","volume-title":"Program and abstracts of the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco)","author":"Kohno","year":"2009"},{"key":"key\n\t\t\t\t20180328171736_bib19","article-title":"Safety and efficacy of multiple-day treatment with intravenous peramivir or oral oseltamivir in hospitalized adults with acute influenza [abstract V-6]","volume-title":"Abstracts of the XI International Symposium on Respiratory Viral Infections (Bangkok)","author":"Ison","year":"2009"},{"key":"key\n\t\t\t\t20180328171736_bib20","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1056\/NEJMp0910479","article-title":"The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza","volume":"361","author":"Birnkrant","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328171736_bib21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1592\/phco.30.10.1016","article-title":"Pharmacokinetic monitoring of peramivir in two critically ill adult patients with 2009 H1N1 influenza A requiring continuous renal replacement therapy","volume":"30","author":"Bazan","year":"2010","journal-title":"Pharmacotherapy"},{"key":"key\n\t\t\t\t20180328171736_bib22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.7326\/0003-4819-152-9-201005040-00022","article-title":"Respiratory failure caused by 2009 novel influenza A\/H1N1 in a hematopoietic stem cell transplantation recipient: detection of extrapulmonary H1N1 RNA and use of intravenous peramivir","volume":"152","author":"Campbell","year":"2010","journal-title":"Ann Int Med"},{"key":"key\n\t\t\t\t20180328171736_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1542-4758.2010.00451.x","article-title":"Peramivir clearance in continuous renal replacement therapy [letter]","volume":"14","author":"Thomas","year":"2010","journal-title":"Hemodial Int"},{"key":"key\n\t\t\t\t20180328171736_bib24","article-title":"Pharmacokinetic and safety evaluations of escalating doses of peramivir administered intravenously in healthy volunteers [abstract A-1408]","volume-title":"Program and abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (Chicago)","author":"Beigel","year":"2007"},{"key":"key\n\t\t\t\t20180328171736_bib25","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1001\/jama.2009.1496","article-title":"Critically ill patients with 2009 influenza A (H1N1) infection in Canada","volume":"302","author":"Kumar","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180328171736_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1309\/AJCP35KOZSAVNQZW","article-title":"Autopsy findings in eight patients with fatal H1N1 influenza","volume":"134","author":"Harms","year":"2010","journal-title":"Amer J Clin Pathol"},{"key":"key\n\t\t\t\t20180328171736_bib27","article-title":"Safety and pharmacokinetics of peramivir following intravenous administration in subjects with renal impairment [abstract 623]","volume-title":"Program and abstracts of the 47th Annual Meeting of the Infectious Diseases Society of America (Philadelphia)","author":"Swan","year":"2009"},{"key":"key\n\t\t\t\t20180328171736_bib28","article-title":"the Peramivir Safety Team. [abstract V-648]","volume-title":"Program and abstracts of the 50th Interscience Conference on Antimicrobial agents and Chemotherapy (Boston).","author":"Sorbello","year":"2010"},{"key":"key\n\t\t\t\t20180328171736_bib29","doi-asserted-by":"crossref","first-page":"10366","DOI":"10.1128\/JVI.01200-09","article-title":"Zanamivir-resistant influenza viruses with a novel neuraminidase mutation","volume":"83","author":"Hurt","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20180328171736_bib30","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1001\/jama.2009.294","article-title":"Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States","volume":"301","author":"Dharan","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180328171736_bib31","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJMp0900648","article-title":"Global transmission of oseltamivir-resistant influenza","volume":"360","author":"Moscona","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328171736_bib32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.antiviral.2006.10.012","article-title":"Characterization of drug-resistant recombinant influenza A\/H1N1 viruses selected in vitro with peramivir and zanamivir","volume":"74","author":"Baz","year":"2007","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20180328171736_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0166-3542(01)00219-4","article-title":"Susceptibility of recent Canadian influenza A and B virus isolates to different neuraminidase inhibitors","volume":"54","author":"Boivin","year":"2002","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20180328171736_bib34","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1086\/651605","article-title":"Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts","volume":"50","author":"Memoli","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328171736_bib35","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1086\/652655","article-title":"Use of intravenous zanamivir after development of oseltamivir resistance in a critically ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus","volume":"50","author":"Dulek","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328171736_bib36","article-title":"Antiviral treatment options, including intravenous peramivir, for treatment of influenza in hospitalized patients for the 2009-2010 season","author":"Centers for Disease Control and Prevention"},{"key":"key\n\t\t\t\t20180328171736_bib37","doi-asserted-by":"crossref","first-page":"A47","DOI":"10.1016\/j.antiviral.2010.02.413","article-title":"Efficacy of combinations of oseltamivir and peramivir in treating influenza a (H1N1) virus infections in cell culture and in mice","volume":"86","author":"Smee","year":"2010","journal-title":"Antiviral Res"},{"key":"key\n\t\t\t\t20180328171736_bib38","article-title":"Absence of pharmacokinetic (PK) interaction between intravenous (IV) peramivir and oral (PO) rimantidine or oseltamivir in humans [abstract A1-2001]","volume-title":"Program and abstracts of the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (Boston)","author":"Lasseter","year":"2010"},{"key":"key\n\t\t\t\t20180328171736_bib39"},{"key":"key\n\t\t\t\t20180328171736_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/135965350300800301","article-title":"Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza","volume":"8","author":"Ison","year":"2003","journal-title":"Antivir Ther"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/52\/6\/695\/13802847\/cir001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T06:56:47Z","timestamp":1685948207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/52\/6\/695\/364156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,15]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,3,15]]},"published-print":{"date-parts":[[2011,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cir001","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,3,15]]},"published":{"date-parts":[[2011,3,15]]}}}