{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:23:23Z","timestamp":1791325403457,"version":"4.3.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"DOI":"10.1093\/cid\/cis358","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T20:19:01Z","timestamp":1341260341000},"page":"S127-S131","source":"Crossref","is-referenced-by-count":98,"title":["Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis"],"prefix":"10.1093","volume":"55","author":[{"given":"Irina","family":"Artsimovitch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Seddon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"key\n\t\t\t\t20171014010352_CIS358C1","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1039\/p19870001353","article-title":"Structure elucidation of the macrocyclic antibiotic lipiarmycin","volume":"6","author":"Arnone","year":"1987","journal-title":"J Chem Soc Perkin Trans I"},{"key":"key\n\t\t\t\t20171014010352_CIS358C2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.7164\/antibiotics.41.308","article-title":"Structure and biological activity of lipiarmycin B","volume":"41","author":"Cavalleri","year":"1988","journal-title":"J Antibiot (Tokyo)"},{"key":"key\n\t\t\t\t20171014010352_CIS358C3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/jac\/dkn269","article-title":"Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis","volume":"62","author":"Kurabachew","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20171014010352_CIS358C4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7164\/antibiotics.28.247","article-title":"Lipiarmycin, a new antibiotic from Actinoplanes. I. Description of the producer strain and fermentation studies","volume":"28","author":"Parenti","year":"1975","journal-title":"J Antibiot (Tokyo)"},{"key":"key\n\t\t\t\t20171014010352_CIS358C5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.7164\/antibiotics.28.543","article-title":"Lipiarmycin, a new antibiotic from Actinoplanes. III. Mechanism of action","volume":"28","author":"Sergio","year":"1975","journal-title":"J Antibiot (Tokyo)"},{"key":"key\n\t\t\t\t20171014010352_CIS358C6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-2836(79)90459-5","article-title":"Initiation of transcription in vitro inhibited by lipiarmycin","volume":"127","author":"Sonenshein","year":"1979","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20171014010352_CIS358C7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0006-291X(75)80047-7","article-title":"Lipiarmycin: an antibiotic inhibiting nucleic acid polymerases","volume":"63","author":"Talpaert","year":"1975","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20171014010352_CIS358C8","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jmb.2009.10.063","article-title":"Molecular evolution of multisubunit RNA polymerases: structural analysis","volume":"395","author":"Lane","year":"2010","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20171014010352_CIS358C9","first-page":"699","article-title":"Chemical modifications and biological properties of rifamycins","volume":"6","author":"Sensi","year":"1966","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171014010352_CIS358C10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cell.2005.07.014","article-title":"Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins","volume":"122","author":"Artsimovitch","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0092-8674(01)00286-0","article-title":"Structural mechanism for rifampicin inhibition of bacterial RNA polymerase","volume":"104","author":"Campbell","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C12","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1128\/jb.173.6.2120-2124.1991","article-title":"Purification and characterization of the DNA-dependent RNA polymerase from Clostridium acetobutylicum","volume":"173","author":"Pich","year":"1991","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20171014010352_CIS358C13","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1016\/S0021-9258(18)63520-3","article-title":"A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase","volume":"244","author":"Burgess","year":"1969","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171014010352_CIS358C14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.molcel.2005.07.020","article-title":"Structural basis of transcription inhibition by antibiotic streptolydigin","volume":"19","author":"Temiakov","year":"2005","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cell.2005.07.017","article-title":"Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation","volume":"122","author":"Tuske","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C16","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nsmb1015","article-title":"Structural basis for transcription inhibition by tagetitoxin","volume":"12","author":"Vassylyev","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"key\n\t\t\t\t20171014010352_CIS358C17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molcel.2004.05.017","article-title":"Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25","volume":"14","author":"Adelman","year":"2004","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molcel.2004.06.010","article-title":"Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel","volume":"14","author":"Mukhopadhyay","year":"2004","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C19","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.1087526","article-title":"A new class of bacterial RNA polymerase inhibitor affects nucleotide addition","volume":"302","author":"Artsimovitch","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20171014010352_CIS358C20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/sj.emboj.7600499","article-title":"Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase","volume":"24","author":"Campbell","year":"2005","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20171014010352_CIS358C21","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/emboj.2010.135","article-title":"The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site","volume":"29","author":"Tupin","year":"2010","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20171014010352_CIS358C22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature07510","article-title":"Transcription inactivation through local refolding of the RNA polymerase structure","volume":"457","author":"Belogurov","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171014010352_CIS358C23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2008.09.033","article-title":"The RNA polymerase \u201cswitch region\u201d is a target for inhibitors","volume":"135","author":"Mukhopadhyay","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jmb.2011.01.018","article-title":"Mechanism of bacterial transcription initiation: RNA polymerase-promoter binding, isomerization to initiation-competent open complexes, and initiation of RNA synthesis","volume":"412","author":"Saecker","year":"2011","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20171014010352_CIS358C25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(00)81515-9","article-title":"Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution","volume":"98","author":"Zhang","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171014010352_CIS358C26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1101\/gad.1745409","article-title":"Allosteric control of Escherichia coli rRNA promoter complexes by DksA","volume":"23","author":"Rutherford","year":"2009","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20171014010352_CIS358C27","article-title":"Transcription inhibition by fidaxomicin [poster]","author":"Seddon"},{"key":"key\n\t\t\t\t20171014010352_CIS358C28","article-title":"Resistance development, cross-resistance, and synergy studies of OPT-80 [poster]","author":"Babakhani"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/55\/suppl_2\/S127\/20911053\/cis358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T02:17:56Z","timestamp":1642645076000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/cid\/article\/55\/suppl_2\/S127\/436190\/Fidaxomicin-Is-an-Inhibitor-of-the-Initiation-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,1]]},"references-count":28,"journal-issue":{"issue":"suppl_2","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cis358","relation":{},"ISSN":["1537-6591","1058-4838"],"issn-type":[{"value":"1537-6591","type":"electronic"},{"value":"1058-4838","type":"print"}],"subject":[],"published-other":{"date-parts":[[2012,8,1]]},"published":{"date-parts":[[2012,8,1]]}}}