{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:21Z","timestamp":1791404901426,"version":"4.3.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"DOI":"10.1093\/cid\/cis486","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T11:23:48Z","timestamp":1337513028000},"page":"621-630","source":"Crossref","is-referenced-by-count":97,"title":["Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"55","author":[{"given":"Sabine","family":"Mand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Yaw","family":"Debrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Klarmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Batsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeboah","family":"Marfo-Debrekyei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kwarteng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Specht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea","family":"Belda-Domene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Fimmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohene","family":"Adjei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,18]]},"reference":[{"key":"key\n\t\t\t\t20170612092910_CIS486C1","article-title":"GPELF progress report 2000-2009 and strategic plan 2010\u20132020","author":"WHO"},{"key":"key\n\t\t\t\t20170612092910_CIS486C2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0035-9203(99)90140-2","article-title":"Acute attacks in the extremities of persons living in an area endemic for bancroftian filariasis: differentiation of two syndromes","volume":"93","year":"1999","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170612092910_CIS486C3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2883-6-2","article-title":"Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature","volume":"6","year":"2007","journal-title":"Filaria J"},{"key":"key\n\t\t\t\t20170612092910_CIS486C4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1756-3305-3-100","article-title":"The 6th Meeting of the Global Alliance to Eliminate Lymphatic Filariasis: a half-time review of lymphatic filariasis elimination and its integration with the control of other neglected tropical diseases","volume":"3","year":"2010","journal-title":"Parasit Vectors"},{"key":"key\n\t\t\t\t20170612092910_CIS486C5","volume-title":"Basic lymphoedema management: treatment and prevention of problems associated with lymphatic filariasis","year":"2002"},{"key":"key\n\t\t\t\t20170612092910_CIS486C6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0035-9203(95)90049-7","article-title":"Direct assessment of the adulticidal efficacy of a single dose of ivermectin in bancroftian filariasis","volume":"89","year":"1995","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170612092910_CIS486C7","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1371\/journal.ppat.0020092","article-title":"Doxycycline reduces plasma VEGF-C\/sVEGFR-3 and improves pathology in lymphatic filariasis","volume":"2","year":"2006","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170612092910_CIS486C8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0035-9203(00)90135-4","article-title":"Single-dose treatment of Wuchereria bancrofti infections with ivermectin and albendazole alone or in combination: evaluation of the potential for control at 12 months after treatment","volume":"94","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170612092910_CIS486C9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-3156.2005.01389.x","article-title":"Lymphatic filariasis in Ghana: establishing the potential for an urban cycle of transmission","volume":"10","year":"2005","journal-title":"Trop Med Int Health"},{"key":"key\n\t\t\t\t20170612092910_CIS486C10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/00034983.1999.11813433","article-title":"A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis","volume":"93","year":"1999","journal-title":"Ann Trop Med Parasitol"},{"key":"key\n\t\t\t\t20170612092910_CIS486C11","article-title":"Lymphatic Filariasis: the disease and its control","author":"WHO","year":"1992","journal-title":"Tech Rep Ser"},{"key":"key\n\t\t\t\t20170612092910_CIS486C12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-2883-2-3","article-title":"Animated documentation of the filaria dance sign (FDS) in bancroftian filariasis","volume":"2","year":"2003","journal-title":"Filaria J"},{"key":"key\n\t\t\t\t20170612092910_CIS486C13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.phrs.2010.10.007","article-title":"Clinical applications of non-antimicrobial tetracyclines in dermatology","volume":"63","year":"2011","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20170612092910_CIS486C14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"key\n\t\t\t\t20170612092910_CIS486C15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1874210600802010005","article-title":"A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: a literature review","volume":"2","year":"2008","journal-title":"Open Dent J"},{"key":"key\n\t\t\t\t20170612092910_CIS486C16","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1096\/fj.08-110494","article-title":"Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability","volume":"22","year":"2008","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170612092910_CIS486C17","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.fertnstert.2008.08.129","article-title":"Doxycycline inhibits vascular leakage and prevents ovarian hyperstimulation syndrome in a murine model","volume":"92","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170612092910_CIS486C18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/10454411910020030201","article-title":"Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs","volume":"2","year":"1991","journal-title":"Crit Rev Oral Biol Med"},{"key":"key\n\t\t\t\t20170612092910_CIS486C19","doi-asserted-by":"crossref","first-page":"956","DOI":"10.4269\/ajtmh.2009.80.956","article-title":"Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline","volume":"80","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170612092910_CIS486C20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4269\/ajtmh.2009.09-0155","article-title":"Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine","volume":"81","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170612092910_CIS486C21","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/S0140-6736(05)66591-9","article-title":"Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial","volume":"365","year":"2005","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170612092910_CIS486C22","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0140-6736(00)02095-X","article-title":"Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis","volume":"355","year":"2000","journal-title":"Lancet"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/55\/5\/621\/17701760\/cis486.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:57:01Z","timestamp":1743145021000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article-lookup\/doi\/10.1093\/cid\/cis486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,18]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,18]]},"published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cis486","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717297831.792652841","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717297831.792802806","asserted-by":"object"}]},"ISSN":["1537-6591","1058-4838"],"issn-type":[{"value":"1537-6591","type":"electronic"},{"value":"1058-4838","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5,18]]}}}