{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:08Z","timestamp":1791239048438,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,15]]},"DOI":"10.1093\/cid\/cis529","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T22:14:15Z","timestamp":1338934455000},"page":"789-798","source":"Crossref","is-referenced-by-count":184,"title":["Clinical Manifestations of Cryptococcus gattii Infection: Determinants of Neurological Sequelae and Death"],"prefix":"10.1093","volume":"55","author":[{"given":"Sharon C-A.","family":"Chen","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, Sydney"},{"name":"The Sydney Institute for Emerging Infections and Biosecurity, University of Sydney"},{"name":"Westmead Hospital, Western Sydney Local Health District"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Slavin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, Royal Perth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Geoffrey","family":"Playford","sequence":"additional","affiliation":[{"name":"Infection Management Services, Princess Alexandra Hospital, Brisbane"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Byth","sequence":"additional","affiliation":[{"name":"Westmead Hospital, Western Sydney Local Health District"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Marriott","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Kidd","sequence":"additional","affiliation":[{"name":"Mycology Unit, SA Pathology at Women's and Children's Hospital, Adelaide"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narin","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Royal Adelaide Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Currie","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department and Menzies School of Health Research, Royal Darwin Hospital, Casuarina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krispin","family":"Hajkowicz","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department and Menzies School of Health Research, Royal Darwin Hospital, Casuarina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony M.","family":"Korman","sequence":"additional","affiliation":[{"name":"Monash Infectious Diseases and Monash University, Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J. H.","family":"McBride","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, James Cook University, Cairns, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Meyer","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, Sydney"},{"name":"The Sydney Institute for Emerging Infections and Biosecurity, University of Sydney"},{"name":"Molecular Mycology Research Laboratory, Westmead Hospital, University of Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine WA"},{"name":"Department of Infectious Diseases, Sir Charles Gairdner Hospital, Perth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania C.","family":"Sorrell","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, Sydney"},{"name":"The Sydney Institute for Emerging Infections and Biosecurity, University of Sydney"},{"name":"Westmead Hospital, Western Sydney Local Health District"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Australia and New Zealand Mycoses Interest Group (ANZMIG)-Cryptococcus Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"key\n\t\t\t\t20180328143056_CIS529C1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/14656566.9.4.551","article-title":"Epidemiology and management of cryptococcocal meningitis: developments and challenges","volume":"9","author":"Pukkila-Worley","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"key\n\t\t\t\t20180328143056_CIS529C2","doi-asserted-by":"crossref","DOI":"10.1128\/9781555816858","volume-title":"Cryptococcus from human pathogen to model yeast","author":"Heitman","year":"2011"},{"key":"key\n\t\t\t\t20180328143056_CIS529C3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/clinids\/20.3.611","article-title":"Cryptococcal disease of the CNS in immunocompetent hosts: influence of cryptococcal variety on clinical manifestations and outcome","volume":"20","author":"Mitchell","year":"1995","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1086\/313992","article-title":"Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand","volume":"31","author":"Chen","year":"2000","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/mmy.39.2.155.168","article-title":"Cryptococcus neoformans variety gattii","volume":"39","author":"Sorrell","year":"2001","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20180328143056_CIS529C6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3201\/eid1301.060827","article-title":"Spread of Cryptococcus gattii in British Columbia, Canada, and detection in the Pacific Northwest, USA","volume":"13","author":"MacDougall","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3201\/eid1602.090900","article-title":"Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999\u20132007","volume":"16","author":"Galanis","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C8","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3201\/eid1508.081384","article-title":"Spread of Cryptococcus gattii into the Pacific Northwest region of the United States","volume":"15","author":"Datta","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3201\/eid1702.101020","article-title":"Risk factors for Cryptococcus gattii infection, British Columbia","volume":"17","author":"MacDougall","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C10","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/cid\/cir723","article-title":"Cryptococcus gattii in the United States: clinical aspects of infection with an emerging pathogen","volume":"53","author":"Harris","year":"2011","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C11","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/cid\/cir738","article-title":"Cryptococcus gattii: the tip of the iceberg","volume":"53","author":"Marr","year":"2011","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1155\/2009\/719659","article-title":"Clinical presentation, diagnosis and management of Cryptococcus gattii cases: lessons learned from British Columbia","volume":"20","author":"Galanis","year":"2009","journal-title":"Can J Dis Med Microbiol"},{"key":"key\n\t\t\t\t20180328143056_CIS529C13","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1128\/JCM.42.8.3865-3868.2004","article-title":"Cryptococcus infection in tropical Australia","volume":"42","author":"Jenny","year":"2004","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180328143056_CIS529C14","volume-title":"International statistical classification of disease and related health problems, 10th revision, Australian Modification (ICD-10-AM)","year":"1998"},{"key":"key\n\t\t\t\t20180328143056_CIS529C15","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.pmed.0040021","article-title":"Determinants of disease presentation and outcome during cryptococcosis: the CryptoA\/D Study","volume":"4","author":"Dromer","year":"2007","journal-title":"PLoS Medicine"},{"key":"key\n\t\t\t\t20180328143056_CIS529C16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C17","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1086\/503903","article-title":"Immune reconstitution syndrome in HIV: validating a case definition and identifying clinical predictors in persons initiating antiretroviral therapy","volume":"42","author":"Robertson","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C18","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/01.aids.0000174450.70874.30","article-title":"Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France","volume":"19","author":"Lortholary","year":"2005","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180328143056_CIS529C19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJM199302113280601","article-title":"Unexplained opportunistic infections and CD4+ T-lymphopenia without HIV infection. An investigation of cases in the United States. the Centers for Disease Control idiopathic CD4+ T-lymphocytopenia task force","volume":"328","author":"Smith","year":"1993","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328143056_CIS529C20","first-page":"62","article-title":"Candida, Cryptococcus, and other yeasts of medical importance","volume-title":"Manual of clinical microbiology","author":"Hazen","year":"2007"},{"key":"key\n\t\t\t\t20180328143056_CIS529C21","article-title":"Census of Population and Housing","author":"Australian Bureau of Statistics"},{"key":"key\n\t\t\t\t20180328143056_CIS529C22","article-title":"Tobacco smoking in Australia: a snapshot, 2004\u20132005","author":"Australian Bureau of Statistics"},{"key":"key\n\t\t\t\t20180328143056_CIS529C23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1086\/322597","article-title":"Cryptococcus in human immunodeficiency virus-negative patients in the era of effective azole therapy","volume":"33","author":"Pappas","year":"2001","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C24","author":"Australian Bureau of Statistics"},{"key":"key\n\t\t\t\t20180328143056_CIS529C25","article-title":"Diabetes in Australia: a snapshot, 2004\u201305.","author":"Australian Bureau of Statistics"},{"key":"key\n\t\t\t\t20180328143056_CIS529C26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/clinids\/21.1.28","article-title":"Clinical and host differences between infections with the two varieties of Cryptococcus neoformans","volume":"21","author":"Speed","year":"1995","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C27","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1128\/JCM.28.7.1642-1644.1990","article-title":"Natural habitat of Cryptococcus neoformans var. gattii","volume":"28","author":"Ellis","year":"1990","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180328143056_CIS529C28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/md.0b013e31803b52f5","article-title":"Cryptococcosis and idiopathic CD4 lymphopenia","volume":"86","author":"Zonios","year":"2007","journal-title":"Medicine"},{"key":"key\n\t\t\t\t20180328143056_CIS529C29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0163-4453(03)00083-5","article-title":"Sequential infection with Nocardia farcinica and Cryptococcus neoformans var. gattii in an immunocompetent host","volume":"47","author":"Hope","year":"2003","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20180328143056_CIS529C30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s100960050352","article-title":"Disseminated infection due to Nocardia transvalensis coincident with Cryptococcus neoformans variety gattii meningitis","volume":"18","author":"Dyer","year":"1999","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C31","first-page":"343","article-title":"Cryptococcal meningitis (C. neoforamns var. gattii) leading to blindness in previously-healthy melanesian adults in Papua New Guinea","volume":"87","author":"Lalloo","year":"1994","journal-title":". Q J Med"},{"key":"key\n\t\t\t\t20180328143056_CIS529C32","doi-asserted-by":"crossref","first-page":"c47","DOI":"10.1086\/313603","article-title":"Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. the NIAID mycoses study group and AIDS cooperative treatment groups","volume":"30","author":"Graybill","year":"2000","journal-title":"Clin. Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/518607","article-title":"Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-na\u00efve or antiretroviral-experienced patients treated with amphotericin B or fluconazole","volume":"45","author":"Bicanic","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328143056_CIS529C34","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1086\/604716","article-title":"Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients","volume":"49","author":"Bicanic","year":"2009","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/55\/6\/789\/17350376\/cis529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T07:32:21Z","timestamp":1594193541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/55\/6\/789\/344542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,5]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,5]]},"published-print":{"date-parts":[[2012,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cis529","relation":{},"ISSN":["1537-6591","1058-4838"],"issn-type":[{"value":"1537-6591","type":"electronic"},{"value":"1058-4838","type":"print"}],"subject":[],"published-other":{"date-parts":[[2012,9,15]]},"published":{"date-parts":[[2012,6,5]]}}}