{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:35:45Z","timestamp":1790379345426,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,15]]},"DOI":"10.1093\/cid\/ciu725","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T01:50:19Z","timestamp":1414115419000},"page":"1733-1740","source":"Crossref","is-referenced-by-count":150,"title":["A Breath Fungal Secondary Metabolite Signature to Diagnose Invasive Aspergillosis"],"prefix":"10.1093","volume":"59","author":[{"given":"Sophia","family":"Koo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horatio R.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. David","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preshious","family":"Rearden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Comolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey R.","family":"Baden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M.","family":"Marty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"key\n\t\t\t\t20170522092252_CIU725C1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ajh.21776","article-title":"Invasive fungal disease in patients treated for newly diagnosed acute leukemia","volume":"85","year":"2010","journal-title":"Am J Hematol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/651263","article-title":"Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database","volume":"50","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/CMR.18.1.44-69.2005","article-title":"Aspergillus infections in transplant recipients","volume":"18","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170522092252_CIU725C4","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1086\/651262","article-title":"Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)","volume":"50","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1086\/595846","article-title":"Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry","volume":"48","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/318483","article-title":"Aspergillosis case-fatality rate: systematic review of the literature","volume":"32","year":"2001","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C7","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1056\/NEJMra0808853","article-title":"Aspergillosis","volume":"360","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170522092252_CIU725C8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1086\/509917","article-title":"Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign","volume":"44","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C9","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1086\/323900","article-title":"The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis","volume":"33","year":"2001","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1473-3099(05)70238-3","article-title":"Laboratory diagnosis of invasive aspergillosis","volume":"5","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C11","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1086\/503427","article-title":"Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis","volume":"42","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C12","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1086\/647942","article-title":"Diagnostic performance of the (1\u21923)-beta-D-glucan assay for invasive fungal disease","volume":"49","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.diagmicrobio.2010.02.028","article-title":"Aspergillus DNA contamination in blood collection tubes","volume":"67","year":"2010","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1473-3099(09)70019-2","article-title":"Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis","volume":"9","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C15","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrmicro1286","article-title":"Fungal secondary metabolism\u2014from biochemistry to genomics","volume":"3","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11101-011-9216-2","article-title":"Volatile sesquiterpenes from fungi: what are they good for?","volume":"11","year":"2012","journal-title":"Phytochem Rev"},{"issue":"(suppl 1)","key":"key\n\t\t\t\t20170522092252_CIU725C17","first-page":"S53","article-title":"Metabolomics of Aspergillus fumigatus","year":"2009","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C18","doi-asserted-by":"crossref","first-page":"e1000154","DOI":"10.1371\/journal.ppat.1000154","article-title":"Sub-telomere directed gene expression during initiation of invasive aspergillosis","volume":"4","year":"2008","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170522092252_CIU725C19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nchembio.2007.5","article-title":"The function of terpene natural products in the natural world","volume":"3","year":"2007","journal-title":"Nat Chem Biol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1078\/1438-4639-00094","article-title":"Detection of microbial volatile organic compounds (MVOCs) produced by moulds on various materials","volume":"204","year":"2001","journal-title":"Int J Hyg Environ Health"},{"key":"key\n\t\t\t\t20170522092252_CIU725C21","doi-asserted-by":"crossref","first-page":"e828","DOI":"10.1111\/j.1439-0507.2011.02037.x","article-title":"Detection of characteristic metabolites of Aspergillus fumigatus and Candida species using ion mobility spectrometry\u2013metabolic profiling by volatile organic compounds","volume":"54","year":"2011","journal-title":"Mycoses"},{"key":"key\n\t\t\t\t20170522092252_CIU725C22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/15428110208984696","article-title":"Determination of unique microbial volatile organic compounds produced by five Aspergillus species commonly found in problem buildings","volume":"63","year":"2002","journal-title":"AIHA J (Fairfax, Va)"},{"key":"key\n\t\t\t\t20170522092252_CIU725C23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/13693780701753800","article-title":"Investigation into the production of 2-pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples","volume":"46","year":"2008","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C24","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1128\/JCM.01070-09","article-title":"Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network","volume":"47","year":"2009","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C25","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1128\/JCM.00854-09","article-title":"Patterns of susceptibility of Aspergillus isolates recovered from patients enrolled in the Transplant-Associated Infection Surveillance Network","volume":"47","year":"2009","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrmicro2916","article-title":"Regulation of fungal secondary metabolism","volume":"11","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0065-2660(08)60408-3","article-title":"The genetics of Aspergillus nidulans","volume":"5","year":"1953","journal-title":"Adv Genet"},{"key":"key\n\t\t\t\t20170522092252_CIU725C28","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"46","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C29","article-title":"gplots: various R programming tools for plotting data","year":"2009"},{"key":"key\n\t\t\t\t20170522092252_CIU725C30","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0895-4356(91)90128-V","article-title":"Likelihood ratios with confidence: sample size estimation for diagnostic test studies","volume":"44","year":"1991","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/CMR.00020-13","article-title":"Clinical application of volatile organic compound analysis for detecting infectious diseases","volume":"26","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170522092252_CIU725C32","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2174\/138920111795909050","article-title":"Volatile disease biomarkers in breath: a critique","volume":"12","year":"2011","journal-title":"Curr Pharm Biotechnol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C33","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.3109\/13693786.2010.508187","article-title":"Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus","volume":"49","year":"2011","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20170522092252_CIU725C34","first-page":"3","article-title":"Techniques in infectious diseases: identification of unique volatile compounds of Aspergillus fumigatus for potential diagnostic breath test by HS-SPME and GC-MS","volume":"2","year":"2013","journal-title":"J Immunol Tech Infect Dis"},{"key":"key\n\t\t\t\t20170522092252_CIU725C35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jnci\/dji008","article-title":"Signal in noise: evaluating reported reproducibility of serum proteomic tests for ovarian cancer","volume":"97","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t20170522092252_CIU725C36","doi-asserted-by":"crossref","first-page":"016002","DOI":"10.1088\/1752-7155\/6\/1\/016002","article-title":"Biomedically important pathogenic fungi detection with volatile biomarkers","volume":"6","year":"2012","journal-title":"J Breath Res"},{"key":"key\n\t\t\t\t20170522092252_CIU725C37","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1128\/EC.00074-14","article-title":"The volatome of Aspergillus fumigatus","volume":"13","year":"2014","journal-title":"Eukaryot Cell"},{"key":"key\n\t\t\t\t20170522092252_CIU725C38","first-page":"4625","article-title":"Isolation of b-trans-bergamotene from Aspergillus fumigatus, a fumagillin producing fungi","volume":"50","year":"1976","journal-title":"Tetrahedron Lett"},{"key":"key\n\t\t\t\t20170522092252_CIU725C39","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1021\/ja312503y","article-title":"The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of \u03b2-trans-bergamotene","volume":"135","year":"2013","journal-title":"J Am Chem Soc"},{"key":"key\n\t\t\t\t20170522092252_CIU725C40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.1141630","article-title":"Chemistry. Roots of biosynthetic diversity","volume":"316","year":"2007","journal-title":"Science"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T15:35:42Z","timestamp":1565969742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article-lookup\/doi\/10.1093\/cid\/ciu725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,10,22]]},"published-print":{"date-parts":[[2014,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciu725","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}