{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:51:24Z","timestamp":1790268684206,"version":"4.1.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacteriaceae present an ever-growing burden in the hospital and community settings, across all ages and demographics. Infections due to ESBL-containing pathogens continue to be associated with significant morbidity and mortality worldwide. With widespread empiric broad-spectrum \u03b2-lactam use creating selective pressure, and the resultant emergence of stable, rapidly proliferating ESBL-producing clones with continued horizontal gene transfer across genera, addressing this issue remains imperative. Although well characterized in adults, the epidemiology, risk factors, outcomes, therapies, and control measures for ESBL-producing bacteria are less appreciated in children. This analysis provides a brief summary of ESBL-producing Enterobacteriaceae in children, with a focus on recent clinical and molecular data regarding colonization and infection in nonoutbreak settings.<\/jats:p>","DOI":"10.1093\/cid\/civ020","type":"journal-article","created":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T04:29:06Z","timestamp":1421468946000},"page":"1389-1397","source":"Crossref","is-referenced-by-count":101,"title":["Extended-Spectrum \u03b2-Lactamase\u2013Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat"],"prefix":"10.1093","volume":"60","author":[{"given":"Paul J.","family":"Lukac","sequence":"first","affiliation":[{"name":"1 Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Louis Stokes Cleveland Department of Veterans Affairs Medical Center 3 Research Service ,"},{"name":"4 Department of Medicine"},{"name":"5 Department of Pharmacology"},{"name":"Case Western Reserve School of Medicine, Cleveland, Ohio 6 Department of Molecular Biology and Microbiology ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latania K.","family":"Logan","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics"},{"name":"Rush University Medical Center, Rush Medical College 2 Section of Pediatric Infectious Diseases , , Chicago , Illinois"},{"name":"Louis Stokes Cleveland Department of Veterans Affairs Medical Center 3 Research Service ,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"2024111411394471200_CIV020C1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/nyas.12023","article-title":"Proliferation and significance of clinically relevant beta-lactamases","volume":"1277","author":"Bush","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"2024111411394471200_CIV020C2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2024111411394471200_CIV020C3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: a clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"2024111411394471200_CIV020C4","article-title":"Beta-lactamases: ubiquitous and formidable","author":"Bush","year":"2014"},{"key":"2024111411394471200_CIV020C5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/jac\/dkm318","article-title":"Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis","volume":"60","author":"Schwaber","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"2024111411394471200_CIV020C6","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1128\/AAC.00143-10","article-title":"Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-\u03b2-lactamase production and inadequate initial antibiotic therapy","volume":"54","author":"Tumbarello","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2024111411394471200_CIV020C7","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/cid\/ciu069","article-title":"Treatment of multidrug-resistant gram-negative infections in children","volume":"58","author":"Hsu","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2024111411394471200_CIV020C8","article-title":"Performance standards for antimicrobial susceptibility testing: 20th informational supplement. 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