{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:51:31Z","timestamp":1791910291740,"version":"4.3.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,15]]},"DOI":"10.1093\/cid\/civ028","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T23:38:49Z","timestamp":1421797129000},"page":"e27-e35","source":"Crossref","is-referenced-by-count":74,"title":["Outcomes of Invasive Meningococcal Disease in Adults and Children in Canada Between 2002 and 2011: A Prospective Cohort Study"],"prefix":"10.1093","volume":"60","author":[{"given":"Manish","family":"Sadarangani","sequence":"first","affiliation":[{"name":"Vaccine Evaluation Center, Division of Infectious and Immunological Diseases, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, Canada"},{"name":"Department of Paediatrics, University of Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Scheifele","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, Division of Infectious and Immunological Diseases, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Halperin","sequence":"additional","affiliation":[{"name":"Canadian Center for Vaccinology, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Vaudry","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Stollery Children's Hospital and University of Alberta, Edmonton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Le Saux","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Children's Hospital of Eastern Ontario, Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Tsang","sequence":"additional","affiliation":[{"name":"Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, Division of Infectious and Immunological Diseases, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the investigators of the Canadian Immunization Monitoring Program, ACTive (IMPACT)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bridger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Top","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"D\u00e9ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Le Saux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ford-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Embree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Jadavji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. G.","family":"Vanderkooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Scheifele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sauv\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bettinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"issue":"suppl 2","key":"key\n\t\t\t\t20180328151824_CIV028C1","doi-asserted-by":"crossref","first-page":"B26","DOI":"10.1016\/j.vaccine.2011.12.032","article-title":"The changing and dynamic epidemiology of meningococcal disease","volume":"30","author":"Halperin","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180328151824_CIV028C2","volume-title":"Evaluation of a potential vaccine against hyperinvasive serogroup B Neisseria meningitidis by assessment of the effects of surface-expressed opacity-associated proteins on the immune system","author":"Sadarangani","year":"2011"},{"issue":"suppl 2","key":"key\n\t\t\t\t20180328151824_CIV028C3","doi-asserted-by":"crossref","first-page":"B3","DOI":"10.1016\/j.vaccine.2011.12.062","article-title":"Meningococcal disease: clinical presentation and sequelae","volume":"30","author":"Pace","year":"2012","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180328151824_CIV028C4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1473-3099(14)70756-X","article-title":"The case for vaccinating against meningitis B","volume":"14","author":"The Lancet Infectious Diseases","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180328151824_CIV028C5","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0140-6736(14)60226-9","article-title":"Group B meningococcal vaccine: recommendations for UK use","volume":"383","author":"Pollard","year":"2014","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328151824_CIV028C6","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/cid\/ciu597","article-title":"The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012","volume":"59","author":"Sadarangani","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328151824_CIV028C7","volume-title":"EU-IBIS Network. Invasive Neisseria meningitidis in Europe 2006","author":"Ramsay","year":"2007"},{"key":"key\n\t\t\t\t20180328151824_CIV028C8","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00006454-199611000-00009","article-title":"Pathophysiology, treatment and outcome of meningococcemia: a review and recent experience","volume":"15","author":"Kirsch","year":"1996","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180328151824_CIV028C9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/00365549609027149","article-title":"Clinical manifestations and course of meningococcal disease in 562 patients","volume":"28","author":"Schildkamp","year":"1996","journal-title":"Scand J Infect Dis"},{"key":"key\n\t\t\t\t20180328151824_CIV028C10","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1093\/cid\/cir500","article-title":"Comparative long-term adverse effects elicited by invasive group B and C meningococcal infections","volume":"53","author":"Gottfredsson","year":"2011","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328151824_CIV028C11","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJMoa040845","article-title":"Clinical features and prognostic factors in adults with bacterial meningitis","volume":"351","author":"van de Beek","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328151824_CIV028C12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/adc.85.1.6","article-title":"Neurodevelopmental outcome in meningococcal disease: a case-control study","volume":"85","author":"Fellick","year":"2001","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20180328151824_CIV028C13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00006454-199305000-00008","article-title":"Outcomes of bacterial meningitis in children: a meta-analysis","volume":"12","author":"Baraff","year":"1993","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180328151824_CIV028C14","first-page":"861","article-title":"Association of meningococcal serogroups with the course of disease in the Netherlands, 1959\u201383","volume":"65","author":"Spanjaard","year":"1987","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t20180328151824_CIV028C15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/adc.2007.131862","article-title":"Long-term skin scarring and orthopaedic sequelae in survivors of meningococcal septic shock","volume":"94","author":"Buysse","year":"2009","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20180328151824_CIV028C16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/01.CCM.0000299740.65484.CA","article-title":"Surviving meningococcal septic shock: health consequences and quality of life in children and their parents up to 2 years after pediatric intensive care unit discharge","volume":"36","author":"Buysse","year":"2008","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t20180328151824_CIV028C17","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/cc9087","article-title":"Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life","volume":"14","author":"Buysse","year":"2010","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t20180328151824_CIV028C18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/INF.0000000000000282","article-title":"The clinical features and long term sequelae of invasive meningococcal disease in children","volume":"33","author":"Stein-Zamir","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180328151824_CIV028C19","doi-asserted-by":"crossref","first-page":"e502","DOI":"10.1542\/peds.2008-0581","article-title":"Outcomes of meningococcal disease in adolescence: prospective, matched-cohort study","volume":"123","author":"Borg","year":"2009","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180328151824_CIV028C20","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s00134-002-1237-2","article-title":"Psychiatric adjustment following meningococcal disease treated on a PICU","volume":"28","author":"Judge","year":"2002","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t20180328151824_CIV028C21","first-page":"3","article-title":"Late sequelae after meningococcal disease. A controlled study in young men","volume":"7","author":"Sander","year":"1984","journal-title":"NIPH Ann"},{"key":"key\n\t\t\t\t20180328151824_CIV028C22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/pubmed\/fdt004","article-title":"Mortality from meningococcal disease by day of the week: English national linked database study","volume":"35","author":"Goldacre","year":"2013","journal-title":"J Public Health (Oxf)"},{"key":"key\n\t\t\t\t20180328151824_CIV028C23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/MD.0b013e318180a6b4","article-title":"Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study","volume":"87","author":"Heckenberg","year":"2008","journal-title":"Medicine (Baltimore)"},{"key":"key\n\t\t\t\t20180328151824_CIV028C24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0022-3476(66)80250-0","article-title":"Factors in the prognosis of meningococcal infection. Review of 63 cases with emphasis on recognition and management of the severely ill patient","volume":"68","author":"Stiehm","year":"1966","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t20180328151824_CIV028C25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/adc.85.5.386","article-title":"Reduction in case fatality rate from meningococcal disease associated with improved healthcare delivery","volume":"85","author":"Booy","year":"2001","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20180328151824_CIV028C26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/adc.85.5.382","article-title":"Mortality in severe meningococcal disease","volume":"85","author":"Thorburn","year":"2001","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t20180328151824_CIV028C27","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/cc12609","article-title":"A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis","volume":"17","author":"Couto-Alves","year":"2013","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t20180328151824_CIV028C28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF01712247","article-title":"The outcome of children admitted to intensive care with meningococcal septicaemia","volume":"22","author":"Mok","year":"1996","journal-title":"Intensive Care Med"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/60\/8\/e27\/16787311\/civ028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T17:46:47Z","timestamp":1522259207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/60\/8\/e27\/2462960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,20]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,1,20]]},"published-print":{"date-parts":[[2015,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/civ028","relation":{},"ISSN":["1537-6591","1058-4838"],"issn-type":[{"value":"1537-6591","type":"electronic"},{"value":"1058-4838","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,4,15]]},"published":{"date-parts":[[2015,1,20]]}}}