{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:13:59Z","timestamp":1791954839321,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background. \u2003Cryptococcus gattii (Cg) infection emerged in British Columbia in 1999. A longitudinal, clinical description of patients has not been reported.<\/jats:p>\n               <jats:p>Methods. \u2003Medical records were reviewed for Cg patients identified through surveillance (1999\u20132007). Risk factors for Cg mortality were explored using multivariate Cox regression; longitudinal patterns in serum cryptococcal antigen (SCrAg) titers and the probability of chest cryptococcomas over time were estimated using cubic B-splines in mixed-effects regression models.<\/jats:p>\n               <jats:p>Results. \u2003Among 152 patients, 111 (73.0%) were culture confirmed. Isolated lung infection was present in 105 (69.1%) patients; 47 (30.9%) had central nervous system infection, with or without lung involvement. Malignancy was the provisional diagnosis in 64 (42.1%) patients. Underlying diseases were present in 91 (59.9%) patients; 23 (15.1%) were immunocompromised, and 23 (15.1%) had asymptomatic disease. There were only 2 (1.8%) culture positive relapses, both within 12 months of follow-up. The estimated median time to resolution of lung cryptococcomas and decline in SCrAg titer to &amp;lt;1:8 was 2.8 and 2.9 years, respectively. Cg-related and all-cause mortality among culture-confirmed cases at 12 months\u2019 follow-up was 23.3% and 27.2%, respectively. Cg-related mortality was associated with age &amp;gt;50 years (hazard ratio [HR], 15.6; 95% confidence interval [CI], 1.9\u2013130.5) and immunocompromise (HR, 5.8; CI, 1.5\u201321.6). All Cg-related mortality occurred among culture-positive cases within 1 year of diagnosis.<\/jats:p>\n               <jats:p>Conclusions. \u2003Cryptococcomas and serum antigenemia were slow to resolve. However, late onset of failed therapy or relapse was uncommon, suggesting that delayed resolution of these findings does not require prolongation of treatment beyond that recommended by guidelines.<\/jats:p>","DOI":"10.1093\/cid\/civ041","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T03:49:39Z","timestamp":1422503379000},"page":"1368-1376","source":"Crossref","is-referenced-by-count":41,"title":["Longitudinal Clinical Findings and Outcome Among Patients With <i>Cryptococcus gattii<\/i> Infection in British Columbia"],"prefix":"10.1093","volume":"60","author":[{"given":"Peter","family":"Phillips","sequence":"first","affiliation":[{"name":"St Paul's Hospital 1 Division of Infectious Diseases ,"},{"name":"University of British Columbia 2"},{"name":"Vancouver General Hospital 3 Division of Infectious Diseases 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for Disease Control 4"},{"name":"University of British Columbia 5 Division of Respirology , , Vancouver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bowie","sequence":"additional","affiliation":[{"name":"University of British Columbia 2"},{"name":"Vancouver General Hospital 3 Division of Infectious Diseases ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Steiner","sequence":"additional","affiliation":[{"name":"University of British Columbia 2"},{"name":"Vancouver General Hospital 3 Division of Infectious Diseases ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hoang","sequence":"additional","affiliation":[{"name":"University of British Columbia 2"},{"name":"British Columbia Centre for Disease Control 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Morshed","sequence":"additional","affiliation":[{"name":"University of British Columbia 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General Hospital 8 Department of Microbiology ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C.","family":"Kibsey","sequence":"additional","affiliation":[{"name":"University of British Columbia 2"},{"name":"9 Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Connolly","sequence":"additional","affiliation":[{"name":"University of British Columbia 2"},{"name":"Royal Jubilee Hospital 10 Division of Respirology , , Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazdan","family":"Mirzanejad","sequence":"additional","affiliation":[{"name":"University of British Columbia 2"},{"name":"Surrey Memorial Hospital 11 Division of Infectious Diseases , , British Columbia ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darby","family":"Thompson","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control 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