{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:48:56Z","timestamp":1790376536546,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Infect Dis."],"published-print":{"date-parts":[[2016,5,15]]},"DOI":"10.1093\/cid\/ciw076","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T01:54:07Z","timestamp":1455587647000},"page":"1297-1303","source":"Crossref","is-referenced-by-count":82,"title":["Determinants of a Low CD4\/CD8 Ratio in HIV-1\u2013Infected Individuals Despite Long-term Viral Suppression"],"prefix":"10.1093","volume":"62","author":[{"given":"Fabienne","family":"Caby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Guihot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidonie","family":"Lambert-Niclot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Guiguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boutolleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Agher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Valantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Tubiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Calvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Genevi\u00e8ve","family":"Marcelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guislaine","family":"Carcelain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Autran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Costagliola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Katlama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,14]]},"reference":[{"key":"2016042608122228000_62.10.1297.1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000815"},{"key":"2016042608122228000_62.10.1297.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.12.002"},{"key":"2016042608122228000_62.10.1297.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ327"},{"key":"2016042608122228000_62.10.1297.4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331306"},{"key":"2016042608122228000_62.10.1297.5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000844"},{"key":"2016042608122228000_62.10.1297.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000437171.00504.41"},{"key":"2016042608122228000_62.10.1297.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004078"},{"key":"2016042608122228000_62.10.1297.8","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00006-5"},{"key":"2016042608122228000_62.10.1297.9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077665"},{"key":"2016042608122228000_62.10.1297.10","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835faa72"},{"key":"2016042608122228000_62.10.1297.11","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000286"},{"key":"2016042608122228000_62.10.1297.12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302596"},{"key":"2016042608122228000_62.10.1297.13","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2093"},{"key":"2016042608122228000_62.10.1297.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(00)00210-4"},{"key":"2016042608122228000_62.10.1297.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00212-1"},{"key":"2016042608122228000_62.10.1297.16","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000223028.55080.9d"},{"key":"2016042608122228000_62.10.1297.17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/135965350901400311","article-title":"CD4+ T-cell percentage is an independent predictor of clinical progression in AIDS-free antiretroviral-naive patients with CD4+ T-cell counts >200 cells\/mm3","volume":"14","author":"Guiguet","year":"2009","journal-title":"Antivir Ther"},{"key":"2016042608122228000_62.10.1297.18","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328333ea9e"},{"issue":"4 suppl 3","key":"2016042608122228000_62.10.1297.19","doi-asserted-by":"crossref","first-page":"19723","DOI":"10.7448\/IAS.17.4.19723","article-title":"The CD4:CD8 ratio is associated with IMT progression in HIV-infected patients on antiretroviral treatment","volume":"17","author":"Bernal","year":"2014","journal-title":"J Int AIDS Soc"},{"key":"2016042608122228000_62.10.1297.20","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12081"},{"key":"2016042608122228000_62.10.1297.21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085798"},{"key":"2016042608122228000_62.10.1297.22","unstructured":"May M , Trickey A , Costagliola D et al . Association of CD4:CD8 with cause-specific mortality in patients on long term ART. In: 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, WA, 23\u201326 February 2015."},{"key":"2016042608122228000_62.10.1297.23","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-008-9138-6"},{"key":"2016042608122228000_62.10.1297.24","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9400-3"},{"key":"2016042608122228000_62.10.1297.25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020713"},{"key":"2016042608122228000_62.10.1297.26","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181945ed4"},{"issue":"4 suppl 3","key":"2016042608122228000_62.10.1297.27","doi-asserted-by":"crossref","first-page":"19481","DOI":"10.7448\/IAS.17.4.19481","article-title":"CD4+ cell count recovery in naive patients initiating cART, who achieved and maintained plasma HIV-RNA suppression","volume":"17","author":"Costagliola","year":"2014","journal-title":"J Int AIDS Soc"},{"key":"2016042608122228000_62.10.1297.28","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833556f3"},{"key":"2016042608122228000_62.10.1297.29","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu834"},{"key":"2016042608122228000_62.10.1297.30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/QAD.0000000000000571","article-title":"Influence of lifelong cumulative HIV viremia on long-term recovery of CD4+ cell count and CD4+\/CD8+ ratio among patients on combination antiretroviral therapy","volume":"29","author":"Seng","year":"2015","journal-title":"AIDS"},{"key":"2016042608122228000_62.10.1297.31","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000405"},{"key":"2016042608122228000_62.10.1297.32","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ840"},{"key":"2016042608122228000_62.10.1297.33","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis620"},{"key":"2016042608122228000_62.10.1297.34","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu417"},{"key":"2016042608122228000_62.10.1297.35","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3280108704"},{"key":"2016042608122228000_62.10.1297.36","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis288"},{"key":"2016042608122228000_62.10.1297.37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046073"},{"key":"2016042608122228000_62.10.1297.38","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir060"},{"key":"2016042608122228000_62.10.1297.39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309533"},{"key":"2016042608122228000_62.10.1297.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097698"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/62\/10\/1297\/16787889\/ciw076.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T06:59:36Z","timestamp":1654325976000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article-lookup\/doi\/10.1093\/cid\/ciw076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,14]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,4,26]]},"published-print":{"date-parts":[[2016,5,15]]}},"alternative-id":["10.1093\/cid\/ciw076"],"URL":"https:\/\/doi.org\/10.1093\/cid\/ciw076","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,14]]}}}