{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:37:56Z","timestamp":1790386676589,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CLINID"],"published-print":{"date-parts":[[2017,1,15]]},"DOI":"10.1093\/cid\/ciw711","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T11:06:59Z","timestamp":1476788819000},"page":"152-158","source":"Crossref","is-referenced-by-count":32,"title":["Thymic Function Impacts the Peripheral CD4\/CD8 Ratio of HIV-Infected Subjects"],"prefix":"10.1093","volume":"64","author":[{"given":"I.","family":"Rosado-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Herrero-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Genebat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ruiz-Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda M.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"2017011006050701000_64.2.152.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250472097"},{"key":"2017011006050701000_64.2.152.2","doi-asserted-by":"crossref","first-page":"e94018","DOI":"10.1371\/journal.pone.0094018","article-title":"Delay in cART initiation results in persistent immune dysregulation and poor recovery of T cell phenotype despite a decade of successful HIV suppression","volume":"9","author":"Ndumbi","year":"2014","journal-title":"PLoS One"},{"key":"2017011006050701000_64.2.152.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ809"},{"key":"2017011006050701000_64.2.152.4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw293"},{"key":"2017011006050701000_64.2.152.5","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12081"},{"key":"2017011006050701000_64.2.152.6","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328333ea9e"},{"key":"2017011006050701000_64.2.152.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085798"},{"key":"2017011006050701000_64.2.152.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004078"},{"key":"2017011006050701000_64.2.152.9","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001005"},{"key":"2017011006050701000_64.2.152.10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302596"},{"key":"2017011006050701000_64.2.152.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.09.013"},{"key":"2017011006050701000_64.2.152.12","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835faa72"},{"key":"2017011006050701000_64.2.152.13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ840"},{"key":"2017011006050701000_64.2.152.14","doi-asserted-by":"crossref","unstructured":"Barrett L Fudge NJ Heath JJ Grant MD . Cytomegalovirus immunity and exhaustive CD8+ T cell proliferation in treated human immunodeficiency virus infection. Clin Infect Dis 2016; DOI: 10.1093\/cid\/ciw148.","DOI":"10.1093\/cid\/ciw148"},{"key":"2017011006050701000_64.2.152.15","doi-asserted-by":"crossref","unstructured":"Caby F Guihot A Lambert-Niclot S . Determinants of a low CD4\/CD8 ratio in HIV-1\u2013infected individuals despite long-term viral suppression. Clin Infect Dis 2016; DOI: 10.1093\/cid\/ciw076.","DOI":"10.1093\/cid\/ciw076"},{"key":"2017011006050701000_64.2.152.16","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.5.556"},{"key":"2017011006050701000_64.2.152.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2006.04.003"},{"key":"2017011006050701000_64.2.152.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-008-9084-x"},{"key":"2017011006050701000_64.2.152.19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3702"},{"key":"2017011006050701000_64.2.152.20","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-011-9341-2"},{"key":"2017011006050701000_64.2.152.21","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.269"},{"key":"2017011006050701000_64.2.152.22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01152.x"},{"key":"2017011006050701000_64.2.152.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077665"},{"key":"2017011006050701000_64.2.152.24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/135965350200700304","article-title":"Baseline thymic volume is a predictor for CD4 T cell repopulation in adult HIV-infected patients under highly active antiretroviral therapy","volume":"7","author":"de la Rosa","year":"2002","journal-title":"Antivir Ther"},{"key":"2017011006050701000_64.2.152.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02474.x"},{"key":"2017011006050701000_64.2.152.26","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000219778.12551.c0"},{"key":"2017011006050701000_64.2.152.27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/QAI.0000000000000801","article-title":"Thymic function is most severely impaired in chronic HIV-1 infection, but individuals with faster disease progression during early HIV-1 infection expressed lower levels of RTEs","volume":"70","author":"He","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2017011006050701000_64.2.152.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2012.12.025"},{"key":"2017011006050701000_64.2.152.29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201235"},{"key":"2017011006050701000_64.2.152.30","doi-asserted-by":"crossref","first-page":"20697","DOI":"10.7448\/IAS.19.1.20697","article-title":"Elevation and persistence of CD8 T cells in HIV infection: the Achilles heel in the ART era","volume":"19","author":"Cao","year":"2016","journal-title":"J Int AIDS Soc"},{"key":"2017011006050701000_64.2.152.31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002000"},{"key":"2017011006050701000_64.2.152.32","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2018"},{"key":"2017011006050701000_64.2.152.33","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-008-9084-x"},{"key":"2017011006050701000_64.2.152.34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2834"},{"key":"2017011006050701000_64.2.152.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.10.013"},{"key":"2017011006050701000_64.2.152.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.11.007"},{"key":"2017011006050701000_64.2.152.37","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283519b22"},{"key":"2017011006050701000_64.2.152.38","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/19485565.2016.1172199","article-title":"Population distributions of thymic function in adults: variation by sociodemographic characteristics and health status","volume":"62","author":"Feinstein","year":"2016","journal-title":"Biodemography Soc Biol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/64\/2\/152\/13803513\/ciw711.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T16:15:19Z","timestamp":1657469719000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article-lookup\/doi\/10.1093\/cid\/ciw711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,4]]},"published-print":{"date-parts":[[2017,1,15]]}},"alternative-id":["10.1093\/cid\/ciw711"],"URL":"https:\/\/doi.org\/10.1093\/cid\/ciw711","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}