{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:02:14Z","timestamp":1781845334367,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tuberculous meningitis (TBM) remains a major cause of death and disability in tuberculosis-endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results. We propose standardized methods for the conduct of TBM clinical research that were drafted at an international tuberculous meningitis research meeting organized by the Oxford University Clinical Research Unit in Vietnam. We propose a core dataset including demographic and clinical information to be collected at study enrollment, important aspects related to patient management and monitoring, and standardized reporting of patient outcomes. The criteria proposed for the conduct of observational and intervention TBM studies should improve the quality of future research outputs, can facilitate multicenter studies and meta-analyses of pooled data, and could provide the foundation for a global TBM data repository.<\/jats:p>","DOI":"10.1093\/cid\/ciw757","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T12:05:40Z","timestamp":1478779540000},"page":"501-509","source":"Crossref","is-referenced-by-count":42,"title":["Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies"],"prefix":"10.1093","volume":"64","author":[{"given":"Ben J.","family":"Marais","sequence":"first","affiliation":[{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity and the Children\u2019s Hospital at Westmead, University of Sydney 1 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna D.","family":"Heemskerk","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit 2 , Ho Chi Minh City ,","place":["Vietnam"]},{"name":"Nuffield Department of Medicine, University of Oxford 3 ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzaan S.","family":"Marais","sequence":"additional","affiliation":[{"name":"Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town 4"},{"name":"Department of Neurology, Inkosi Albert Luthuli Central Hospital 5 , Durban ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center 6 , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Rohlwink","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Cape Town 7 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"Caws","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine 8 , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Meintjes","sequence":"additional","affiliation":[{"name":"Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha K.","family":"Misra","sequence":"additional","affiliation":[{"name":"Sanjay Ghandi Postgraduate Institute of Medical Sciences 9 , Lucknow ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen T. 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