{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:36:47Z","timestamp":1783525007835,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background.<\/jats:title>\n                  <jats:p>The liver fluke Opisthorchis viverrini, highly prevalent in Southeast Asia, is an important public health burden, including a risk factor for developing an aggressive bile duct cancer, cholangiocarcinoma, in chronically infected patients. Praziquantel, administered at a single 40 mg\/kg dose in preventive chemotherapy programs and 3 \u00d7 25 mg\/kg for individual treatment, is the drug of choice, yet information on the nature of the dose-response relationship is lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods.<\/jats:title>\n                  <jats:p>We performed a randomized, parallel, single-blind dose-ranging phase 2 trial in the Lao People\u2019s Democratic Republic in O. viverrini\u2013infected adults. Patients were randomly assigned to 30 mg\/kg, 40 mg\/kg, 50 mg\/kg, or 3 \u00d7 25 mg\/kg praziquantel or placebo. Adverse events were recorded at baseline, 3 hours, and 24 hours posttreatment. Cure rates (CRs) and egg reduction rates (ERRs) were estimated 3 weeks after drug administration using available case analysis. Dose-response curves were predicted using Emax models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>Two-hundred seventeen O. viverrini\u2013infected patients were assigned to the 5 treatment arms. The majority (94.3%) of patients harbored light infections. The Emax model predicted a high efficacy among the observed dose range. We observed CRs ranging from 92.7% to 95.5% and ERRs &amp;gt;99.5% for all praziquantel treatment groups. Adverse events were mild but higher in the standard treatment group (3 \u00d7 25 mg\/kg) than in the single-dose treatment arms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions.<\/jats:title>\n                  <jats:p>Single-dose praziquantel appears to be as efficacious as the standard 3 \u00d7 25 mg\/kg regimen for the treatment of O. viverrini infections, while presenting fewer adverse events. Further studies are necessary in moderate and heavy O. viverrini infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration.<\/jats:title>\n                  <jats:p>Randomized Controlled Trials (ISRCTN77186750).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciw785","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T12:07:16Z","timestamp":1479557236000},"page":"451-458","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy and Safety of Praziquantel Against Light Infections of <i>Opisthorchis viverrini<\/i>: A Randomized Parallel Single-Blind Dose-Ranging Trial"],"prefix":"10.1093","volume":"64","author":[{"given":"Somphou","family":"Sayasone","sequence":"first","affiliation":[{"name":"National Institute of Public Health, Ministry of Health 1 , Vientiane ,","place":["Lao People\u2019s Democratic Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Meister","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute 2 , Basel"},{"name":"University of Basel 3 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine 4 , Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Odermatt","sequence":"additional","affiliation":[{"name":"University of Basel 3 ,","place":["Switzerland"]},{"name":"Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute 5 , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youthanavanh","family":"Vonghachack","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ministry of Health 6 , Vientiane ,","place":["Lao People\u2019s Democratic Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syda","family":"Xayavong","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, Ministry of Health 1 , Vientiane ,","place":["Lao People\u2019s Democratic Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanpaseuth","family":"Senggnam","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, Ministry of Health 1 , Vientiane ,","place":["Lao People\u2019s Democratic Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khampheng","family":"Phongluxa","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, Ministry of Health 1 , Vientiane ,","place":["Lao People\u2019s Democratic Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hattendorf","sequence":"additional","affiliation":[{"name":"University of Basel 3 ,","place":["Switzerland"]},{"name":"Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute 5 , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac I.","family":"Bogoch","sequence":"additional","affiliation":[{"name":"Divisions of General Internal Medicine and Infectious Diseases, University Health Network 7"},{"name":"Department of Medicine, University of Toronto 8 , Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute 2 , Basel"},{"name":"University of Basel 3 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"2024111411402096300_CIT0001","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1473-3099(11)70294-8","article-title":"Global burden of human food-borne trematodiasis: a systematic review and meta-analysis","volume":"12","author":"F\u00fcrst","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"2024111411402096300_CIT0002","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1128\/CMR.00012-09","article-title":"Food-borne trematodiases","volume":"22","author":"Keiser","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"2024111411402096300_CIT0003","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.actatropica.2003.02.001","article-title":"Epidemiology of Opisthorchis viverrini","volume":"88","author":"Sithithaworn","year":"2003","journal-title":"Acta Trop"},{"key":"2024111411402096300_CIT0004","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0065-308X(10)72011-X","article-title":"Food-borne trematodiases in Southeast Asia epidemiology, pathology, clinical manifestation and control","volume":"72","author":"Sripa","year":"2010","journal-title":"Adv Parasitol"},{"key":"2024111411402096300_CIT0005","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.actatropica.2013.03.016","article-title":"Raw fish consumption in liver fluke endemic areas in rural southern Laos","volume":"127","author":"Xayaseng","year":"2013","journal-title":"Acta Trop"},{"key":"2024111411402096300_CIT0006","doi-asserted-by":"crossref","first-page":"S158","DOI":"10.1016\/j.actatropica.2010.07.006","article-title":"Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos","volume":"120","author":"Sripa","year":"2011","journal-title":"Acta Trop"},{"key":"2024111411402096300_CIT0007","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.pt.2012.07.006","article-title":"The tumorigenic liver fluke Opisthorchis viverrini\u2013multiple pathways to cancer","volume":"28","author":"Sripa","year":"2012","journal-title":"Trends Parasitol"},{"key":"2024111411402096300_CIT0008","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.pt.2008.08.011","article-title":"Opisthorchis viverrini: an underestimated parasite in world health","volume":"24","author":"Andrews","year":"2008","journal-title":"Trends Parasitol"},{"key":"2024111411402096300_CIT0009","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.actatropica.2003.03.001","article-title":"Clinical manifestation of opisthorchiasis and treatment","volume":"88","author":"Mairiang","year":"2003","journal-title":"Acta Trop"},{"key":"2024111411402096300_CIT0010","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00436-002-0751-z","article-title":"Praziquantel","volume":"90","author":"Cioli","year":"2003","journal-title":"Parasitol Res"},{"key":"2024111411402096300_CIT0011","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/QCO.0b013e32833de06a","article-title":"Update on the diagnosis and treatment of food-borne trematode infections","volume":"23","author":"Keiser","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"2024111411402096300_CIT0012","volume-title":"Control of food-borne trematode infections. WHO technical report series 849","author":"World Health Organization","year":"1995"},{"key":"2024111411402096300_CIT0013","volume-title":"Diagnosis and treatment in district hospitals: a diagnosis and treatment guideline for the district hospital in Lao PDR","author":"Lao Ministry of Health","year":"2004"},{"key":"2024111411402096300_CIT0014","first-page":"528","article-title":"Studies on the chemotherapy of human opisthorchiasis in Thailand: I. Clinical trial of praziquantel","volume":"11","author":"Bunnag","year":"1980","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2024111411402096300_CIT0015","first-page":"413","article-title":"Studies on the chemotherapy of human opisthorchiasis: III. Minimum effective dose of praziquantel","volume":"12","author":"Bunnag","year":"1981","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2024111411402096300_CIT0016","first-page":"1173","article-title":"Opisthorchis viverrini: clinical experience with praziquantel in hospital for tropical diseases","volume":"34","author":"Bunnag","year":"1984","journal-title":"Arzneimittelforschung"},{"key":"2024111411402096300_CIT0017","doi-asserted-by":"crossref","first-page":"e1726","DOI":"10.1371\/journal.pntd.0001726","article-title":"Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial","volume":"6","author":"Lovis","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"2024111411402096300_CIT0018","doi-asserted-by":"crossref","first-page":"e1481","DOI":"10.1371\/journal.pntd.0001481","article-title":"Spatial distribution of, and risk factors for, Opisthorchis viverrini infection in southern Lao PDR","volume":"6","author":"Forrer","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"2024111411402096300_CIT0019","doi-asserted-by":"crossref","first-page":"e1037","DOI":"10.1371\/journal.pntd.0001037","article-title":"Helminth and intestinal protozoa infections, multiparasitism and risk factors in Champasack province, Lao People\u2019s Democratic Republic","volume":"5","author":"Sayasone","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"2024111411402096300_CIT0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0031182000062600","article-title":"Opisthorchis viverrini: relationships between egg counts, worms recovered and antibody levels within an endemic community in northeast Thailand","volume":"102","author":"Elkins","year":"1991","journal-title":"Parasitology"},{"key":"2024111411402096300_CIT0021","first-page":"1473","article-title":"SAF\u2013an alternative fixation solution for parasitological stool specimens [in German]","volume":"120","author":"Marti","year":"1990","journal-title":"Schweiz Med Wochenschr"},{"key":"2024111411402096300_CIT0022","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.trstmh.2008.10.011","article-title":"Diversity of human intestinal helminthiasis in Lao PDR","volume":"103","author":"Sayasone","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2024111411402096300_CIT0023","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1128\/JCM.02011-08","article-title":"PCR Diagnosis of Opisthorchis viverrini and Haplorchis taichui infections in a Lao community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys","volume":"47","author":"Lovis","year":"2009","journal-title":"J Clin Microbiol"},{"key":"2024111411402096300_CIT0024","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S1473-3099(16)30198-0","article-title":"Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials","volume":"16","author":"Sayasone","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2024111411402096300_CIT0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1473-3099(15)00271-6","article-title":"Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study","volume":"16","author":"Moser","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2024111411402096300_CIT0026","first-page":"451","article-title":"Relationship between prevalence and intensity of Opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in north-east Thailand","volume":"62","author":"Upatham","year":"1984","journal-title":"Bull World Health Organ"},{"key":"2024111411402096300_CIT0027","volume-title":"R package DoseFinding: planning and analyzing dose finding experiments v.0.9\u201315","author":"Bornkamp"},{"key":"2024111411402096300_CIT0028","volume-title":"R package Tweedie: Tweedie exponential family models v.2.2.1","author":"Dunn"},{"key":"2024111411402096300_CIT0029","volume-title":"R package statmod: statistical modeling v.1.4.25","author":"Smyth"},{"key":"2024111411402096300_CIT0030","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1517\/13543784.14.12.1513","article-title":"Triclabendazole for the treatment of fascioliasis and paragonimiasis","volume":"14","author":"Keiser","year":"2005","journal-title":"Expert Opin Investig Drugs"},{"key":"2024111411402096300_CIT0031","volume-title":"Fact sheet: foodborne trematodiases","author":"World Health Organization"},{"key":"2024111411402096300_CIT0032","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.trstmh.2008.03.010","article-title":"Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe","volume":"102","author":"Midzi","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2024111411402096300_CIT0033","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1365-3156.2000.00646.x","article-title":"Efficacy of praziquantel against Schistosoma mansoni with particular consideration for intensity of infection","volume":"5","author":"Utzinger","year":"2000","journal-title":"Trop Med Int Health"},{"key":"2024111411402096300_CIT0034","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0035-9203(90)90333-A","article-title":"Pharmacokinetics of praziquantel in healthy volunteers and patients with schistosomiasis","volume":"84","author":"Mandour","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2024111411402096300_CIT0035","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1128\/AAC.44.10.2903-2904.2000","article-title":"Bioavailability of praziquantel increases with concomitant administration of food","volume":"44","author":"Castro","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"2024111411402096300_CIT0036","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/infdis\/152.3.637","article-title":"Praziquantel for the treatment of Clonorchis\/Opisthorchis infections: report of a double-blind, placebo-controlled trial","volume":"152","author":"Jong","year":"1985","journal-title":"J Infect Dis"},{"key":"2024111411402096300_CIT0037","first-page":"717","article-title":"Pharmacokinetics of praziquantel in patients with opisthorchiasis","volume":"24","author":"Na Bangchang","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2024111411402096300_CIT0038","first-page":"246","article-title":"Treatment of Opisthorchis viverrini and intestinal fluke infections with praziquantel","volume":"29","author":"Pungpak","year":"1998","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2024111411402096300_CIT0039","doi-asserted-by":"crossref","first-page":"809","DOI":"10.4269\/ajtmh.1994.51.809","article-title":"Clinical and pharmacokinetic study of praziquantel in Egyptian schistosomiasis patients with and without liver cell failure","volume":"51","author":"el Guiniady","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"2024111411402096300_CIT0040","doi-asserted-by":"crossref","first-page":"e1165","DOI":"10.1371\/journal.pntd.0001165","article-title":"A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg\/kg vs. 60 mg\/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil","volume":"5","author":"Olliaro","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"2024111411402096300_CIT0041","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0020-7519(01)00368-X","article-title":"Adverse effects of praziquantel treatment of Schistosoma japonicum infection: involvement of host anaphylactic reactions induced by parasite antigen release","volume":"32","author":"Matsumoto","year":"2002","journal-title":"Int J Parasitol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/64\/4\/451\/13803955\/ciw785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/64\/4\/451\/13803955\/ciw785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:50:16Z","timestamp":1731585016000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/64\/4\/451\/2623956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,12,1]]},"published-print":{"date-parts":[[2017,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciw785","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2,15]]},"published":{"date-parts":[[2016,12,1]]}}}