{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:21:23Z","timestamp":1792736483475,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.<\/jats:p>","DOI":"10.1093\/cid\/ciw864","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T04:06:32Z","timestamp":1482379592000},"page":"1268-1270","source":"Crossref","is-referenced-by-count":42,"title":["Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of <i>Neisseria gonorrhoeae<\/i> in a Large Health System"],"prefix":"10.1093","volume":"64","author":[{"given":"Lao-Tzu","family":"Allan-Blitz","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine 1 ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romney M.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, David Geffen School of Medicine 2 , and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peera","family":"Hemarajata","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, David Geffen School of Medicine 2 , and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashima","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Fielding School of Public Health, University of California, Los Angeles (UCLA) 3 ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Pandori","sequence":"additional","affiliation":[{"name":"Alameda County Department of Public Health 4 , Oakland, California ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Siedner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School and Massachusetts General Hospital 5 , Boston ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Klausner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine 6 , David Geffen School of Medicine, and"},{"name":"Department of Epidemiology, Fielding School of Public Health, UCLA 7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"2024111411403325900_CIT0001","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/CMR.00010-14","article-title":"Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future","volume":"27","author":"Unemo","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2024111411403325900_CIT0002","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"P T"},{"key":"2024111411403325900_CIT0003","volume-title":"Antibiotic resistance threats in the United States, 2013","author":"Centers for Disease Control and Prevention","year":"2013"},{"key":"2024111411403325900_CIT0004","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1128\/JCM.01909-06","article-title":"Real-time PCR assay for detection of quinolone-resistant Neisseria gonorrhoeae in urine samples","volume":"45","author":"Siedner","year":"2007","journal-title":"J Clin Microbiol"},{"key":"2024111411403325900_CIT0005","first-page":"30","article-title":"Neisseria gonorrhoeae susceptibility to ciprofloxacin","volume":"48","author":"Allan-Blitz","year":"2016","journal-title":"MLO Med Lab Obs"},{"key":"2024111411403325900_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6507a1","article-title":"Neisseria gonorrhoeae antimicrobial susceptibility surveillance\u2014the Gonococcal Isolate Surveillance Project, 27 sites, United States, 2014","volume":"65","author":"Kirkcaldy","year":"2016","journal-title":"MMWR Surveill Summ"},{"key":"2024111411403325900_CIT0007","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/jac\/dku396","article-title":"Stemming the tide of drug-resistant Neisseria gonorrhoeae: the need for an individualized approach to treatment","volume":"70","author":"Buono","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2024111411403325900_CIT0008","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1128\/JCM.03032-15","article-title":"Performance and verification of a real-time PCR assay targeting the gyrA gene for prediction of ciprofloxacin resistance in Neisseria gonorrhoeae","volume":"54","author":"Hemarajata","year":"2016","journal-title":"J Clin Microbiol"},{"key":"2024111411403325900_CIT0009","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1093\/clinids\/20.Supplement_1.S47","article-title":"Drugs of choice for the treatment of uncomplicated gonococcal infections","volume":"20(","author":"Moran","year":"1995","journal-title":"Clin Infect Dis"},{"key":"2024111411403325900_CIT0010","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2217\/fmb.12.117","article-title":"Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea","volume":"7","author":"Unemo","year":"2012","journal-title":"Future Microbiol"},{"key":"2024111411403325900_CIT0011","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/cid\/civ447","article-title":"Randomized trial of rapid multiplex polymerase chain reaction-based blood culture identification and susceptibility testing","volume":"61","author":"Banerjee","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2024111411403325900_CIT0012","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00007435-199411000-00009","article-title":"Single-dose ciprofloxacin for the treatment of uncomplicated gonorrhea: a worldwide summary","volume":"21","author":"Echols","year":"1994","journal-title":"Sex Transm Dis"},{"key":"2024111411403325900_CIT0013","volume-title":"Clinical validation of a molecular test for ciprofloxacin-susceptibility in Neisseria gonorrhoeae","author":"Klausner"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/64\/9\/1268\/13635125\/ciw864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/64\/9\/1268\/13635125\/ciw864.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:58:34Z","timestamp":1731585514000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/64\/9\/1268\/2747463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,12,28]]},"published-print":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciw864","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,5,1]]},"published":{"date-parts":[[2016,12,28]]}}}