{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:15:38Z","timestamp":1790072138162,"version":"4.0.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"DOI":"10.1093\/cid\/cix042","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T23:08:48Z","timestamp":1486163328000},"page":"1066-1073","source":"Crossref","is-referenced-by-count":82,"title":["Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model"],"prefix":"10.1093","volume":"64","author":[{"given":"Hazel C.","family":"Dobinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malick M.","family":"Gibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena B.","family":"Thomaides-Brears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merryn","family":"Voysey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Darton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Waddington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Kerridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audino","family":"Podda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"D\u2019Alessio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy Pham","family":"Thanh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buddha","family":"Basnyat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Angus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron M.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Blohmke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,4]]},"reference":[{"key":"key\n\t\t\t\t20170522110134_CIT0001","doi-asserted-by":"crossref","first-page":"e2925","DOI":"10.1371\/journal.pntd.0002925","article-title":"Estimating the burden of paratyphoid a in Asia and Africa","volume":"8","author":"Arndt","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170522110134_CIT0002","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.tim.2014.06.007","article-title":"Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence","volume":"22","author":"Gunn","year":"2014","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20170522110134_CIT0003","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/ng1470","article-title":"Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid","volume":"36","author":"McClelland","year":"2004","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170522110134_CIT0004","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1128\/CVI.00058-12","article-title":"Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans","volume":"19","author":"Wahid","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"key\n\t\t\t\t20170522110134_CIT0005","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1086\/518141","article-title":"Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica serovar Paratyphi B","volume":"45","author":"Levine","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522110134_CIT0006","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1016\/j.vaccine.2016.03.106","article-title":"Status of paratyphoid fever vaccine research and development","volume":"34","author":"Martin","year":"2016","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20170522110134_CIT0007","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S1473-3099(15)00068-7","article-title":"Design, recruitment, and microbiological considerations in human challenge studies","volume":"15","author":"Darton","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20170522110134_CIT0008","volume-title":"Enteric fever (typhoid and paratyphoid) in England, Wales and Northern Ireland: 2014","author":"England","year":"2015"},{"key":"key\n\t\t\t\t20170522110134_CIT0009","doi-asserted-by":"crossref","first-page":"e007481","DOI":"10.1136\/bmjopen-2014-007481","article-title":"Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers","volume":"5","author":"McCullagh","year":"2015","journal-title":"BMJ Open"},{"key":"key\n\t\t\t\t20170522110134_CIT0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jinf.2012.05.005","article-title":"Guidelines for the public health management of typhoid and paratyphoid in England: practice guidelines from the National Typhoid and Paratyphoid Reference Group","volume":"65","author":"Balasegaram","year":"2012","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20170522110134_CIT0011","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cid\/ciu078","article-title":"An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella typhi challenge delivered in sodium bicarbonate solution","volume":"58","author":"Waddington","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522110134_CIT0012","volume-title":"R: a language and environment for statistical computing","author":"The R Core team"},{"key":"key\n\t\t\t\t20170522110134_CIT0013","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid fever","volume":"347","author":"Parry","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170522110134_CIT0014","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1128\/JCM.36.6.1683-1687.1998","article-title":"Quantitation of bacteria in blood of typhoid fever patients and relationship between counts and clinical features, transmissibility, and antibiotic resistance","volume":"36","author":"Wain","year":"1998","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170522110134_CIT0015","doi-asserted-by":"crossref","unstructured":"Proescher F . A report of forty-eight new cases of paratyphoid fever (type A). J Am Med Assoc1909; LII:470. Available at: http:\/\/jama.jamanetwork.com\/article.aspx?articleid=428987. Accessed 26 March 2016.","DOI":"10.1001\/jama.1909.25420320042003g"},{"key":"key\n\t\t\t\t20170522110134_CIT0016","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2471\/BLT.09.069310","article-title":"Trends and disease burden of enteric fever in Guangxi province, China, 1994\u20132004","volume":"88","author":"Dong","year":"2010","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t20170522110134_CIT0017","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/clinids\/9.4.841","article-title":"Control of typhoid fever in Bangkok, Thailand, by annual immunization of schoolchildren with parenteral typhoid vaccine","volume":"9","author":"Bodhidatta","year":"1987","journal-title":"Rev Infect Dis"},{"key":"key\n\t\t\t\t20170522110134_CIT0018","first-page":"1","article-title":"World Health Organization. Expert Committee on Biological Standardization","year":"2014","journal-title":"World Health Organ Tech Rep Ser"},{"key":"key\n\t\t\t\t20170522110134_CIT0019","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1086\/503033","article-title":"Salmonella enterica serovar Paratyphi A and S. enterica serovar Typhi cause indistinguishable clinical syndromes in Kathmandu, Nepal","volume":"42","author":"Maskey","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170522110134_CIT0020","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.trstmh.2004.09.012","article-title":"Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia","volume":"99","author":"Vollaard","year":"2005","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170522110134_CIT0021","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1056\/NEJM197009242831306","article-title":"Typhoid fever: pathogenesis and immunologic control","volume":"283","author":"Hornick","year":"1970","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170522110134_CIT0022","first-page":"704","article-title":"paratyphoid fever and meat poisoning","author":"Bainbridge","year":"1912","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170522110134_CIT0023","first-page":"143","article-title":"Paratyphoid fever in India","author":"Grattan","year":"1911","journal-title":"JR Army Med Corps"},{"key":"key\n\t\t\t\t20170522110134_CIT0024","first-page":"567","article-title":"Paratyphoid fever. An account of two epidemics with remarks on some clinical features of the disease","volume":"20","author":"Safford","year":"1912","journal-title":"JR Army Med Corps"},{"key":"key\n\t\t\t\t20170522110134_CIT0025","volume-title":"Performance standards for antimicrobial susceptibility testing: 24th informational supplement","author":"Clinical Laboratory and Standards Institute","year":"2014"},{"key":"key\n\t\t\t\t20170522110134_CIT0026","first-page":"0","volume-title":"Breakpoint tables for interpretation of MICs and zone diameters","author":"European Committee on Antimicrobial Susceptibility Testing.","year":"2016"},{"key":"key\n\t\t\t\t20170522110134_CIT0027","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1073\/pnas.1411012111","article-title":"Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever","volume":"111","author":"Zhou","year":"2014","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/64\/8\/1066\/17353254\/cix042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T19:33:08Z","timestamp":1601580788000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article-lookup\/doi\/10.1093\/cid\/cix042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,4]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,2,4]]},"published-print":{"date-parts":[[2017,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cix042","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,4]]}}}