{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T12:45:05Z","timestamp":1794573905252,"version":"4.9.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["305522"],"award-info":[{"award-number":["305522"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"DOI":"10.1093\/cid\/cix1124","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T21:39:03Z","timestamp":1514929143000},"page":"1899-1909","source":"Crossref","is-referenced-by-count":102,"title":["No Evidence for Accelerated Aging-Related Brain Pathology in Treated Human Immunodeficiency Virus: Longitudinal Neuroimaging Results From the Comorbidity in Relation to AIDS (COBRA) Project"],"prefix":"10.1093","volume":"66","author":[{"given":"James H","family":"Cole","sequence":"first","affiliation":[{"name":"Computational, Cognitive and Computational Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London"},{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthan W A","family":"Caan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Underwood","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Imperial College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"De Francesco","sequence":"additional","affiliation":[{"name":"Department of Infection and Population Health, University College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosan A","family":"van Zoest","sequence":"additional","affiliation":[{"name":"Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand W N M","family":"Wit","sequence":"additional","affiliation":[{"name":"Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development"},{"name":"Dutch HIV Monitoring Foundation, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J M M","family":"Mutsaerts","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"Kate Gleason College of Engineering, Rochester Institute of Technology, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Leech","sequence":"additional","affiliation":[{"name":"Computational, Cognitive and Computational Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert J","family":"Geurtsen","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Portegies","sequence":"additional","affiliation":[{"name":"Department of Neurology, OLVG Hospital"},{"name":"Department of Neurology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B L M","family":"Majoie","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F","family":"Schim van der Loeff","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Public Health Service of Amsterdam"},{"name":"Department of Infectious Diseases, Center for Immunity and Infection Amsterdam, Academic Medical Center, University of Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A","family":"Sabin","sequence":"additional","affiliation":[{"name":"Department of Infection and Population Health, University College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development"},{"name":"Dutch HIV Monitoring Foundation, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Winston","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Imperial College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Sharp","sequence":"additional","affiliation":[{"name":"Computational, Cognitive and Computational Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Comorbidity in Relations to AIDS (COBRA) Collaboration","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"key\n\t\t\t\t20180601005911_CIT0001","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338","author":"Palella","year":"1998","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180601005911_CIT0002","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/hiv.12421","article-title":"Life expectancy of HIV-positive people after starting combination antiretroviral therapy: a meta-analysis","volume":"18","author":"Teeraananchai","year":"2017","journal-title":"HIV Med"},{"key":"key\n\t\t\t\t20180601005911_CIT0003","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/cid\/ciu869","article-title":"Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults","volume":"60","author":"Althoff","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180601005911_CIT0004","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/QAD.0000000000000910","article-title":"HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls","volume":"30","author":"Kooij","year":"2016","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180601005911_CIT0005","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/cid\/ciu701","article-title":"Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study","volume":"59","author":"Schouten","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180601005911_CIT0006","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/cid\/cir627","article-title":"Premature age-related comorbidities among HIV-infected persons compared with the general population","volume":"53","author":"Guaraldi","year":"2011","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180601005911_CIT0007","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180601005911_CIT0008","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/QAD.0000000000001017","article-title":"Determinants of reduced cognitive performance in HIV-1-infected middle-aged men on combination antiretroviral therapy","volume":"30","author":"Schouten","year":"2016","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180601005911_CIT0009","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/QAD.0000000000000945","article-title":"White matter structure alterations in HIV-1-infected men with sustained suppression of viraemia on treatment","volume":"30","author":"Su","year":"2016","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180601005911_CIT0010","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/hbm.22674","article-title":"Multimodal neuroimaging evidence of alterations in cortical structure and function in HIV-infected older adults","volume":"36","author":"Wilson","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20180601005911_CIT0011","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00234-012-1061-5","article-title":"Two patterns of cerebral metabolite abnormalities are detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy","volume":"54","author":"Winston","year":"2012","journal-title":"Neuroradiology"},{"key":"key\n\t\t\t\t20180601005911_CIT0012","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/QAD.0000000000001414","article-title":"Cerebral blood flow and cognitive function in HIV-infected men with sustained suppressed viremia on combination antiretroviral therapy","volume":"31","author":"Su","year":"2017","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180601005911_CIT0013","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1097\/QAD.0000000000001133","article-title":"White matter hyperintensities in relation to cognition in HIV-infected men with sustained suppressed viral load on combination antiretroviral therapy","volume":"30","author":"Su","year":"2016","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180601005911_CIT0014","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/cid\/cix301","article-title":"Gray and white matter abnormalities in treated human immunodeficiency virus disease and their relationship to cognitive function","volume":"65","author":"Underwood","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180601005911_CIT0015","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1212\/WNL.0b013e318288792b","article-title":"Pathways to neurodegeneration: effects of HIV and aging on resting-state functional connectivity","volume":"80","author":"Thomas","year":"2013","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180601005911_CIT0016","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/QAI.0b013e318249db17","article-title":"Independent effects of HIV, aging, and HAART on brain volumetric measures","volume":"59","author":"Ances","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20180601005911_CIT0017","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hbm.23436","article-title":"The effects of HIV and aging on subcortical shape alterations: a 3D morphometric study","volume":"38","author":"Kuhn","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20180601005911_CIT0018","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00234-011-0854-2","article-title":"Factors affecting brain structure in men with HIV disease in the post-HAART era","volume":"54","author":"Becker","year":"2012","journal-title":"Neuroradiology"},{"key":"key\n\t\t\t\t20180601005911_CIT0019","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1212\/WNL.0b013e3181b59a97","article-title":"Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain","volume":"73","author":"Ances","year":"2009","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180601005911_CIT0020","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1212\/WNL.0000000000003790","article-title":"Increased brain-predicted aging in treated HIV disease","volume":"88","author":"Cole","year":"2017","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180601005911_CIT0021","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.idc.2014.05.001","article-title":"Global epidemiology of HIV","volume":"28","author":"Fettig","year":"2014","journal-title":"Infect Dis Clin North Am"},{"key":"key\n\t\t\t\t20180601005911_CIT0022","first-page":"49","article-title":"Serial MRI in HIV infection with and without neurologic impairment","volume":"1","author":"Dooneief","year":"1996","journal-title":"J NeuroAIDS"},{"key":"key\n\t\t\t\t20180601005911_CIT0023","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archneur.55.2.161","article-title":"Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. HIV Neurobehavioral Research Center Group","volume":"55","author":"Stout","year":"1998","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20180601005911_CIT0024","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/13550280902973960","article-title":"Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy","volume":"15","author":"Cardenas","year":"2009","journal-title":"J Neurovirol"},{"key":"key\n\t\t\t\t20180601005911_CIT0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13365-013-0162-1","article-title":"Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy","volume":"19","author":"Gongvatana","year":"2013","journal-title":"J Neurovirol"},{"key":"key\n\t\t\t\t20180601005911_CIT0026","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.neurobiolaging.2014.01.008","article-title":"Accelerated aging of selective brain structures in human immunodeficiency virus infection: a controlled, longitudinal magnetic resonance imaging study","volume":"35","author":"Pfefferbaum","year":"2014","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t20180601005911_CIT0027","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/jmri.25263","article-title":"Longitudinal assessment of subcortical gray matter volume, cortical thickness, and white matter integrity in HIV-positive patients","volume":"44","author":"Corr\u00eaa","year":"2016","journal-title":"J Magn Reson Imaging"},{"key":"key\n\t\t\t\t20180601005911_CIT0028","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/QAI.0000000000001489","article-title":"Progressive brain atrophy despite persistent viral suppression in HIV over age 60","volume":"76","author":"Clifford","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20180601005911_CIT0029","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1002\/hbm.23326","article-title":"Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification","volume":"37","author":"Zhang","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"key\n\t\t\t\t20180601005911_CIT0030","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/mp.2014.187","article-title":"Cigarette smoking and thinning of the brain\u2019s cortex","volume":"20","author":"Karama","year":"2015","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20180601005911_CIT0031","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11065-007-9038-6","article-title":"Alcohol: effects on neurobehavioral functions and the brain","volume":"17","author":"Oscar-Berman","year":"2007","journal-title":"Neuropsychol Rev"},{"key":"key\n\t\t\t\t20180601005911_CIT0032","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1007\/s00429-017-1414-2","article-title":"Risk and protective factors for structural brain ageing in the eighth decade of life","volume":"222","author":"Ritchie","year":"2017","journal-title":"Brain Struct Func"},{"key":"key\n\t\t\t\t20180601005911_CIT0033","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/infdis\/jix553","article-title":"Structural brain abnormalities in successfully treated HIV infection: associations with disease and cerebrospinal fluid biomarkers","volume":"217","author":"Van Zoest","year":"2017","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180601005911_CIT0034","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2015"},{"key":"key\n\t\t\t\t20180601005911_CIT0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20180601005911_CIT0036","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1212\/01.WNL.0000110315.26026.EF","article-title":"Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD","volume":"62","author":"Jack","year":"2004","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180601005911_CIT0037","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3109\/02699052.2011.624568","article-title":"Review of longitudinal studies of MRI brain volumetry in patients with traumatic brain injury","volume":"25","author":"Ross","year":"2011","journal-title":"Brain Inj"},{"key":"key\n\t\t\t\t20180601005911_CIT0038","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1212\/01.WNL.0000161871.83614.BB","article-title":"Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects","volume":"64","author":"Enzinger","year":"2005","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180601005911_CIT0039","doi-asserted-by":"crossref","first-page":"e92842","DOI":"10.1371\/journal.pone.0092842","article-title":"Excess burden of depression among HIV-infected persons receiving medical care in the United States: data from the medical monitoring project and the behavioral risk factor surveillance system","volume":"9","author":"Do","year":"2014","journal-title":"PLoS One"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/66\/12\/1899\/24965892\/cix1124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:26:42Z","timestamp":1570562802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/66\/12\/1899\/4788363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,4]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,1,4]]},"published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cix1124","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,6,15]]},"published":{"date-parts":[[2018,1,4]]}}}