{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:25:39Z","timestamp":1775795139992,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"suppl_3","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,15]]},"DOI":"10.1093\/cid\/cix148","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T08:06:04Z","timestamp":1496131564000},"page":"S337-S346","source":"Crossref","is-referenced-by-count":80,"title":["Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study"],"prefix":"10.1093","volume":"64","author":[{"given":"Daniel R.","family":"Feikin","sequence":"first","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Department of Rheumatology, Johns Hopkins School of Medicine, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Milken Institute School of Public Health, Department of Epidemiology and Biostatistics, George Washington University, District of Columbia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Higdon","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Baggett","sequence":"additional","affiliation":[{"name":"Global Disease Detection Center, Thailand Ministry of Public Health\u2013US Centers for Disease Control and Prevention Collaboration, Nonthaburi;"},{"name":"Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Abdullah","family":"Brooks","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka and Matlab;"},{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Deloria Knoll","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Hammitt","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Kenya Medical Research Institute\u2013Wellcome Trust Research Programme, Kilifi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R. C.","family":"Howie","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, Basse, The Gambia;"},{"name":"Department of Paediatrics, University of Auckland, and"},{"name":"Centre for International Health, University of Otago, Dunedin, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Kotloff","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, Institute of Global Health, University of Maryland School of Medicine, Baltimore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orin S.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Bill & Melinda Gates Foundation, Seattle, Washington;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabir A.","family":"Madhi","sequence":"additional","affiliation":[{"name":"Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, and"},{"name":"Department of Science and Technology\/National Research Foundation, Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Anthony G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\u2013Wellcome Trust Research Programme, Kilifi;"},{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Thea","sequence":"additional","affiliation":[{"name":"Center for Global Health and Development, Boston University School of Public Health, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter V.","family":"Adrian","sequence":"additional","affiliation":[{"name":"Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, and"},{"name":"Department of Science and Technology\/National Research Foundation, Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Antonio","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, Basse, The Gambia;"},{"name":"Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, and"},{"name":"Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet O.","family":"Awori","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\u2013Wellcome Trust Research Programme, Kilifi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky L.","family":"Baillie","sequence":"additional","affiliation":[{"name":"Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, and"},{"name":"Department of Science and Technology\/National Research Foundation, Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Department of Epidemiology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard E.","family":"Ebruke","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, Basse, The Gambia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doli","family":"Goswami","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka and Matlab;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth A.","family":"Karron","sequence":"additional","affiliation":[{"name":"Department of International Health, Center for Immunization Research, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan C.","family":"Morpeth","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\u2013Wellcome Trust Research Programme, Kilifi;"},{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, United Kingdom;"},{"name":"Microbiology Laboratory, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mwaba","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University Teaching Hospital, and"},{"name":"Zambia Center for Applied Health Research and Development, Lusaka;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Mwansa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University Teaching Hospital, and"},{"name":"Zambia Center for Applied Health Research and Development, Lusaka;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Prosperi","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongpun","family":"Sawatwong","sequence":"additional","affiliation":[{"name":"Global Disease Detection Center, Thailand Ministry of Public Health\u2013US Centers for Disease Control and Prevention Collaboration, Nonthaburi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samba O.","family":"Sow","sequence":"additional","affiliation":[{"name":"Centre pour le D\u00e9veloppement des Vaccins (CVD-Mali), Bamako;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milagritos D.","family":"Tapia","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, Institute of Global Health, University of Maryland School of Medicine, Baltimore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Whistler","sequence":"additional","affiliation":[{"name":"Global Disease Detection Center, Thailand Ministry of Public Health\u2013US Centers for Disease Control and Prevention Collaboration, Nonthaburi;"},{"name":"Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalequ","family":"Zaman","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka and Matlab;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott L.","family":"Zeger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"O\u2019 Brien","sequence":"additional","affiliation":[{"name":"Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Murdoch","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Otago, and"},{"name":"Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the PERCH Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orin S.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Deloria","family":"Knoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Feikin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"DeLuca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Fancourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Hammitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Higdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Wangeci","family":"Kagucia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth A.","family":"Karron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Prosperi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott L.","family":"Zeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora L.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Crawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Abdullah","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert P.","family":"Endtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalequ","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doli","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokman","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R. C.","family":"Howie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard E.","family":"Ebruke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"McLellan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice","family":"Machuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arifin","family":"Shamsul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed M.A.","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Anthony G.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet O.","family":"Awori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan C.","family":"Morpeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Kamau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidi","family":"Kazungu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah Silaba","family":"Ominde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Kotloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milagritos D.","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samba O.","family":"Sow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou","family":"Sylla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubou","family":"Tamboura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Onwuchekwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Kourouma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliou","family":"Toure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabir A.","family":"Madhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter V.","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky L.","family":"Baillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Locadiah","family":"Kuwanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azwifarwi","family":"Mudau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle J.","family":"Groome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasreen","family":"Mahomed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Baggett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"Thamthitiwat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Maloney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charatdao","family":"Bunthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongpun","family":"Sawatwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasakorn","family":"Akarasewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Thea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Mwananyanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Chipeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Seidenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Mwansa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somwe","family":"wa Somwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Kwenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor P.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,5,29]]},"reference":[{"key":"key\n\t\t\t\t20180328155722_CIT0001","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1093\/cid\/cir1068","article-title":"Specimen collection for the diagnosis of pediatric pneumonia","volume":"54","author":"Hammitt","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0002","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(10)61459-6","article-title":"Viral pneumonia","volume":"377","author":"Ruuskanen","year":"2011","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328155722_CIT0003","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1128\/JCM.01685-09","article-title":"Breathing new life into pneumonia diagnostics","volume":"47","author":"Murdoch","year":"2009","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180328155722_CIT0004","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1128\/JCM.02094-10","article-title":"Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values","volume":"49","author":"Jansen","year":"2011","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180328155722_CIT0005","article-title":"Density of upper respiratory colonization with Streptococcus pneumoniae and its role in the diagnosis of pneumococcal pneumonia among children aged <5 years in the PERCH study","volume":"64(suppl 3):S317\u201327","author":"Baggett","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0006","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/cid\/cir859","article-title":"Use of a rapid test of pneumococcal colonization density to diagnose pneumococcal pneumonia","volume":"54","author":"Albrich","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0007","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/jmv.23455","article-title":"Association of the CT values of real-time PCR of viral upper respiratory tract infection with clinical severity, Kenya","volume":"85","author":"Fuller","year":"2013","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t20180328155722_CIT0008","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1097\/INF.0b013e3181ff2fac","article-title":"The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department","volume":"30","author":"Utokaparch","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180328155722_CIT0009","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00006454-200002000-00006","article-title":"Nasal quantity of respiratory syncytial virus correlates with disease severity in hospitalized infants","volume":"19","author":"Buckingham","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180328155722_CIT0010","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1086\/430008","article-title":"Respiratory syncytial virus load predicts disease severity in previously healthy infants","volume":"191","author":"DeVincenzo","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0011","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1164\/rccm.201002-0221OC","article-title":"Viral load drives disease in humans experimentally infected with respiratory syncytial virus","volume":"182","author":"DeVincenzo","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180328155722_CIT0012","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1093\/cid\/cir1066","article-title":"Identification and selection of cases and controls in the pneumonia etiology research for child health project","volume":"54","author":"Deloria-Knoll","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0013","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1093\/cid\/cir1065","article-title":"The definition of pneumonia, the assessment of severity, and clinical standardization in the Pneumonia Etiology Research for Child Health study","volume":"54","author":"Scott","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0014","first-page":"353","article-title":"Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies","volume":"83","author":"Cherian","year":"2005","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t20180328155722_CIT0015","article-title":"Standardization of laboratory methods for the pneumonia etiology research for child health study","volume":"64(suppl 3):S245\u201352","author":"Driscoll","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0016","article-title":"Colonization density of the upper respiratory tract as a predictor of pneumonia\u2014Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii","volume":"64(suppl 3):S328\u201336","author":"Park","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0017","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/02724936.1997.11747904","article-title":"Bacterial isolates from blood and lung aspirate cultures in Gambian children with lobar pneumonia","volume":"17","author":"Falade","year":"1997","journal-title":"Ann Trop Paediatr"},{"key":"key\n\t\t\t\t20180328155722_CIT0018","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"key":"key\n\t\t\t\t20180328155722_CIT0019","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1373\/clinchem.2007.096032","article-title":"Bias in sensitivity and specificity caused by data-driven selection of optimal cutoff values: mechanisms, magnitude, and solutions","volume":"54","author":"Leeflang","year":"2008","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20180328155722_CIT0020","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/jmv.21026","article-title":"Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity","volume":"79","author":"Fodha","year":"2007","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t20180328155722_CIT0021","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jmv.21771","article-title":"Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community","volume":"82","author":"Houben","year":"2010","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t20180328155722_CIT0022","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/INF.0b013e3181b6de8a","article-title":"Quantitation of respiratory viruses in relation to clinical course in children with acute respiratory tract infections","volume":"29","author":"Jansen","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180328155722_CIT0023","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jcv.2010.05.007","article-title":"Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection","volume":"48","author":"Franz","year":"2010","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20180328155722_CIT0024","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.diagmicrobio.2008.08.002","article-title":"Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus","volume":"62","author":"Martin","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0025","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1086\/339822","article-title":"Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus","volume":"185","author":"Wright","year":"2002","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0026","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/infdis\/140.4.610","article-title":"Viral shedding patterns of children with influenza B infection","volume":"140","author":"Hall","year":"1979","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0027","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3201\/eid1702.100282","article-title":"Comparison of pandemic (H1N1) 2009 and seasonal influenza viral loads, Singapore","volume":"17","author":"Lee","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0028","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3201\/eid1608.091918","article-title":"Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children","volume":"16","author":"Li","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0029","first-page":"746","article-title":"The relationship between chest CT findings and viral load in patients with novel influenza A (H1N1)","volume":"33","author":"Lu","year":"2010","journal-title":"Natl Cent Biotechnol Inf"},{"key":"key\n\t\t\t\t20180328155722_CIT0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1469-0691.2010.03169.x","article-title":"Pandemic A(H1N1)2009 influenza virus detection by real time RT-PCR: is viral quantification useful?","volume":"16","author":"Duchamp","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180328155722_CIT0031","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-2334-11-140","article-title":"Duration of viral shedding in hospitalized patients infected with pandemic H1N1","volume":"11","author":"Meschi","year":"2011","journal-title":"BMC Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0032","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1086\/650581","article-title":"Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection","volume":"50","author":"To","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0033","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jcv.2008.03.029","article-title":"Association between high nasopharyngeal viral load and disease severity in children with human metapneumovirus infection","volume":"42","author":"Bosis","year":"2008","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20180328155722_CIT0034","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jcv.2007.08.001","article-title":"Prospective study of human metapneumovirus infection: diagnosis, typing and virus quantification in nasopharyngeal secretions from pediatric patients","volume":"40","author":"Gerna","year":"2007","journal-title":"J Clin Virol"},{"key":"key\n\t\t\t\t20180328155722_CIT0035","article-title":"High human bocavirus viral load is associated with disease severity in children under five years of age","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328155722_CIT0036","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1038\/nm1143","article-title":"Severe acute respiratory syndrome","volume":"10","author":"Peiris","year":"2004","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180328155722_CIT0037","article-title":"Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014","volume":"21:2029\u201335","author":"Feikin","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180328155722_CIT0038","article-title":"Bayesian estimation of pneumonia etiology: epidemiologic considerations and applications to pneumonia etiology research for child health study","volume":"64(suppl 3):S213\u201327","author":"Deloria Knoll","year":"2017","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/64\/suppl_3\/S337\/20916397\/cix148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T03:19:16Z","timestamp":1522293556000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/64\/suppl_3\/S337\/3858230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,29]]},"references-count":38,"journal-issue":{"issue":"suppl_3","published-online":{"date-parts":[[2017,5,29]]},"published-print":{"date-parts":[[2017,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cix148","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,6,15]]},"published":{"date-parts":[[2017,5,29]]}}}