{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:58:44Z","timestamp":1789855124917,"version":"4.0.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,15]]},"DOI":"10.1093\/cid\/cix278","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:51:51Z","timestamp":1490143911000},"page":"276-281","source":"Crossref","is-referenced-by-count":50,"title":["Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial"],"prefix":"10.1093","volume":"65","author":[{"given":"Beatrice","family":"Barda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somphou","family":"Sayasone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khampheng","family":"Phongluxa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syda","family":"Xayavong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khonsavanh","family":"Keoduangsy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Puchkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Huwyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hattendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,25]]},"reference":[{"key":"key\n\t\t\t\t20170630041941_CIT0001","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.trstmh.2009.02.013","article-title":"Strongyloidiasis\u2013the most neglected of the neglected tropical diseases?","volume":"103","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20170630041941_CIT0002","first-page":"5","article-title":"Advocating for both environmental and clinical approaches to control human strongyloidiasis","year":"2016","journal-title":"Pathog Basel Switz"},{"key":"key\n\t\t\t\t20170630041941_CIT0003","doi-asserted-by":"crossref","first-page":"e2214","DOI":"10.1371\/journal.pntd.0002214","article-title":"Strongyloides stercoralis: a plea for action","volume":"7","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0004","doi-asserted-by":"crossref","first-page":"e2288","DOI":"10.1371\/journal.pntd.0002288","article-title":"Strongyloides stercoralis: global distribution and risk factors","volume":"7","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0005","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.parint.2014.06.001","article-title":"Strongyloides stercoralis infection and re-infection in a cohort of children in Cambodia","volume":"63","year":"2014","journal-title":"Parasitol Int"},{"key":"key\n\t\t\t\t20170630041941_CIT0006","first-page":"CD007745","article-title":"Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20170630041941_CIT0007","first-page":"5","article-title":"Efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0008","first-page":"10","article-title":"Ivermectin treatment and sanitation effectively reduce Strongyloides stercoralis infection risk in rural communities in Cambodia","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0009","doi-asserted-by":"crossref","first-page":"e2035","DOI":"10.1371\/journal.pntd.0002035","article-title":"Diagnosis, treatment and risk factors of Strongyloides stercoralis in schoolchildren in Cambodia","volume":"7","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0010","first-page":"442","article-title":"Prevalence of strongyloides in northern Thailand and treatment with ivermectin vs albendazole","volume":"36","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"key\n\t\t\t\t20170630041941_CIT0011","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1292\/jvms.56.779","article-title":"Prophylactic efficacy of milbemycin oxime against multiple infection of dogs with Dirofilaria immitis","volume":"56","year":"1994","journal-title":"J Vet Med Sci"},{"key":"key\n\t\t\t\t20170630041941_CIT0012","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-0684.2006.00154.x","article-title":"Comparison of efficacy of moxidectin and ivermectin in the treatment of Strongyloides fulleborni infection in rhesus macaques","volume":"35","year":"2006","journal-title":"J Med Primatol"},{"key":"key\n\t\t\t\t20170630041941_CIT0013","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2885.2012.01424.x","article-title":"Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin","volume":"36","year":"2013","journal-title":"J Vet Pharmacol Ther"},{"key":"key\n\t\t\t\t20170630041941_CIT0014","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0020-7519(01)00174-6","article-title":"Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin\/milbemycins","volume":"31","year":"2001","journal-title":"Int J Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0015","volume-title":"Diagnostic Medical Parasitology","year":"2001"},{"key":"key\n\t\t\t\t20170630041941_CIT0016","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","year":"1972","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"key\n\t\t\t\t20170630041941_CIT0017","doi-asserted-by":"crossref","first-page":"e2854","DOI":"10.1371\/journal.pntd.0002854","article-title":"High prevalence and spatial distribution of Strongyloides stercoralis in rural Cambodia","volume":"8","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0018","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.actatropica.2014.09.016","article-title":"Epidemiology of Strongyloides stercoralis on Mekong islands in southern Laos","volume":"141","year":"2015","journal-title":"Acta Trop"},{"key":"key\n\t\t\t\t20170630041941_CIT0019","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-3156.2004.01234.x","article-title":"Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, northeast Thailand","volume":"9","year":"2004","journal-title":"Trop Med Int Health"},{"key":"key\n\t\t\t\t20170630041941_CIT0020","first-page":"i","article-title":"Prevention and control of schistosomiasis and soil-transmitted helminthiasis","volume":"912","author":"WHO Expert Committee","year":"2002","journal-title":"World Health Organ Tech Rep Ser"},{"key":"key\n\t\t\t\t20170630041941_CIT0021","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/S2214-109X(13)70078-0","article-title":"The drug and vaccine landscape for neglected diseases (2000-11): a systematic assessment","volume":"1","year":"2013","journal-title":"Lancet Glob Health"},{"key":"key\n\t\t\t\t20170630041941_CIT0022","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpddr.2014.07.002","article-title":"Repurposing drugs for the treatment and control of helminth infections","volume":"4","year":"2014","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"key\n\t\t\t\t20170630041941_CIT0023","first-page":"325","article-title":"Over 25 years of clinical experience with ivermectin: an overview of safety for an increasing number of indications","volume":"15","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"key\n\t\t\t\t20170630041941_CIT0024","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1177\/009127002401382731","article-title":"Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects","volume":"42","year":"2002","journal-title":"J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170630041941_CIT0025","first-page":"204","article-title":"Safety of oral ivermectin in children","volume":"23","year":"2016","journal-title":"Arch Pediatr"},{"key":"key\n\t\t\t\t20170630041941_CIT0026","doi-asserted-by":"crossref","first-page":"e0005008","DOI":"10.1371\/journal.pntd.0005008","article-title":"Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against Schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial","volume":"10","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"key\n\t\t\t\t20170630041941_CIT0027","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0020-7519(99)00074-0","article-title":"Selection for anthelmintic resistance by macrocyclic lactones in Haemonchus contortus","volume":"29","year":"1999","journal-title":"Int J Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0028","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0304-4017(92)90090-V","article-title":"Efficacy of moxidectin against an ivermectin-resistant strain of Haemonchus contortus in sheep","volume":"41","year":"1992","journal-title":"Vet Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0029","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-4017(02)00247-9","article-title":"Resistance to therapeutic treatment with macrocyclic lactone anthelmintics in Ostertagia circumcincta","volume":"109","year":"2002","journal-title":"Vet Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.vetpar.2016.06.033","article-title":"Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France","volume":"226","year":"2016","journal-title":"Vet Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0031","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.vetpar.2011.07.013","article-title":"A review of parasitic zoonoses in a changing Southeast Asia","volume":"182","year":"2011","journal-title":"Vet Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0032","first-page":"113","article-title":"Clinical observation on the efficacy of ivermectin in the treatment of intestinal nematode infections","volume":"21","year":"2003","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"key":"key\n\t\t\t\t20170630041941_CIT0033","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.actatropica.2008.03.007","article-title":"A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in China","volume":"106","year":"2008","journal-title":"Acta Trop"},{"key":"key\n\t\t\t\t20170630041941_CIT0034","first-page":"279","article-title":"Clinical observation on efficacy of ivermectin in the treatment of intestinal nematode infections","volume":"10","year":"1992","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"key":"key\n\t\t\t\t20170630041941_CIT0035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2307\/3282591","article-title":"Efficacy of ivermectin in hookworms as examined in Ancylostoma caninum infections","volume":"75","year":"1989","journal-title":"J Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0036","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-4017(95)00925-6","article-title":"Efficacy of moxidectin pour-on against gastrointestinal nematodes and Dictyocaulus viviparus in cattle","volume":"64","year":"1996","journal-title":"Vet Parasitol"},{"key":"key\n\t\t\t\t20170630041941_CIT0037","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jgar.2015.08.004","article-title":"Monitoring the efficacy of drugs for neglected tropical diseases controlled by preventive chemotherapy","volume":"3","year":"2015","journal-title":"J Glob Antimicrob Resist"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/65\/2\/276\/17983355\/cix278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T16:15:31Z","timestamp":1503591331000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article-lookup\/doi\/10.1093\/cid\/cix278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,25]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,3,25]]},"published-print":{"date-parts":[[2017,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cix278","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,25]]}}}