{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:40:08Z","timestamp":1790300408933,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,15]]},"DOI":"10.1093\/cid\/cix373","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T11:14:18Z","timestamp":1492514058000},"page":"595-603","source":"Crossref","is-referenced-by-count":65,"title":["Cerebral Abscess Associated With Odontogenic Bacteremias, Hypoxemia, and Iron Loading in Immunocompetent Patients With Right-to-Left Shunting Through Pulmonary Arteriovenous Malformations"],"prefix":"10.1093","volume":"65","author":[{"given":"Emily J.","family":"Boother","sequence":"first","affiliation":[{"name":"Cardiovascular Translational Sciences, National Heart and Lung Institute and"},{"name":"Imperial College School of Medicine, Imperial College London, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Brownlow","sequence":"additional","affiliation":[{"name":"Respiratory Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C.","family":"Tighe","sequence":"additional","affiliation":[{"name":"Respiratory Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B.","family":"Bamford","sequence":"additional","affiliation":[{"name":"Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Shovlin","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Sciences, National Heart and Lung Institute and"},{"name":"Respiratory Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"key\n\t\t\t\t20180306212455_CIT0001","first-page":"CD004469","article-title":"Antibiotics for brain abscesses in people with cyanotic congenital heart disease","volume":"3","author":"Lumbiganon","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180306212455_CIT0002","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.201407-1254CI","article-title":"Pulmonary arteriovenous malformations","volume":"190","author":"Shovlin","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180306212455_CIT0003","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.crad.2014.09.003","article-title":"Pulmonary arteriovenous malformations and their mimics","volume":"70","author":"Gill","year":"2015","journal-title":"Clin Radiol"},{"key":"key\n\t\t\t\t20180306212455_CIT0004","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2169\/internalmedicine.51.7305","article-title":"Prevalence of pulmonary arteriovenous malformations as estimated by low-dose thoracic CT screening","volume":"51","author":"Nakayama","year":"2012","journal-title":"Intern Med"},{"key":"key\n\t\t\t\t20180306212455_CIT0005","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00104-2016","article-title":"Pulmonary arteriovenous malformations: evidence of physician under-education","volume":"3","author":"Shovlin","year":"2017","journal-title":"ERJ Open Res"},{"key":"key\n\t\t\t\t20180306212455_CIT0006","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00000658-195502000-00016","article-title":"Brain abscess associated with pulmonary arterio-venous fistula","volume":"141","author":"Chambers","year":"1955","journal-title":"Ann Surg"},{"key":"key\n\t\t\t\t20180306212455_CIT0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/QCO.0000000000000334","article-title":"Epidemiology, diagnosis, and treatment of brain abscesses","volume":"30","author":"Brouwer","year":"2017","journal-title":"Curr Opin Infect Dis"},{"key":"key\n\t\t\t\t20180306212455_CIT0008","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/thx.2007.087452","article-title":"Primary determinants of ischaemic stroke\/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia","volume":"63","author":"Shovlin","year":"2008","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20180306212455_CIT0009","doi-asserted-by":"crossref","first-page":"e88812","DOI":"10.1371\/journal.pone.0088812","article-title":"Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: associations with iron deficiency and platelets","volume":"9","author":"Shovlin","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306212455_CIT0010","doi-asserted-by":"crossref","first-page":"e90777","DOI":"10.1371\/journal.pone.0090777","article-title":"Arterial oxygen content is precisely maintained by graded erythrocytotic responses in settings of high\/normal serum iron levels, and predicts exercise capacity: an observational study of hypoxaemic patients with pulmonary arteriovenous malformations","volume":"9","author":"Santhirapala","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306212455_CIT0011","doi-asserted-by":"crossref","DOI":"10.1513\/AnnalsATS.201611-872OC","article-title":"Hemoglobin is a vital determinant of arterial oxygen content in hypoxemic patients with PAVMs [manuscript published online ahead of print 7 March 2017]","author":"Rizvi","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"key\n\t\t\t\t20180306212455_CIT0012","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1378\/chest.13-2988","article-title":"Cardiopulmonary exercise testing demonstrates maintenance of exercise capacity in patients with hypoxemia and pulmonary arteriovenous malformations","volume":"146","author":"Howard","year":"2014","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180306212455_CIT0013","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1212\/WNL.55.7.959","article-title":"Pulmonary arteriovenous malformations: cerebral ischemia and neurologic manifestations","volume":"55","author":"Moussouttas","year":"2000","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180306212455_CIT0014","first-page":"375","article-title":"What makes a good lung?","volume":"139","author":"Weibel","year":"2009","journal-title":"Swiss Med Wkly"},{"key":"key\n\t\t\t\t20180306212455_CIT0015","first-page":"CD008017","article-title":"Embolisation for pulmonary arteriovenous malformation","volume":"8","author":"Hsu","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180306212455_CIT0016","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.blre.2010.07.001","article-title":"Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment","volume":"24","author":"Shovlin","year":"2010","journal-title":"Blood Rev"},{"key":"key\n\t\t\t\t20180306212455_CIT0017","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1164\/rccm.200310-1441OC","article-title":"Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia","volume":"169","author":"Cottin","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20180306212455_CIT0018","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/thoraxjnl-2013-203720","article-title":"The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study","volume":"69","author":"Donaldson","year":"2014","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20180306212455_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2015.00001","article-title":"Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era","volume":"6","author":"McDonald","year":"2015","journal-title":"Front Genet"},{"key":"key\n\t\t\t\t20180306212455_CIT0020","doi-asserted-by":"crossref","first-page":"e76516","DOI":"10.1371\/journal.pone.0076516","article-title":"Hemorrhage-adjusted iron requirements, hematinics and hepcidin define hereditary hemorrhagic telangiectasia as a model of hemorrhagic iron deficiency","volume":"8","author":"Finnamore","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306212455_CIT0021","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.clineuro.2011.10.036","article-title":"Cerebral abscesses in hereditary haemorrhagic telangiectasia: a clinical and microbiological evaluation","volume":"114","author":"Mathis","year":"2012","journal-title":"Clin Neurol Neurosurg"},{"key":"key\n\t\t\t\t20180306212455_CIT0022","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/sj.bdj.2008.978","article-title":"Post-NICE 2008: Antibiotic prophylaxis prior to dental procedures for patients with pulmonary arteriovenous malformations (PAVMs) and hereditary haemorrhagic telangiectasia","volume":"205","author":"Shovlin","year":"2008","journal-title":"Br Dent J"},{"key":"key\n\t\t\t\t20180306212455_CIT0023","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1093\/jac\/dkw081","article-title":"Intravenous amoxicillin\/clavulanate for the prevention of bacteraemia following dental procedures: a randomized clinical trial","volume":"71","author":"Limeres Posse","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180306212455_CIT0024","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1378\/chest.12-1599","article-title":"Grade of pulmonary right-to-left shunt on contrast echocardiography and cerebral complications: a striking association","volume":"144","author":"Velthuis","year":"2013","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180306212455_CIT0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1183\/09031936.00133713","article-title":"Predicting the size of pulmonary arteriovenous malformations on chest computed tomography: a role for transthoracic contrast echocardiography","volume":"44","author":"Velthuis","year":"2014","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20180306212455_CIT0026","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1152\/japplphysiol.00565.2012","article-title":"Catecholamine-induced opening of intrapulmonary arteriovenous anastomoses in healthy humans at rest","volume":"113","author":"Laurie","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"key\n\t\t\t\t20180306212455_CIT0027","volume-title":"Oxygen transport. In: Regulation of tissue oxygenation","author":"Pittman","year":"2011"},{"key":"key\n\t\t\t\t20180306212455_CIT0028","article-title":"Long-term outcomes of patients with pulmonary arteriovenous malformations considered for lung transplantation","author":"Shovlin","year":"2017","journal-title":"compared to similarly hypoxemic cohorts"},{"key":"key\n\t\t\t\t20180306212455_CIT0029","author":"Duchini","year":"2016"},{"key":"key\n\t\t\t\t20180306212455_CIT0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/INF.0b013e3182748d6e","article-title":"Clinical and microbiologic features guiding treatment recommendations for brain abscesses in children","volume":"32","author":"Felsenstein","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t20180306212455_CIT0031","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/ane.12167","article-title":"Cerebral abscesses among Danish patients with hereditary haemorrhagic telangiectasia","volume":"129","author":"Kjeldsen","year":"2014","journal-title":"Acta Neurol Scand"},{"key":"key\n\t\t\t\t20180306212455_CIT0032","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/lary.25959","article-title":"Can iron treatments aggravate epistaxis in some patients with hereditary hemorrhagic telangiectasia?","volume":"126","author":"Shovlin","year":"2016","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20180306212455_CIT0033","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5582\/irdr.2016.01019","article-title":"Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia\u2014an observational study","volume":"5","author":"Chamali","year":"2016","journal-title":"Intractable Rare Dis Res"},{"key":"key\n\t\t\t\t20180306212455_CIT0034","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mib.2015.07.005","article-title":"Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections","volume":"27","author":"Bruhn","year":"2015","journal-title":"Curr Opin Microbiol"},{"key":"key\n\t\t\t\t20180306212455_CIT0035","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1099\/mic.0.071928-0","article-title":"Role of porin proteins in acquisition of transferrin iron by enteropathogens","volume":"159","author":"Sandrini","year":"2013","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180306212455_CIT0036","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/JB.01028-09","article-title":"Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin","volume":"192","author":"Sandrini","year":"2010","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180306212455_CIT0037","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1212\/WNL.23.11.1205","article-title":"Brain abscess from septic cerebral embolism: an experimental model","volume":"23","author":"Molinari","year":"1973","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180306212455_CIT0038","doi-asserted-by":"crossref","first-page":"e0147990","DOI":"10.1371\/journal.pone.0147990","article-title":"Low dose iron treatments induce a DNA damage response in human endothelial cells within minutes","volume":"11","author":"Mollet","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306212455_CIT0039","doi-asserted-by":"crossref","first-page":"e0120826","DOI":"10.1371\/journal.pone.0120826","article-title":"Viable bacteria associated with red blood cells and plasma in freshly drawn blood donations","volume":"10","author":"Damgaard","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180306212455_CIT0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fmed.2016.00060","article-title":"A dormant microbial component in the development of preeclampsia","volume":"3","author":"Kell","year":"2016","journal-title":"Front Med"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/65\/4\/595\/24266345\/cix373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T18:04:43Z","timestamp":1601921083000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/65\/4\/595\/3743801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,19]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,19]]},"published-print":{"date-parts":[[2017,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cix373","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8,15]]},"published":{"date-parts":[[2017,4,19]]}}}