{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:39:13Z","timestamp":1787611153976,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/cid\/cix477","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T23:08:57Z","timestamp":1495494537000},"page":"1222-1225","source":"Crossref","is-referenced-by-count":83,"title":["Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia"],"prefix":"10.1093","volume":"65","author":[{"given":"Matthew S","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars F","family":"Westblade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Dziedziech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E","family":"Visone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R","family":"Furman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey N","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A","family":"Kirkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"key\n\t\t\t\t20170914213442_CIT0001","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/525852","article-title":"Persistent and relapsing babesiosis in immunocompromised patients","volume":"46","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170914213442_CIT0002","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170914213442_CIT0003","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1086\/649859","article-title":"Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection","volume":"50","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170914213442_CIT0004","doi-asserted-by":"crossref","first-page":"16079","DOI":"10.1038\/nmicrobiol.2016.79","article-title":"A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse","volume":"1","year":"2016","journal-title":"Nat Microbiol"},{"key":"key\n\t\t\t\t20170914213442_CIT0005","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1038\/ncomms5029","article-title":"Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action","volume":"5","year":"2014","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20170914213442_CIT0006","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1074\/jbc.M608615200","article-title":"In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin","volume":"282","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170914213442_CIT0007","doi-asserted-by":"crossref","first-page":"e107939","DOI":"10.1371\/journal.pone.0107939","article-title":"Sequence and annotation of the apicoplast genome of the human pathogen Babesia microti","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170914213442_CIT0008","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1128\/AAC.44.8.2100-2108.2000","article-title":"Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site","volume":"44","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170914213442_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(00)00184-5","article-title":"Characterization of cytochrome b from Toxoplasma gondii and Qo domain mutations as a mechanism of atovaquone-resistance","volume":"108","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"key\n\t\t\t\t20170914213442_CIT0010","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1086\/314509","article-title":"Sequence polymorphisms in the Pneumocystis carinii cytochrome b gene and their association with atovaquone prophylaxis failure","volume":"178","year":"1998","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170914213442_CIT0011","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/AAC.46.3.654-658.2002","article-title":"Ribosomal mutations in Streptococcus pneumoniae clinical isolates","volume":"46","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170914213442_CIT0012","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4269\/ajtmh.1996.55.219","article-title":"Atovaquone in the treatment of Babesia microti infections in hamsters","volume":"55","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t20170914213442_CIT0013","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.diagmicrobio.2016.02.016","article-title":"Persistence of babesiosis for >2 years in a patient on rituximab for rheumatoid arthritis","volume":"85","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20170914213442_CIT0014","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1001\/jama.2016.2884","article-title":"Diagnosis, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: a review","volume":"315","year":"2016","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170914213442_CIT0015","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1056\/NEJM199807163390304","article-title":"Persistent parasitemia after acute babesiosis","volume":"339","year":"1998","journal-title":"N Engl J Med"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/65\/7\/1222\/19918672\/cix477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T19:14:09Z","timestamp":1569352449000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/cid\/article\/65\/7\/1222\/3852104\/Clinical-and-Molecular-Evidence-of-Atovaquone-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,24]]},"references-count":15,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,5,24]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/cix477","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,24]]}}}